T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin
Background: T-cadherin is an atypical glycosylphosphatidylinositol-anchored member of the cadherin superfamily of adhesion molecules. The role of T-cadherin in biology of the skin is poorly understood. Expression of T-cadherin in basal keratinocytes and dermal blood vessels of the healthy epidermis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-10-01
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| Series: | Dermatopathology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/451024 |
| _version_ | 1818599269994594304 |
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| author | Stanislaw Buechner Paul Erne Therese J. Resink |
| author_facet | Stanislaw Buechner Paul Erne Therese J. Resink |
| author_sort | Stanislaw Buechner |
| collection | DOAJ |
| description | Background: T-cadherin is an atypical glycosylphosphatidylinositol-anchored member of the cadherin superfamily of adhesion molecules. The role of T-cadherin in biology of the skin is poorly understood. Expression of T-cadherin in basal keratinocytes and dermal blood vessels of the healthy epidermis has been demonstrated, but studies on expression in skin appendages are rare. Methods: We conducted an immunohistochemical analysis of T-cadherin expression in the epidermis and adnexal structures of normal skin. Results: T-cadherin expression is restricted to basal keratinocytes of the epidermis. The basal cell layer of sebaceous glands was T-cadherin positive, whereas sebocytes were negative. Within apocrine glands, only myoepithelial cells were T-cadherin positive. In contrast, both the secretory coils and excretory ducts of eccrine glands were T-cadherin positive. In terminal hair follicles, the outer root sheath layers strongly expressed T-cadherin throughout different regions of the follicle, with the strongest immunoreactivity at the bulge and suprabulbar regions. T-cadherin and CK15 stem cell marker similarly localized within the bulge and suprabulbar region. T-cadherin and CD34 stem cell marker similarly localized at the suprabulbar level. Conclusion: The specific patterns of T-cadherin expression in the epidermis and adnexal structures suggest an important guardian role in skin homeostasis. |
| first_indexed | 2024-12-16T12:16:55Z |
| format | Article |
| id | doaj.art-f5f0f509186b44a69a30910bf3a6bc18 |
| institution | Directory Open Access Journal |
| issn | 2296-3529 |
| language | English |
| last_indexed | 2024-12-16T12:16:55Z |
| publishDate | 2016-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dermatopathology |
| spelling | doaj.art-f5f0f509186b44a69a30910bf3a6bc182022-12-21T22:32:04ZengMDPI AGDermatopathology2296-35292016-10-0134687810.1159/000451024451024T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal SkinStanislaw BuechnerPaul ErneTherese J. ResinkBackground: T-cadherin is an atypical glycosylphosphatidylinositol-anchored member of the cadherin superfamily of adhesion molecules. The role of T-cadherin in biology of the skin is poorly understood. Expression of T-cadherin in basal keratinocytes and dermal blood vessels of the healthy epidermis has been demonstrated, but studies on expression in skin appendages are rare. Methods: We conducted an immunohistochemical analysis of T-cadherin expression in the epidermis and adnexal structures of normal skin. Results: T-cadherin expression is restricted to basal keratinocytes of the epidermis. The basal cell layer of sebaceous glands was T-cadherin positive, whereas sebocytes were negative. Within apocrine glands, only myoepithelial cells were T-cadherin positive. In contrast, both the secretory coils and excretory ducts of eccrine glands were T-cadherin positive. In terminal hair follicles, the outer root sheath layers strongly expressed T-cadherin throughout different regions of the follicle, with the strongest immunoreactivity at the bulge and suprabulbar regions. T-cadherin and CK15 stem cell marker similarly localized within the bulge and suprabulbar region. T-cadherin and CD34 stem cell marker similarly localized at the suprabulbar level. Conclusion: The specific patterns of T-cadherin expression in the epidermis and adnexal structures suggest an important guardian role in skin homeostasis.http://www.karger.com/Article/FullText/451024T-cadherinImmunohistochemistryEpidermisSkin appendages |
| spellingShingle | Stanislaw Buechner Paul Erne Therese J. Resink T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin Dermatopathology T-cadherin Immunohistochemistry Epidermis Skin appendages |
| title | T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin |
| title_full | T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin |
| title_fullStr | T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin |
| title_full_unstemmed | T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin |
| title_short | T-Cadherin Expression in the Epidermis and Adnexal Structures of Normal Skin |
| title_sort | t cadherin expression in the epidermis and adnexal structures of normal skin |
| topic | T-cadherin Immunohistochemistry Epidermis Skin appendages |
| url | http://www.karger.com/Article/FullText/451024 |
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