Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases
<p>Abstract</p> <p>Background</p> <p>We prospectively reviewed response rates, local control, and side effects after non-fractionated stereotactic high single-dose body radiation therapy for lung tumors.</p> <p>Methods</p> <p>Fifty-eight patients...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2006-08-01
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| Series: | Radiation Oncology |
| Online Access: | http://www.ro-journal.com/content/1/1/30 |
| _version_ | 1819135479883235328 |
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| author | Fritz Peter Kraus Hans-Jörg Mühlnickel Werner Hammer Udo Dölken Wolfram Engel-Riedel Walburga Chemaissani Assad Stoelben Erich |
| author_facet | Fritz Peter Kraus Hans-Jörg Mühlnickel Werner Hammer Udo Dölken Wolfram Engel-Riedel Walburga Chemaissani Assad Stoelben Erich |
| author_sort | Fritz Peter |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>We prospectively reviewed response rates, local control, and side effects after non-fractionated stereotactic high single-dose body radiation therapy for lung tumors.</p> <p>Methods</p> <p>Fifty-eight patients underwent radiosurgery involving single-dose irradiation. With 25 patients, 31 metastases in the lungs were irradiated; with each of 33 patients, stage I non-small cell lung cancer (NSCLC) was subject to irradiation. The standard dose prescribed to the isocenter was 30 Gy with an axial safety margin of 10 mm and a longitudinal safety margin of 15 mm. The planning target volume (PTV) was defined using three CT scans with reference to the phases of respiration so that the movement span of the clinical target volume (CTV) was enclosed.</p> <p>Results</p> <p>The volume of the metastases (CTV) varied from 2.8 to 55.8 cm<sup>3 </sup>(median: 6.0 cm<sup>3</sup>) and the PTV varied from 12.2 to 184.0 cm<sup>3 </sup>(median: 45.0 cm<sup>3</sup>). The metastases ranged from 0.7 to 4.5 cm in largest diameter. The volume of the bronchial carcinomas varied from 4.2 to 125.4 cm<sup>3</sup>(median: 17.5 cm<sup>3</sup>) and the PTV from 15.6 to 387.3 cm<sup>3 </sup>(median: 99.8 cm<sup>3</sup>). The bronchial carcinomas ranged from 1.7 to 10 cm in largest diameter. Follow-up periods varied from 6.8 to 63 months (median: 22 months for metastases and 18 months for NSCLC). Local control was achieved with 94% of NSCLC and 87% of metastases. No serious symptomatic side effects were observed. According to the Kaplan-Meier method the overall survival probability rates of patients with lung metastases were as follows: 1 year: 97%, 2 years: 73%, 3 years: 42%, 4 years: 42%, 5 years: 42% (median survival: 26 months); of those with NSCLC: 1 year: 83%, 2 years: 63%, 3 years: 53%, 4 years: 39%: (median survival: 20.4 months).</p> <p>Conclusion</p> <p>Non-fractionated single-dose irradiation of metastases in the lungs or of small, peripheral bronchial carcinomas is an effective and safe form of local treatment and might become a viable alternative to invasive techniques.</p> |
| first_indexed | 2024-12-22T10:19:45Z |
| format | Article |
| id | doaj.art-f600a0f4524940f394958f2b2312225f |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-22T10:19:45Z |
| publishDate | 2006-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-f600a0f4524940f394958f2b2312225f2022-12-21T18:29:40ZengBMCRadiation Oncology1748-717X2006-08-01113010.1186/1748-717X-1-30Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastasesFritz PeterKraus Hans-JörgMühlnickel WernerHammer UdoDölken WolframEngel-Riedel WalburgaChemaissani AssadStoelben Erich<p>Abstract</p> <p>Background</p> <p>We prospectively reviewed response rates, local control, and side effects after non-fractionated stereotactic high single-dose body radiation therapy for lung tumors.</p> <p>Methods</p> <p>Fifty-eight patients underwent radiosurgery involving single-dose irradiation. With 25 patients, 31 metastases in the lungs were irradiated; with each of 33 patients, stage I non-small cell lung cancer (NSCLC) was subject to irradiation. The standard dose prescribed to the isocenter was 30 Gy with an axial safety margin of 10 mm and a longitudinal safety margin of 15 mm. The planning target volume (PTV) was defined using three CT scans with reference to the phases of respiration so that the movement span of the clinical target volume (CTV) was enclosed.</p> <p>Results</p> <p>The volume of the metastases (CTV) varied from 2.8 to 55.8 cm<sup>3 </sup>(median: 6.0 cm<sup>3</sup>) and the PTV varied from 12.2 to 184.0 cm<sup>3 </sup>(median: 45.0 cm<sup>3</sup>). The metastases ranged from 0.7 to 4.5 cm in largest diameter. The volume of the bronchial carcinomas varied from 4.2 to 125.4 cm<sup>3</sup>(median: 17.5 cm<sup>3</sup>) and the PTV from 15.6 to 387.3 cm<sup>3 </sup>(median: 99.8 cm<sup>3</sup>). The bronchial carcinomas ranged from 1.7 to 10 cm in largest diameter. Follow-up periods varied from 6.8 to 63 months (median: 22 months for metastases and 18 months for NSCLC). Local control was achieved with 94% of NSCLC and 87% of metastases. No serious symptomatic side effects were observed. According to the Kaplan-Meier method the overall survival probability rates of patients with lung metastases were as follows: 1 year: 97%, 2 years: 73%, 3 years: 42%, 4 years: 42%, 5 years: 42% (median survival: 26 months); of those with NSCLC: 1 year: 83%, 2 years: 63%, 3 years: 53%, 4 years: 39%: (median survival: 20.4 months).</p> <p>Conclusion</p> <p>Non-fractionated single-dose irradiation of metastases in the lungs or of small, peripheral bronchial carcinomas is an effective and safe form of local treatment and might become a viable alternative to invasive techniques.</p>http://www.ro-journal.com/content/1/1/30 |
| spellingShingle | Fritz Peter Kraus Hans-Jörg Mühlnickel Werner Hammer Udo Dölken Wolfram Engel-Riedel Walburga Chemaissani Assad Stoelben Erich Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases Radiation Oncology |
| title | Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases |
| title_full | Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases |
| title_fullStr | Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases |
| title_full_unstemmed | Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases |
| title_short | Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases |
| title_sort | stereotactic single dose irradiation of stage i non small cell lung cancer and lung metastases |
| url | http://www.ro-journal.com/content/1/1/30 |
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