LncmiRHG-MIR100HG: A new budding star in cancer
MIR100HG, also known as lncRNA mir-100-let-7a-2-mir-125b-1 cluster host gene, is a new and critical regulator in cancers in recent years. MIR100HG is dysregulated in various cancers and plays an oncogenic or tumor-suppressive role, which participates in many tumor cell biology processes and cancer-r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.997532/full |
| _version_ | 1798001713645355008 |
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| author | Yingnan Wu Zhenzhen Wang Shan Yu Dongzhe Liu Litao Sun |
| author_facet | Yingnan Wu Zhenzhen Wang Shan Yu Dongzhe Liu Litao Sun |
| author_sort | Yingnan Wu |
| collection | DOAJ |
| description | MIR100HG, also known as lncRNA mir-100-let-7a-2-mir-125b-1 cluster host gene, is a new and critical regulator in cancers in recent years. MIR100HG is dysregulated in various cancers and plays an oncogenic or tumor-suppressive role, which participates in many tumor cell biology processes and cancer-related pathways. The errant expression of MIR100HG has inspired people to investigate the function of MIR100HG and its diagnostic and therapeutic potential in cancers. Many studies have indicated that dysregulated expression of MIR100HG is markedly correlated with poor prognosis and clinicopathological features. In this review, we will highlight the characteristics and introduce the role of MIR100HG in different cancers, and summarize the molecular mechanism, pathways, chemoresistance, and current research progress of MIR100HG in cancers. Furthermore, some open questions in this rapidly advancing field are proposed. These updates clarify our understanding of MIR100HG in cancers, which may pave the way for the application of MIR100HG-targeting approaches in future cancer diagnosis, prognosis, and therapy. |
| first_indexed | 2024-04-11T11:40:40Z |
| format | Article |
| id | doaj.art-f5ea50ba40064d7192ebd7a738165d03 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T11:40:40Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f5ea50ba40064d7192ebd7a738165d032022-12-22T04:25:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.997532997532LncmiRHG-MIR100HG: A new budding star in cancerYingnan Wu0Zhenzhen Wang1Shan Yu2Dongzhe Liu3Litao Sun4Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaCancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Pathology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University Health Science Center, Shenzhen, ChinaCancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaMIR100HG, also known as lncRNA mir-100-let-7a-2-mir-125b-1 cluster host gene, is a new and critical regulator in cancers in recent years. MIR100HG is dysregulated in various cancers and plays an oncogenic or tumor-suppressive role, which participates in many tumor cell biology processes and cancer-related pathways. The errant expression of MIR100HG has inspired people to investigate the function of MIR100HG and its diagnostic and therapeutic potential in cancers. Many studies have indicated that dysregulated expression of MIR100HG is markedly correlated with poor prognosis and clinicopathological features. In this review, we will highlight the characteristics and introduce the role of MIR100HG in different cancers, and summarize the molecular mechanism, pathways, chemoresistance, and current research progress of MIR100HG in cancers. Furthermore, some open questions in this rapidly advancing field are proposed. These updates clarify our understanding of MIR100HG in cancers, which may pave the way for the application of MIR100HG-targeting approaches in future cancer diagnosis, prognosis, and therapy.https://www.frontiersin.org/articles/10.3389/fonc.2022.997532/fulllncRNAlncmiRHGMIR100HGcancerbiomarkertherapeutic target |
| spellingShingle | Yingnan Wu Zhenzhen Wang Shan Yu Dongzhe Liu Litao Sun LncmiRHG-MIR100HG: A new budding star in cancer Frontiers in Oncology lncRNA lncmiRHG MIR100HG cancer biomarker therapeutic target |
| title | LncmiRHG-MIR100HG: A new budding star in cancer |
| title_full | LncmiRHG-MIR100HG: A new budding star in cancer |
| title_fullStr | LncmiRHG-MIR100HG: A new budding star in cancer |
| title_full_unstemmed | LncmiRHG-MIR100HG: A new budding star in cancer |
| title_short | LncmiRHG-MIR100HG: A new budding star in cancer |
| title_sort | lncmirhg mir100hg a new budding star in cancer |
| topic | lncRNA lncmiRHG MIR100HG cancer biomarker therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.997532/full |
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