E3 Ubiquitin Ligase <i>TRIP12</i> Controls Exit from Mitosis via Positive Regulation of <i>MCL-1</i> in Response to Taxol

E3 Ubiquitin Ligase <i>TRIP12</i> Controls Exit from Mitosis via Positive Regulation of <i>MCL-1</i> in Response to Taxol

Chemotherapy resistance is a major hurdle in cancer treatment. Taxol-based chemotherapy is widely used in the treatment of cancers including breast, ovarian, and pancreatic cancer. Loss of function of the tumor suppressor F-box WD-40 domain containing 7 (<i>FBW7</i>) mutations leads to t...

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Bibliographic Details
Main Authors: Kripa S. Keyan, Rania Alanany, Amira Kohil, Omar M. Khan
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
<i>FBW7</i>
<i>MCL-1</i>
chemotherapy
Taxol
proteasomal degradation
mitotic arrest
Online Access:https://www.mdpi.com/2072-6694/15/2/505

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