When liquid-liquid phase separation meets viral infections
Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown. Many biomolecules in the cytoplasm transition from the liquid phase to the agglutinated ph...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.985622/full |
| _version_ | 1811309217408090112 |
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| author | Wenqiang Wei Lu Bai Lu Bai Bing Yan Weiquan Meng Hongju Wang Jingbo Zhai Jingbo Zhai Fusheng Si Chunfu Zheng Chunfu Zheng |
| author_facet | Wenqiang Wei Lu Bai Lu Bai Bing Yan Weiquan Meng Hongju Wang Jingbo Zhai Jingbo Zhai Fusheng Si Chunfu Zheng Chunfu Zheng |
| author_sort | Wenqiang Wei |
| collection | DOAJ |
| description | Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown. Many biomolecules in the cytoplasm transition from the liquid phase to the agglutinated phase are known as liquid-liquid phase separation (LLPS). The biomolecular agglomerates’ physical properties enable them to function as dynamic compartments that respond to external pressures and stimuli. Scientists have gradually recognized the importance of phase separation during viral infections. LLPS provides a powerful new framework for understanding the viral life cycle from viral replication to evasion of host immune surveillance. As a result, this review focuses on the progress of LLPS research in viral infection and immune regulation to provide clues for antiviral therapeutic strategies. |
| first_indexed | 2024-04-13T09:37:16Z |
| format | Article |
| id | doaj.art-f5e9f883348d4f5f9ecd2f71d042d7fc |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T09:37:16Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f5e9f883348d4f5f9ecd2f71d042d7fc2022-12-22T02:52:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.985622985622When liquid-liquid phase separation meets viral infectionsWenqiang Wei0Lu Bai1Lu Bai2Bing Yan3Weiquan Meng4Hongju Wang5Jingbo Zhai6Jingbo Zhai7Fusheng Si8Chunfu Zheng9Chunfu Zheng10Kaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng, ChinaKaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaKaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng, ChinaKaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng, ChinaKaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng, ChinaMedical College, Inner Mongolia Minzu University, Tongliao, ChinaKey Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Tongliao, ChinaInstitute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Engineering Research Center of Breeding Pig, Shanghai Academy of Agricultural Sciences, Shanghai, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, CanadaEukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown. Many biomolecules in the cytoplasm transition from the liquid phase to the agglutinated phase are known as liquid-liquid phase separation (LLPS). The biomolecular agglomerates’ physical properties enable them to function as dynamic compartments that respond to external pressures and stimuli. Scientists have gradually recognized the importance of phase separation during viral infections. LLPS provides a powerful new framework for understanding the viral life cycle from viral replication to evasion of host immune surveillance. As a result, this review focuses on the progress of LLPS research in viral infection and immune regulation to provide clues for antiviral therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2022.985622/fullliquid-liquid phase separationmembraneless organelleinclusionviral infectionimmune regulation |
| spellingShingle | Wenqiang Wei Lu Bai Lu Bai Bing Yan Weiquan Meng Hongju Wang Jingbo Zhai Jingbo Zhai Fusheng Si Chunfu Zheng Chunfu Zheng When liquid-liquid phase separation meets viral infections Frontiers in Immunology liquid-liquid phase separation membraneless organelle inclusion viral infection immune regulation |
| title | When liquid-liquid phase separation meets viral infections |
| title_full | When liquid-liquid phase separation meets viral infections |
| title_fullStr | When liquid-liquid phase separation meets viral infections |
| title_full_unstemmed | When liquid-liquid phase separation meets viral infections |
| title_short | When liquid-liquid phase separation meets viral infections |
| title_sort | when liquid liquid phase separation meets viral infections |
| topic | liquid-liquid phase separation membraneless organelle inclusion viral infection immune regulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.985622/full |
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