Significance of Metformin Use in Diabetic Kidney Disease
Metformin is a glucose-lowering agent that is used as a first-line therapy for type 2 diabetes (T2D). Based on its various pharmacologic actions, the renoprotective effects of metformin have been extensively studied. A series of experimental studies demonstrated that metformin attenuates diabetic ki...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/12/4239 |
| _version_ | 1797565400947359744 |
|---|---|
| author | Daiji Kawanami Yuichi Takashi Makito Tanabe |
| author_facet | Daiji Kawanami Yuichi Takashi Makito Tanabe |
| author_sort | Daiji Kawanami |
| collection | DOAJ |
| description | Metformin is a glucose-lowering agent that is used as a first-line therapy for type 2 diabetes (T2D). Based on its various pharmacologic actions, the renoprotective effects of metformin have been extensively studied. A series of experimental studies demonstrated that metformin attenuates diabetic kidney disease (DKD) by suppressing renal inflammation, oxidative stress and fibrosis. In clinical studies, metformin use has been shown to be associated with reduced rates of mortality, cardiovascular disease and progression to end-stage renal disease (ESRD) in T2D patients with chronic kidney disease (CKD). However, metformin should be administered with caution to patients with CKD because it may increase the risk of lactic acidosis. In this review article, we summarize our current understanding of the safety and efficacy of metformin for DKD. |
| first_indexed | 2024-03-10T19:11:38Z |
| format | Article |
| id | doaj.art-f5f1a53bf948455589c7ec98c8c77167 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:11:38Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f5f1a53bf948455589c7ec98c8c771672023-11-20T03:47:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012112423910.3390/ijms21124239Significance of Metformin Use in Diabetic Kidney DiseaseDaiji Kawanami0Yuichi Takashi1Makito Tanabe2Department of Endocrinology and Diabetes Mellitus, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanMetformin is a glucose-lowering agent that is used as a first-line therapy for type 2 diabetes (T2D). Based on its various pharmacologic actions, the renoprotective effects of metformin have been extensively studied. A series of experimental studies demonstrated that metformin attenuates diabetic kidney disease (DKD) by suppressing renal inflammation, oxidative stress and fibrosis. In clinical studies, metformin use has been shown to be associated with reduced rates of mortality, cardiovascular disease and progression to end-stage renal disease (ESRD) in T2D patients with chronic kidney disease (CKD). However, metformin should be administered with caution to patients with CKD because it may increase the risk of lactic acidosis. In this review article, we summarize our current understanding of the safety and efficacy of metformin for DKD.https://www.mdpi.com/1422-0067/21/12/4239metformindiabetic nephropathydiabetic kidney diseaseCKDcardiovascular disease |
| spellingShingle | Daiji Kawanami Yuichi Takashi Makito Tanabe Significance of Metformin Use in Diabetic Kidney Disease International Journal of Molecular Sciences metformin diabetic nephropathy diabetic kidney disease CKD cardiovascular disease |
| title | Significance of Metformin Use in Diabetic Kidney Disease |
| title_full | Significance of Metformin Use in Diabetic Kidney Disease |
| title_fullStr | Significance of Metformin Use in Diabetic Kidney Disease |
| title_full_unstemmed | Significance of Metformin Use in Diabetic Kidney Disease |
| title_short | Significance of Metformin Use in Diabetic Kidney Disease |
| title_sort | significance of metformin use in diabetic kidney disease |
| topic | metformin diabetic nephropathy diabetic kidney disease CKD cardiovascular disease |
| url | https://www.mdpi.com/1422-0067/21/12/4239 |
| work_keys_str_mv | AT daijikawanami significanceofmetforminuseindiabetickidneydisease AT yuichitakashi significanceofmetforminuseindiabetickidneydisease AT makitotanabe significanceofmetforminuseindiabetickidneydisease |