AIDmut-Seq: a Three-Step Method for Detecting Protein-DNA Binding Specificity

AIDmut-Seq: a Three-Step Method for Detecting Protein-DNA Binding Specificity

ABSTRACT Transcriptional factors (TFs) and their regulons make up the gene regulatory networks. Here, we developed a method based on TF-directed activation-induced cytidine deaminase (AID) mutagenesis in combination with genome sequencing, called AIDmut-Seq, to detect TF targets on the genome. AIDmu...

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Bibliographic Details
Main Authors: Feixuan Li, Xiao-Yu Liu, Lei Ni, Fan Jin
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
activation induced cytidine deaminase
Pseudomonas aeruginosa
protein-DNA interactions
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03783-22

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