Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics
Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial ag...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/6/708 |
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| author | Shreya Modi Gajendra Kumar Inwati Amel Gacem Shahabe Saquib Abullais Rajendra Prajapati Virendra Kumar Yadav Rabbani Syed Mohammed S. Alqahtani Krishna Kumar Yadav Saiful Islam Yongtae Ahn Byong-Hun Jeon |
| author_facet | Shreya Modi Gajendra Kumar Inwati Amel Gacem Shahabe Saquib Abullais Rajendra Prajapati Virendra Kumar Yadav Rabbani Syed Mohammed S. Alqahtani Krishna Kumar Yadav Saiful Islam Yongtae Ahn Byong-Hun Jeon |
| author_sort | Shreya Modi |
| collection | DOAJ |
| description | Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial agents, which are also known as “nanoantibiotics”. Nanomaterials have been shown to exert greater antibacterial effects on Gram-positive and Gram-negative bacteria across several studies. Antibacterial nanofilms for medical implants and restorative matters to prevent bacterial harm and antibacterial vaccinations to control bacterial infections are examples of nanoparticle applications in the biomedical sectors. The development of unique nanostructures, such as nanocrystals and nanostructured materials, is an exciting step in alternative efforts to manage microorganisms because these materials provide disrupted antibacterial effects, including better biocompatibility, as opposed to minor molecular antimicrobial systems, which have short-term functions and are poisonous. Although the mechanism of action of nanoparticles (NPs) is unknown, scientific suggestions include the oxidative-reductive phenomenon, reactive ionic metals, and reactive oxygen species (ROS). Many synchronized gene transformations in the same bacterial cell are essential for antibacterial resistance to emerge; thus, bacterial cells find it difficult to build resistance to nanoparticles. Therefore, nanomaterials are considered as advanced solution tools for the fields of medical science and allied health science. The current review emphasizes the importance of nanoparticles and various nanosized materials as antimicrobial agents based on their size, nature, etc. |
| first_indexed | 2024-03-10T00:36:55Z |
| format | Article |
| id | doaj.art-f5e74cdef56949abb889ea7e914c9cf6 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T00:36:55Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f5e74cdef56949abb889ea7e914c9cf62023-11-23T15:15:56ZengMDPI AGAntibiotics2079-63822022-05-0111670810.3390/antibiotics11060708Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of NanoantibioticsShreya Modi0Gajendra Kumar Inwati1Amel Gacem2Shahabe Saquib Abullais3Rajendra Prajapati4Virendra Kumar Yadav5Rabbani Syed6Mohammed S. Alqahtani7Krishna Kumar Yadav8Saiful Islam9Yongtae Ahn10Byong-Hun Jeon11Department of Microbiology, Shri Sarvajanik Science College, Mehsana 384001, IndiaDepartment of Chemistry, HVHP Institute of Post Graduate Studies and Research, Sarva Vishwavidyalaya, Kadi 382715, IndiaDepartment of Physics, Faculty of Sciences, University 20 Août 1955, Skikda 21000, AlgeriaDepartment of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Microbiology, Shri Sarvajanik Science College, Mehsana 384001, IndiaDepartment of Microbiology-Biosciences, School of Liberal Arts & Sciences, Mody University, Laxmangarh, Sikar, Rajasthan 332311, IndiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaFaculty of Science and Technology, Madhyanchal Professional University, Bhopal 462044, IndiaCivil Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Earth Resources & Environmental Engineering, Hanyang University, 222-Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaDepartment of Earth Resources & Environmental Engineering, Hanyang University, 222-Wangsimni-ro, Seongdong-gu, Seoul 04763, KoreaBacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial agents, which are also known as “nanoantibiotics”. Nanomaterials have been shown to exert greater antibacterial effects on Gram-positive and Gram-negative bacteria across several studies. Antibacterial nanofilms for medical implants and restorative matters to prevent bacterial harm and antibacterial vaccinations to control bacterial infections are examples of nanoparticle applications in the biomedical sectors. The development of unique nanostructures, such as nanocrystals and nanostructured materials, is an exciting step in alternative efforts to manage microorganisms because these materials provide disrupted antibacterial effects, including better biocompatibility, as opposed to minor molecular antimicrobial systems, which have short-term functions and are poisonous. Although the mechanism of action of nanoparticles (NPs) is unknown, scientific suggestions include the oxidative-reductive phenomenon, reactive ionic metals, and reactive oxygen species (ROS). Many synchronized gene transformations in the same bacterial cell are essential for antibacterial resistance to emerge; thus, bacterial cells find it difficult to build resistance to nanoparticles. Therefore, nanomaterials are considered as advanced solution tools for the fields of medical science and allied health science. The current review emphasizes the importance of nanoparticles and various nanosized materials as antimicrobial agents based on their size, nature, etc.https://www.mdpi.com/2079-6382/11/6/708nanomaterialsnanocompositesantibioticsantimicrobial agents |
| spellingShingle | Shreya Modi Gajendra Kumar Inwati Amel Gacem Shahabe Saquib Abullais Rajendra Prajapati Virendra Kumar Yadav Rabbani Syed Mohammed S. Alqahtani Krishna Kumar Yadav Saiful Islam Yongtae Ahn Byong-Hun Jeon Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics Antibiotics nanomaterials nanocomposites antibiotics antimicrobial agents |
| title | Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics |
| title_full | Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics |
| title_fullStr | Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics |
| title_full_unstemmed | Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics |
| title_short | Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics |
| title_sort | nanostructured antibiotics and their emerging medicinal applications an overview of nanoantibiotics |
| topic | nanomaterials nanocomposites antibiotics antimicrobial agents |
| url | https://www.mdpi.com/2079-6382/11/6/708 |
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