Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome
Psoriasis and metabolic syndrome (MetS), a common comorbidity of psoriasis, are associated with mild chronic systemic inflammation that increases oxidative stress and causes cell and tissue damage. At the cellular level, chromosomal and DNA damage has been documented, thus confirming their genotoxic...
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MDPI AG
2022-07-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/8/688 |
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| author | Drahomira Holmannova Pavel Borsky Ctirad Andrys Kvetoslava Hamakova Eva Cermakova Gabriela Poctova Zdenek Fiala Jindra Smejkalova Vladimir Blaha Lenka Borska |
| author_facet | Drahomira Holmannova Pavel Borsky Ctirad Andrys Kvetoslava Hamakova Eva Cermakova Gabriela Poctova Zdenek Fiala Jindra Smejkalova Vladimir Blaha Lenka Borska |
| author_sort | Drahomira Holmannova |
| collection | DOAJ |
| description | Psoriasis and metabolic syndrome (MetS), a common comorbidity of psoriasis, are associated with mild chronic systemic inflammation that increases oxidative stress and causes cell and tissue damage. At the cellular level, chromosomal and DNA damage has been documented, thus confirming their genotoxic effect. The main objective of our study was to show the genotoxic potential of chronic inflammation and determine whether the presence of both pathologies increases chromosomal damage compared to psoriasis alone and to evaluate whether there are correlations between selected parameters and chromosomal aberrations in patients with psoriasis and MetS psoriasis. Clinical examination (PASI score and MetS diagnostics according to National Cholesterol Education Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults; NCE/ATPIII criteria), biochemical analysis of blood samples (fasting glucose, total cholesterol, low density and high density lipoproteins; LDL, HDL, non-HDL, and triglycerides;TAG), DNA/RNA oxidative damage, and chromosomal aberration test were performed in 41 participants (20 patients with psoriasis without MetS and 21 with MetS and psoriasis). Our results showed that patients with psoriasis without metabolic syndrome (nonMetS) and psoriasis and MetS had a higher rate of chromosomal aberrations than the healthy population for which the limit of spontaneous, natural aberration was <2%. No significant differences in the aberration rate were found between the groups. However, a higher aberration rate (higher than 10%) and four numerical aberrations were documented only in the MetS group. We found no correlations between the number of chromosomal aberrations and the parameters tested except for the correlation between aberrations and HDL levels in nonMetS patients (rho 0.44; <i>p</i> < 0.02). Interestingly, in the MetS group, a higher number of chromosomal aberrations was documented in non-smokers compared to smokers. Data from our current study revealed an increased number of chromosomal aberrations in patients with psoriasis and MetS compared to the healthy population, especially in psoriasis with MetS, which could increase the genotoxic effect of inflammation and the risk of genomic instability, thus increasing the risk of carcinogenesis. |
| first_indexed | 2024-03-09T09:53:25Z |
| format | Article |
| id | doaj.art-f5ef68abb5464537a87069e751c003f0 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T09:53:25Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-f5ef68abb5464537a87069e751c003f02023-12-02T00:00:06ZengMDPI AGMetabolites2218-19892022-07-0112868810.3390/metabo12080688Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic SyndromeDrahomira Holmannova0Pavel Borsky1Ctirad Andrys2Kvetoslava Hamakova3Eva Cermakova4Gabriela Poctova5Zdenek Fiala6Jindra Smejkalova7Vladimir Blaha8Lenka Borska9Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech RepublicInstitute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech RepublicDepartment of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech RepublicClinic of Dermal and Venereal Diseases, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech RepublicDepartment of Medical Biophysics, Medical Faculty, Charles University, 500 03 Hradec Kralove, Czech RepublicInstitute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech RepublicInstitute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech RepublicInstitute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic3rd Department of Internal Medicine—Metabolic Care and Gerontology, Medical Faculty, Charles University, 500 03 Hradec Kralove, Czech RepublicInstitute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech RepublicPsoriasis and metabolic syndrome (MetS), a common comorbidity of psoriasis, are associated with mild chronic systemic inflammation that increases oxidative stress and causes cell and tissue damage. At the cellular level, chromosomal and DNA damage has been documented, thus confirming their genotoxic effect. The main objective of our study was to show the genotoxic potential of chronic inflammation and determine whether the presence of both pathologies increases chromosomal damage compared to psoriasis alone and to evaluate whether there are correlations between selected parameters and chromosomal aberrations in patients with psoriasis and MetS psoriasis. Clinical examination (PASI score and MetS diagnostics according to National Cholesterol Education Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults; NCE/ATPIII criteria), biochemical analysis of blood samples (fasting glucose, total cholesterol, low density and high density lipoproteins; LDL, HDL, non-HDL, and triglycerides;TAG), DNA/RNA oxidative damage, and chromosomal aberration test were performed in 41 participants (20 patients with psoriasis without MetS and 21 with MetS and psoriasis). Our results showed that patients with psoriasis without metabolic syndrome (nonMetS) and psoriasis and MetS had a higher rate of chromosomal aberrations than the healthy population for which the limit of spontaneous, natural aberration was <2%. No significant differences in the aberration rate were found between the groups. However, a higher aberration rate (higher than 10%) and four numerical aberrations were documented only in the MetS group. We found no correlations between the number of chromosomal aberrations and the parameters tested except for the correlation between aberrations and HDL levels in nonMetS patients (rho 0.44; <i>p</i> < 0.02). Interestingly, in the MetS group, a higher number of chromosomal aberrations was documented in non-smokers compared to smokers. Data from our current study revealed an increased number of chromosomal aberrations in patients with psoriasis and MetS compared to the healthy population, especially in psoriasis with MetS, which could increase the genotoxic effect of inflammation and the risk of genomic instability, thus increasing the risk of carcinogenesis.https://www.mdpi.com/2218-1989/12/8/688chromosomal aberrationpsoriasismetabolic syndrome |
| spellingShingle | Drahomira Holmannova Pavel Borsky Ctirad Andrys Kvetoslava Hamakova Eva Cermakova Gabriela Poctova Zdenek Fiala Jindra Smejkalova Vladimir Blaha Lenka Borska Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome Metabolites chromosomal aberration psoriasis metabolic syndrome |
| title | Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome |
| title_full | Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome |
| title_fullStr | Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome |
| title_full_unstemmed | Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome |
| title_short | Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with and without Metabolic Syndrome |
| title_sort | chromosomal aberrations and oxidative stress in psoriatic patients with and without metabolic syndrome |
| topic | chromosomal aberration psoriasis metabolic syndrome |
| url | https://www.mdpi.com/2218-1989/12/8/688 |
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