Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats
Abstract Cytarabine is effectively used in the treatment of adult acute leukemia, but it has a dose-limiting side effect of fatal pulmonary oedema because it increases the vascular permeability of the alveolar capillaries. The aim of the present study was to conduct a radiological, biochemical and...
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Academia Brasileira de Ciências
2020-05-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100911&tlng=en |
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| author | ASLI O. BILGIN RENAD MAMMADOV BAHADIR SULEYMAN EDHEM UNVER FATIH OZCICEK MEHMET SOYTURK FERDA K. CIMEN NEZAHAT KURT HALIS SULEYMAN |
| author_facet | ASLI O. BILGIN RENAD MAMMADOV BAHADIR SULEYMAN EDHEM UNVER FATIH OZCICEK MEHMET SOYTURK FERDA K. CIMEN NEZAHAT KURT HALIS SULEYMAN |
| author_sort | ASLI O. BILGIN |
| collection | DOAJ |
| description | Abstract Cytarabine is effectively used in the treatment of adult acute leukemia, but it has a dose-limiting side effect of fatal pulmonary oedema because it increases the vascular permeability of the alveolar capillaries. The aim of the present study was to conduct a radiological, biochemical and histopathological investigation of the effect of rutin on cytarabine-associated pulmonary oedema in rats. Rats were treated with a combination of rutin+cytarabine by administering oral rutin at a dose of 50 mg/kg; other rat groups were orally administered the same volume of physiological saline. One hour after administration of rutin or saline, the rutin+cytarabine and cytarabine groups received an intraperitoneal injection of cytarabine (200 mg/kg). This administration procedure was repeated once a day for 14 days. Radiologically, 50% of the animals given cytarabine alone showed lung oedema, but the rutin+cytarabine group showed no oedema. The inclusion of rutin decreased the amounts of cytarabine-associated malondialdehyde, tumour necrosis factor-α, and nuclear factor-κB in the lung tissue. Rutin also inhibited the reduction of total glutathione by nitric oxide. These findings suggest that rutin may be a beneficial adjunct that can minimise the development of cytarabine-associated pulmonary oedema. |
| first_indexed | 2024-12-17T23:30:24Z |
| format | Article |
| id | doaj.art-f5ea0b9a22e94563a5476bf73b444f6b |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-17T23:30:24Z |
| publishDate | 2020-05-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-f5ea0b9a22e94563a5476bf73b444f6b2022-12-21T21:28:41ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902020-05-0192110.1590/0001-3765202020190261Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in RatsASLI O. BILGINhttps://orcid.org/0000-0001-9027-4299RENAD MAMMADOVhttps://orcid.org/0000-0002-5785-1960BAHADIR SULEYMANhttps://orcid.org/0000-0001-5795-3177EDHEM UNVERhttps://orcid.org/0000-0002-0322-8102FATIH OZCICEKhttps://orcid.org/0000-0003-3029-4524MEHMET SOYTURKhttps://orcid.org/0000-0002-9011-3660FERDA K. CIMENhttps://orcid.org/0000-0002-1844-0827NEZAHAT KURThttps://orcid.org/0000-0002-1685-5332HALIS SULEYMANhttps://orcid.org/0000-0002-9239-4099Abstract Cytarabine is effectively used in the treatment of adult acute leukemia, but it has a dose-limiting side effect of fatal pulmonary oedema because it increases the vascular permeability of the alveolar capillaries. The aim of the present study was to conduct a radiological, biochemical and histopathological investigation of the effect of rutin on cytarabine-associated pulmonary oedema in rats. Rats were treated with a combination of rutin+cytarabine by administering oral rutin at a dose of 50 mg/kg; other rat groups were orally administered the same volume of physiological saline. One hour after administration of rutin or saline, the rutin+cytarabine and cytarabine groups received an intraperitoneal injection of cytarabine (200 mg/kg). This administration procedure was repeated once a day for 14 days. Radiologically, 50% of the animals given cytarabine alone showed lung oedema, but the rutin+cytarabine group showed no oedema. The inclusion of rutin decreased the amounts of cytarabine-associated malondialdehyde, tumour necrosis factor-α, and nuclear factor-κB in the lung tissue. Rutin also inhibited the reduction of total glutathione by nitric oxide. These findings suggest that rutin may be a beneficial adjunct that can minimise the development of cytarabine-associated pulmonary oedema.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100911&tlng=enCytarabineoxidative stresspulmonary oedemarutin |
| spellingShingle | ASLI O. BILGIN RENAD MAMMADOV BAHADIR SULEYMAN EDHEM UNVER FATIH OZCICEK MEHMET SOYTURK FERDA K. CIMEN NEZAHAT KURT HALIS SULEYMAN Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats Anais da Academia Brasileira de Ciências Cytarabine oxidative stress pulmonary oedema rutin |
| title | Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats |
| title_full | Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats |
| title_fullStr | Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats |
| title_full_unstemmed | Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats |
| title_short | Effect of Rutin on Cytarabine-Associated Pulmonary Oedema and Oxidative Stress in Rats |
| title_sort | effect of rutin on cytarabine associated pulmonary oedema and oxidative stress in rats |
| topic | Cytarabine oxidative stress pulmonary oedema rutin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100911&tlng=en |
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