The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum
One in five patients with Inflammatory Bowel Disease (IBD) suffers from anemia, most frequently caused by iron deficiency. Anemia and iron deficiency are associated with worse disease outcomes, reduced quality of life, decreased economic participation, and increased healthcare costs. International g...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231723003518 |
| _version_ | 1797405477209899008 |
|---|---|
| author | R. Loveikyte A.R. Bourgonje H. van Goor G. Dijkstra A.E. van der Meulen – de Jong |
| author_facet | R. Loveikyte A.R. Bourgonje H. van Goor G. Dijkstra A.E. van der Meulen – de Jong |
| author_sort | R. Loveikyte |
| collection | DOAJ |
| description | One in five patients with Inflammatory Bowel Disease (IBD) suffers from anemia, most frequently caused by iron deficiency. Anemia and iron deficiency are associated with worse disease outcomes, reduced quality of life, decreased economic participation, and increased healthcare costs. International guidelines and consensus-based recommendations have emphasized the importance of treating anemia and iron deficiency. In this review, we draw attention to the rarely discussed effects of iron deficiency and iron therapy on the redox status, the intestinal microbiota, and the potential interplay between them, focusing on the clinical implications for patients with IBD. Current data are scarce, inconsistent, and do not provide definitive answers. Nevertheless, it is imperative to rule out infections and discern iron deficiency anemia from other types of anemia to prevent untargeted oral or intravenous iron supplementation and potential side effects, including oxidative stress. Further research is necessary to establish the clinical significance of changes in the redox status and the intestinal microbiota following iron supplementation. |
| first_indexed | 2024-03-09T03:11:29Z |
| format | Article |
| id | doaj.art-f5fdc152854b4dfeaba8c61ed067f492 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-03-09T03:11:29Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-f5fdc152854b4dfeaba8c61ed067f4922023-12-04T05:21:48ZengElsevierRedox Biology2213-23172023-12-0168102950The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrumR. Loveikyte0A.R. Bourgonje1H. van Goor2G. Dijkstra3A.E. van der Meulen – de Jong4Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Corresponding author. Department of Gastroenterology and Hepatology, Leiden University Medical Center, Stafsecretariaat MDL (t.a.v. Drs. R. Loveikyte), Albinusdreef 2 – C4P, 2300RC, Leiden, the Netherlands.Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the NetherlandsOne in five patients with Inflammatory Bowel Disease (IBD) suffers from anemia, most frequently caused by iron deficiency. Anemia and iron deficiency are associated with worse disease outcomes, reduced quality of life, decreased economic participation, and increased healthcare costs. International guidelines and consensus-based recommendations have emphasized the importance of treating anemia and iron deficiency. In this review, we draw attention to the rarely discussed effects of iron deficiency and iron therapy on the redox status, the intestinal microbiota, and the potential interplay between them, focusing on the clinical implications for patients with IBD. Current data are scarce, inconsistent, and do not provide definitive answers. Nevertheless, it is imperative to rule out infections and discern iron deficiency anemia from other types of anemia to prevent untargeted oral or intravenous iron supplementation and potential side effects, including oxidative stress. Further research is necessary to establish the clinical significance of changes in the redox status and the intestinal microbiota following iron supplementation.http://www.sciencedirect.com/science/article/pii/S2213231723003518Iron deficiencyOxidative stressIntestinal microbiotaIron supplementationInflammatory bowel disease |
| spellingShingle | R. Loveikyte A.R. Bourgonje H. van Goor G. Dijkstra A.E. van der Meulen – de Jong The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum Redox Biology Iron deficiency Oxidative stress Intestinal microbiota Iron supplementation Inflammatory bowel disease |
| title | The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum |
| title_full | The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum |
| title_fullStr | The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum |
| title_full_unstemmed | The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum |
| title_short | The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum |
| title_sort | effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases a review on the conundrum |
| topic | Iron deficiency Oxidative stress Intestinal microbiota Iron supplementation Inflammatory bowel disease |
| url | http://www.sciencedirect.com/science/article/pii/S2213231723003518 |
| work_keys_str_mv | AT rloveikyte theeffectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT arbourgonje theeffectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT hvangoor theeffectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT gdijkstra theeffectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT aevandermeulendejong theeffectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT rloveikyte effectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT arbourgonje effectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT hvangoor effectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT gdijkstra effectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum AT aevandermeulendejong effectofirontherapyonoxidativestressandintestinalmicrobiotaininflammatoryboweldiseasesareviewontheconundrum |