SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells.

SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells.

The presence of human cytomegalovirus (HCMV) in glioblastoma (GBM) and improved outcomes of GBM patients receiving therapies targeting the virus have implicated HCMV in GBM progression. However, a unifying mechanism that accounts for the contribution of HCMV to the malignant phenotype of GBM remains...

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Bibliographic Details
Main Authors: Le Wen, Xian-Zhang Wang, Yong Qiu, Yue-Peng Zhou, Qing-Yang Zhang, Shuang Cheng, Jin-Yan Sun, Xing-Jun Jiang, Simon Rayner, William J Britt, Jian Chen, Fei Hu, Fang-Cheng Li, Min-Hua Luo, Han Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011316

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