Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling
Chromatin remodelling enzymes (remodellers) regulate DNA accessibility of eukaryotic genomes, which rely in large part on an ability to reposition nucleosomes. Here the authors use three-colour single-molecule FRET to simultaneously monitor remodeller-induced DNA movements on both sides of the nucle...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09657-1 |
| _version_ | 1818842163413254144 |
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| author | Anton Sabantsev Robert F. Levendosky Xiaowei Zhuang Gregory D. Bowman Sebastian Deindl |
| author_facet | Anton Sabantsev Robert F. Levendosky Xiaowei Zhuang Gregory D. Bowman Sebastian Deindl |
| author_sort | Anton Sabantsev |
| collection | DOAJ |
| description | Chromatin remodelling enzymes (remodellers) regulate DNA accessibility of eukaryotic genomes, which rely in large part on an ability to reposition nucleosomes. Here the authors use three-colour single-molecule FRET to simultaneously monitor remodeller-induced DNA movements on both sides of the nucleosome in real-time. |
| first_indexed | 2024-12-19T04:37:36Z |
| format | Article |
| id | doaj.art-f5f376ca46c6431b91508a7dcbf9f536 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:37:36Z |
| publishDate | 2019-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f5f376ca46c6431b91508a7dcbf9f5362022-12-21T20:35:43ZengNature PortfolioNature Communications2041-17232019-04-0110111210.1038/s41467-019-09657-1Direct observation of coordinated DNA movements on the nucleosome during chromatin remodellingAnton Sabantsev0Robert F. Levendosky1Xiaowei Zhuang2Gregory D. Bowman3Sebastian Deindl4Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala UniversityT.C. Jenkins Department of Biophysics, Johns Hopkins UniversityHoward Hughes Medical Institute, Harvard UniversityT.C. Jenkins Department of Biophysics, Johns Hopkins UniversityDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala UniversityChromatin remodelling enzymes (remodellers) regulate DNA accessibility of eukaryotic genomes, which rely in large part on an ability to reposition nucleosomes. Here the authors use three-colour single-molecule FRET to simultaneously monitor remodeller-induced DNA movements on both sides of the nucleosome in real-time.https://doi.org/10.1038/s41467-019-09657-1 |
| spellingShingle | Anton Sabantsev Robert F. Levendosky Xiaowei Zhuang Gregory D. Bowman Sebastian Deindl Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling Nature Communications |
| title | Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling |
| title_full | Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling |
| title_fullStr | Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling |
| title_full_unstemmed | Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling |
| title_short | Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling |
| title_sort | direct observation of coordinated dna movements on the nucleosome during chromatin remodelling |
| url | https://doi.org/10.1038/s41467-019-09657-1 |
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