Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds
Due to the rapid mutation of pathogenic microorganisms, drug-resistant superbugs have evolved. Antimicrobial-resistant germs may share their resistance genes with other germs, making them untreatable. The search for more combative antibiotic compounds has led researchers to explore metal-based strat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/2/158 |
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| author | Israel Rodríguez Lauren Fernández-Vega Andrea N. Maser-Figueroa Branlee Sang Patricia González-Pagán Arthur D. Tinoco |
| author_facet | Israel Rodríguez Lauren Fernández-Vega Andrea N. Maser-Figueroa Branlee Sang Patricia González-Pagán Arthur D. Tinoco |
| author_sort | Israel Rodríguez |
| collection | DOAJ |
| description | Due to the rapid mutation of pathogenic microorganisms, drug-resistant superbugs have evolved. Antimicrobial-resistant germs may share their resistance genes with other germs, making them untreatable. The search for more combative antibiotic compounds has led researchers to explore metal-based strategies centered on perturbing the bioavailability of essential metals in microbes and examining the therapeutic potential of metal complexes. Given the limited knowledge on the application of titanium(IV), in this work, eight Ti(IV) complexes and some of their corresponding ligands were screened by the Community for Open Antimicrobial Drug Discovery for antimicrobial activity. The compounds were selected for evaluation because of their low cytotoxic/antiproliferative behavior against a human non-cancer cell line. At pH 7.4, these compounds vary in terms of their solution stability and ligand exchange lability; therefore, an assessment of their solution behavior provides some insight regarding the importance of the identity of the metal compound to the antimicrobial therapeutic potential. Only one compound, Ti(deferasirox)<sub>2</sub>, exhibited promising inhibitory activity against the Gram-positive bacteria methicillin-resistant <i>Staphylococcus aureus</i> and minimal toxicity against human cells. The ability of this compound to undergo transmetalation with labile Fe(III) sources and, as a consequence, inhibit Fe bioavailability and ribonucleotide reductase is evaluated as a possible mechanism for its antibiotic effect. |
| first_indexed | 2024-03-09T22:47:57Z |
| format | Article |
| id | doaj.art-f5fddf23db764ce6b5928cd22859f86a |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T22:47:57Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f5fddf23db764ce6b5928cd22859f86a2023-11-23T18:27:24ZengMDPI AGAntibiotics2079-63822022-01-0111215810.3390/antibiotics11020158Exploring Titanium(IV) Complexes as Potential Antimicrobial CompoundsIsrael Rodríguez0Lauren Fernández-Vega1Andrea N. Maser-Figueroa2Branlee Sang3Patricia González-Pagán4Arthur D. Tinoco5Department of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan 00925, Puerto RicoDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan 00925, Puerto RicoDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan 00925, Puerto RicoDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan 00925, Puerto RicoDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan 00925, Puerto RicoDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan 00925, Puerto RicoDue to the rapid mutation of pathogenic microorganisms, drug-resistant superbugs have evolved. Antimicrobial-resistant germs may share their resistance genes with other germs, making them untreatable. The search for more combative antibiotic compounds has led researchers to explore metal-based strategies centered on perturbing the bioavailability of essential metals in microbes and examining the therapeutic potential of metal complexes. Given the limited knowledge on the application of titanium(IV), in this work, eight Ti(IV) complexes and some of their corresponding ligands were screened by the Community for Open Antimicrobial Drug Discovery for antimicrobial activity. The compounds were selected for evaluation because of their low cytotoxic/antiproliferative behavior against a human non-cancer cell line. At pH 7.4, these compounds vary in terms of their solution stability and ligand exchange lability; therefore, an assessment of their solution behavior provides some insight regarding the importance of the identity of the metal compound to the antimicrobial therapeutic potential. Only one compound, Ti(deferasirox)<sub>2</sub>, exhibited promising inhibitory activity against the Gram-positive bacteria methicillin-resistant <i>Staphylococcus aureus</i> and minimal toxicity against human cells. The ability of this compound to undergo transmetalation with labile Fe(III) sources and, as a consequence, inhibit Fe bioavailability and ribonucleotide reductase is evaluated as a possible mechanism for its antibiotic effect.https://www.mdpi.com/2079-6382/11/2/158transmetalationtitanium(IV) antimicrobial compoundsiron chelation |
| spellingShingle | Israel Rodríguez Lauren Fernández-Vega Andrea N. Maser-Figueroa Branlee Sang Patricia González-Pagán Arthur D. Tinoco Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds Antibiotics transmetalation titanium(IV) antimicrobial compounds iron chelation |
| title | Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds |
| title_full | Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds |
| title_fullStr | Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds |
| title_full_unstemmed | Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds |
| title_short | Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds |
| title_sort | exploring titanium iv complexes as potential antimicrobial compounds |
| topic | transmetalation titanium(IV) antimicrobial compounds iron chelation |
| url | https://www.mdpi.com/2079-6382/11/2/158 |
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