Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study
A few retrospective studies have suggested the risk of urolithiasis associated with the use of proton pump inhibitors (PPIs). The current research intended to estimate the risk of urolithiasis according to previous PPI use. A nested case-control study was conducted using the National Health Insuranc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/19/5693 |
| _version_ | 1797478659520462848 |
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| author | So Young Kim Dae Myoung Yoo Woo Jin Bang Hyo Geun Choi |
| author_facet | So Young Kim Dae Myoung Yoo Woo Jin Bang Hyo Geun Choi |
| author_sort | So Young Kim |
| collection | DOAJ |
| description | A few retrospective studies have suggested the risk of urolithiasis associated with the use of proton pump inhibitors (PPIs). The current research intended to estimate the risk of urolithiasis according to previous PPI use. A nested case-control study was conducted using the National Health Insurance Service-National Health Screening Cohort in Korea. A total of 28,962 patients with urolithiasis and 115,848 control participants were selected. The previous prescription history of PPI with days of PPI prescription was collected. To calculate the odds ratios (OR) of past, current, and days of PPI use for urolithiasis, logistic regression models were used. Subgroup analyses were conducted. The urolithiasis group demonstrated a higher rate of current PPI users than the control group (60.9% vs. 43.7%). The current PPI users indicated 2.49 times higher odds for urolithiasis than no PPI users (95% confidence intervals [CI] = 2.33–2.66). A longer duration of PPI use was associated with greater odds for urolithiasis (adjusted OR = 1.65 (95% CI = 1.54–1.77) < 1.97 (95% CI = 1.84–2.11) < 2.32 (95% CI = 2.14–2.49) for 1–19 days, 30–364 days, and 365 or more days of PPI prescription). All subgroup analyses described a consistently positive association of previous PPI use with urolithiasis. Prior PPI use was related to a higher risk of urolithiasis. The relationship between previous PPI use and urolithiasis demonstrated a dose-response association. |
| first_indexed | 2024-03-09T21:34:52Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:34:52Z |
| publishDate | 2022-09-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f5ede768cd934dcca5e805fe970069b82023-11-23T20:47:15ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011119569310.3390/jcm11195693Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control StudySo Young Kim0Dae Myoung Yoo1Woo Jin Bang2Hyo Geun Choi3Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, KoreaHallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, KoreaDepartment of Urology, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, KoreaHallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, KoreaA few retrospective studies have suggested the risk of urolithiasis associated with the use of proton pump inhibitors (PPIs). The current research intended to estimate the risk of urolithiasis according to previous PPI use. A nested case-control study was conducted using the National Health Insurance Service-National Health Screening Cohort in Korea. A total of 28,962 patients with urolithiasis and 115,848 control participants were selected. The previous prescription history of PPI with days of PPI prescription was collected. To calculate the odds ratios (OR) of past, current, and days of PPI use for urolithiasis, logistic regression models were used. Subgroup analyses were conducted. The urolithiasis group demonstrated a higher rate of current PPI users than the control group (60.9% vs. 43.7%). The current PPI users indicated 2.49 times higher odds for urolithiasis than no PPI users (95% confidence intervals [CI] = 2.33–2.66). A longer duration of PPI use was associated with greater odds for urolithiasis (adjusted OR = 1.65 (95% CI = 1.54–1.77) < 1.97 (95% CI = 1.84–2.11) < 2.32 (95% CI = 2.14–2.49) for 1–19 days, 30–364 days, and 365 or more days of PPI prescription). All subgroup analyses described a consistently positive association of previous PPI use with urolithiasis. Prior PPI use was related to a higher risk of urolithiasis. The relationship between previous PPI use and urolithiasis demonstrated a dose-response association.https://www.mdpi.com/2077-0383/11/19/5693urolithiasisproton pump inhibitorsrisk factorscase-control studiesepidemiology |
| spellingShingle | So Young Kim Dae Myoung Yoo Woo Jin Bang Hyo Geun Choi Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study Journal of Clinical Medicine urolithiasis proton pump inhibitors risk factors case-control studies epidemiology |
| title | Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study |
| title_full | Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study |
| title_fullStr | Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study |
| title_full_unstemmed | Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study |
| title_short | Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study |
| title_sort | association between urolithiasis and history proton pump inhibitor medication a nested case control study |
| topic | urolithiasis proton pump inhibitors risk factors case-control studies epidemiology |
| url | https://www.mdpi.com/2077-0383/11/19/5693 |
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