Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018
Abstract Background Influenza viruses are a continuous threat to avian and mammalian species, causing epidemics and pandemics. After the circulation of H5N1 in 2006, 2015, and 2016 in Iraq, an H5N8 influenza virus emerged in domestic geese in Sulaymaniyah Province, Iraq. This study analyzed the gene...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-03-01
|
| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12917-021-02831-y |
| _version_ | 1818862616681906176 |
|---|---|
| author | Nahla Muhammad Saeed Peshnyar Muhammad Atta Rashid Hiewa Othman Dyary |
| author_facet | Nahla Muhammad Saeed Peshnyar Muhammad Atta Rashid Hiewa Othman Dyary |
| author_sort | Nahla Muhammad Saeed |
| collection | DOAJ |
| description | Abstract Background Influenza viruses are a continuous threat to avian and mammalian species, causing epidemics and pandemics. After the circulation of H5N1 in 2006, 2015, and 2016 in Iraq, an H5N8 influenza virus emerged in domestic geese in Sulaymaniyah Province, Iraq. This study analyzed the genetic characteristics of the Iraqi H5N8 viruses. Results An HPAI virus subtype H5N8 was identified from domestic backyard geese in the Kurdistan Region, north Iraq. Phylogenic analyses of the hemagglutinin (HA) and neuraminidase (NA) genes indicated that Iraq H5N8 viruses belonged to clade 2.3.4.4 group B and clustered with isolates from Iran, Israel, and Belgium. Genetic analysis of the HA gene indicated molecular markers for avian-type receptors. Characterization of the NA gene showed that the virus had sensitive molecular markers for antiviral drugs. Conclusions This is the first study ever on H5N8 in Iraq, and it is crucial to understand the epidemiology of the viruses in Iraq and the Middle East. The results suggest a possible role of migratory birds in the introduction of HPAI subtype H5N8 into Iraq. |
| first_indexed | 2024-12-19T10:02:42Z |
| format | Article |
| id | doaj.art-f5ff6b08546b480ebde00159779e5eb3 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-19T10:02:42Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-f5ff6b08546b480ebde00159779e5eb32022-12-21T20:26:36ZengBMCBMC Veterinary Research1746-61482021-03-011711710.1186/s12917-021-02831-yGenetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018Nahla Muhammad Saeed0Peshnyar Muhammad Atta Rashid1Hiewa Othman Dyary2College of Veterinary Medicine, University of SulaimaniMolecular Diagnostic Laboratory, Directorate of Veterinary ServicesCollege of Veterinary Medicine, University of SulaimaniAbstract Background Influenza viruses are a continuous threat to avian and mammalian species, causing epidemics and pandemics. After the circulation of H5N1 in 2006, 2015, and 2016 in Iraq, an H5N8 influenza virus emerged in domestic geese in Sulaymaniyah Province, Iraq. This study analyzed the genetic characteristics of the Iraqi H5N8 viruses. Results An HPAI virus subtype H5N8 was identified from domestic backyard geese in the Kurdistan Region, north Iraq. Phylogenic analyses of the hemagglutinin (HA) and neuraminidase (NA) genes indicated that Iraq H5N8 viruses belonged to clade 2.3.4.4 group B and clustered with isolates from Iran, Israel, and Belgium. Genetic analysis of the HA gene indicated molecular markers for avian-type receptors. Characterization of the NA gene showed that the virus had sensitive molecular markers for antiviral drugs. Conclusions This is the first study ever on H5N8 in Iraq, and it is crucial to understand the epidemiology of the viruses in Iraq and the Middle East. The results suggest a possible role of migratory birds in the introduction of HPAI subtype H5N8 into Iraq.https://doi.org/10.1186/s12917-021-02831-yHighly pathogenic avian influenzaH5N8Iraqi Kurdistan Region |
| spellingShingle | Nahla Muhammad Saeed Peshnyar Muhammad Atta Rashid Hiewa Othman Dyary Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018 BMC Veterinary Research Highly pathogenic avian influenza H5N8 Iraqi Kurdistan Region |
| title | Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018 |
| title_full | Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018 |
| title_fullStr | Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018 |
| title_full_unstemmed | Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018 |
| title_short | Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018 |
| title_sort | genetic characterization of highly pathogenic avian influenza a h5n8 virus isolated from domestic geese in iraq 2018 |
| topic | Highly pathogenic avian influenza H5N8 Iraqi Kurdistan Region |
| url | https://doi.org/10.1186/s12917-021-02831-y |
| work_keys_str_mv | AT nahlamuhammadsaeed geneticcharacterizationofhighlypathogenicavianinfluenzaah5n8virusisolatedfromdomesticgeeseiniraq2018 AT peshnyarmuhammadattarashid geneticcharacterizationofhighlypathogenicavianinfluenzaah5n8virusisolatedfromdomesticgeeseiniraq2018 AT hiewaothmandyary geneticcharacterizationofhighlypathogenicavianinfluenzaah5n8virusisolatedfromdomesticgeeseiniraq2018 |