Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, Angola
Introduction: There are several causes that lead to malnutrition in acquired immunodeficiency syndrome. However, cellular immunosuppression with a decrease in CD4 + T lymphocytes represents the main conditioning factor. Objective: to relate antiretroviral changes on body weight and CD4 + T lymphocy...
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| Format: | Article |
| Language: | Spanish |
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ECIMED
2017-11-01
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| Series: | Revista de Ciencias Médicas de Pinar del Río |
| Subjects: | |
| Online Access: | http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3216 |
| _version_ | 1819061321310666752 |
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| author | Elisa Maritza Linares Guerra Nurmys Cristina Martínez Zamora Mauro de Jesús Samanjata José Agostinho da Silva Mendes María Amparo León Sánchez |
| author_facet | Elisa Maritza Linares Guerra Nurmys Cristina Martínez Zamora Mauro de Jesús Samanjata José Agostinho da Silva Mendes María Amparo León Sánchez |
| author_sort | Elisa Maritza Linares Guerra |
| collection | DOAJ |
| description | Introduction: There are several causes that lead to malnutrition in acquired immunodeficiency syndrome. However, cellular immunosuppression with a decrease in CD4 + T lymphocytes represents the main conditioning factor.
Objective: to relate antiretroviral changes on body weight and CD4 + T lymphocyte count in HIV / AIDS patients from the province of Benguela, Angola.
Method: a case-control study was conducted in 190 adults with HIV / AIDS treated at Benguela Provincial External Bank Hospital, with three months or more of patients treated with antiretroviral (women: 70.5%, mean age: 36 , 1 year,> 35 years with HIV + diagnosis: 46.8%, 3-18 months with antiretroviral: 48.9%). The absolute CD4 + T cell count and weight were measured before starting the therapy (initial value) and at the last visit (final value). The relative changes or gradients (final value - initial value / initial value) of both variables were calculated. A comparison of means for related and independent samples was performed by non-parametric tests. The association between weight gradients and CD4 counts was estimated using the Odds-Ratio and its confidence interval; 95% of confidence was considered for all statistical tests.
Results: the mean of weight and absolute CD4 + T cell counts increased significantly after the retroviral therapy (p <0.001). A significant association was found between the weight gradient and the CD4 gradient (OR = 3.61; CI (95%): 1.61-8.11).
Conclusion: the relative changes in body weight in individuals suffering from HIV / AIDS as a result of antiretroviral therapy could be used to follow up and monitor the immune response to antiretroviral in countries with shortage of economic resources. |
| first_indexed | 2024-12-21T14:41:02Z |
| format | Article |
| id | doaj.art-f5fbe093b4ec435b918876d3cfa7aea0 |
| institution | Directory Open Access Journal |
| issn | 1561-3194 |
| language | Spanish |
| last_indexed | 2024-12-21T14:41:02Z |
| publishDate | 2017-11-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista de Ciencias Médicas de Pinar del Río |
| spelling | doaj.art-f5fbe093b4ec435b918876d3cfa7aea02022-12-21T19:00:12ZspaECIMEDRevista de Ciencias Médicas de Pinar del Río1561-31942017-11-012167707791534Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, AngolaElisa Maritza Linares Guerra0Nurmys Cristina Martínez Zamora1Mauro de Jesús Samanjata2José Agostinho da Silva Mendes3María Amparo León Sánchez4. Universidad de Pinar del Río, Cuba.Universidad de Ciencias Médicas de Villa Clara. Cuba.Hospital General de Benguela, Angola.Hospital General de Benguela, Angola.Universidad de Pinar del Río, Cuba.Introduction: There are several causes that lead to malnutrition in acquired immunodeficiency syndrome. However, cellular immunosuppression with a decrease in CD4 + T lymphocytes represents the main conditioning factor. Objective: to relate antiretroviral changes on body weight and CD4 + T lymphocyte count in HIV / AIDS patients from the province of Benguela, Angola. Method: a case-control study was conducted in 190 adults with HIV / AIDS treated at Benguela Provincial External Bank Hospital, with three months or more of patients treated with antiretroviral (women: 70.5%, mean age: 36 , 1 year,> 35 years with HIV + diagnosis: 46.8%, 3-18 months with antiretroviral: 48.9%). The absolute CD4 + T cell count and weight were measured before starting the therapy (initial value) and at the last visit (final value). The relative changes or gradients (final value - initial value / initial value) of both variables were calculated. A comparison of means for related and independent samples was performed by non-parametric tests. The association between weight gradients and CD4 counts was estimated using the Odds-Ratio and its confidence interval; 95% of confidence was considered for all statistical tests. Results: the mean of weight and absolute CD4 + T cell counts increased significantly after the retroviral therapy (p <0.001). A significant association was found between the weight gradient and the CD4 gradient (OR = 3.61; CI (95%): 1.61-8.11). Conclusion: the relative changes in body weight in individuals suffering from HIV / AIDS as a result of antiretroviral therapy could be used to follow up and monitor the immune response to antiretroviral in countries with shortage of economic resources.http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3216VIHSÍNDROME DE INMUNODEFICIENCIA ADQUIRIDATERAPIA ANTIRRETROVIRAL ALTAMENTE ACTIVAPESO CORPORAL. |
| spellingShingle | Elisa Maritza Linares Guerra Nurmys Cristina Martínez Zamora Mauro de Jesús Samanjata José Agostinho da Silva Mendes María Amparo León Sánchez Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, Angola Revista de Ciencias Médicas de Pinar del Río VIH SÍNDROME DE INMUNODEFICIENCIA ADQUIRIDA TERAPIA ANTIRRETROVIRAL ALTAMENTE ACTIVA PESO CORPORAL. |
| title | Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, Angola |
| title_full | Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, Angola |
| title_fullStr | Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, Angola |
| title_full_unstemmed | Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, Angola |
| title_short | Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, Angola |
| title_sort | changes in weight and cd4 t cells in hiv aids individuals with antiretroviral angola |
| topic | VIH SÍNDROME DE INMUNODEFICIENCIA ADQUIRIDA TERAPIA ANTIRRETROVIRAL ALTAMENTE ACTIVA PESO CORPORAL. |
| url | http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3216 |
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