Potential Role of Probiotics for Inflammaging: A Narrative Review
Background and aims: Inflammaging, a chronic, low-grade inflammation (LGI), is one of the mechanisms of adaptation of an organism to aging. Alterations in the composition of gut microbiota and gut permeability are among the main sources of LGI. They may be modulated by supplementation with live micr...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/9/2919 |
| _version_ | 1797517837266321408 |
|---|---|
| author | Nikolina Jukic Peladic Giuseppina Dell’Aquila Barbara Carrieri Marcello Maggio Antonio Cherubini Paolo Orlandoni |
| author_facet | Nikolina Jukic Peladic Giuseppina Dell’Aquila Barbara Carrieri Marcello Maggio Antonio Cherubini Paolo Orlandoni |
| author_sort | Nikolina Jukic Peladic |
| collection | DOAJ |
| description | Background and aims: Inflammaging, a chronic, low-grade inflammation (LGI), is one of the mechanisms of adaptation of an organism to aging. Alterations in the composition of gut microbiota and gut permeability are among the main sources of LGI. They may be modulated by supplementation with live microorganisms, i.e. probiotics. This narrative review was performed with the aim to critically examine the current evidence from randomized clinical trials (RCTs) on the effects of probiotics on pro-inflammatory and anti-inflammatory cytokines and C-reactive protein (CRP) in healthy older subjects. Methodology: RCTs on the effects of probiotics on inflammatory parameters in subjects older than 65 years published in English and Italian from 1990 to October 2020 were searched in PubMed. Studies that were not RCTs, those using probiotics together with prebiotics (synbiotics), and studies performed in subjects with acute or chronic diseases were excluded. The findings of RCTs were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results: A total of nine RCTs met the eligibility criteria and were included in this narrative review. Four articles reported that probiotic supplementation significantly affected inflammatory parameters, respectively, by reducing TGF-β1 concentrations, IL-8, increasing IL-5 and Il-10, and IFN-γ and IL-12. Conclusions: Based on this narrative review, probiotic supplementation showed a limited effect on inflammatory markers in healthy individuals older than 65 years. Besides being few, the studies analyzed have methodological limitations, are heterogeneous, and provide results which are incomparable. |
| first_indexed | 2024-03-10T07:21:46Z |
| format | Article |
| id | doaj.art-f602db5761574f5d858cd0da2740b1ab |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T07:21:46Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f602db5761574f5d858cd0da2740b1ab2023-11-22T14:34:27ZengMDPI AGNutrients2072-66432021-08-01139291910.3390/nu13092919Potential Role of Probiotics for Inflammaging: A Narrative ReviewNikolina Jukic Peladic0Giuseppina Dell’Aquila1Barbara Carrieri2Marcello Maggio3Antonio Cherubini4Paolo Orlandoni5Clinical Nutrition, IRCCS INRCA Ancona, 60127 Ancona, ItalyGeriatria, Accettazione Geriatrica e Centro di Ricerca per L’invecchiamento, IRCCS INRCA, 60127 Ancona, ItalyGeriatria, Accettazione Geriatrica e Centro di Ricerca per L’invecchiamento, IRCCS INRCA, 60127 Ancona, ItalyDepartment of Medicine and Surgery, University Medical School of Parma, 43121 Parma, ItalyGeriatria, Accettazione Geriatrica e Centro di Ricerca per L’invecchiamento, IRCCS INRCA, 60127 Ancona, ItalyClinical Nutrition, IRCCS INRCA Ancona, 60127 Ancona, ItalyBackground and aims: Inflammaging, a chronic, low-grade inflammation (LGI), is one of the mechanisms of adaptation of an organism to aging. Alterations in the composition of gut microbiota and gut permeability are among the main sources of LGI. They may be modulated by supplementation with live microorganisms, i.e. probiotics. This narrative review was performed with the aim to critically examine the current evidence from randomized clinical trials (RCTs) on the effects of probiotics on pro-inflammatory and anti-inflammatory cytokines and C-reactive protein (CRP) in healthy older subjects. Methodology: RCTs on the effects of probiotics on inflammatory parameters in subjects older than 65 years published in English and Italian from 1990 to October 2020 were searched in PubMed. Studies that were not RCTs, those using probiotics together with prebiotics (synbiotics), and studies performed in subjects with acute or chronic diseases were excluded. The findings of RCTs were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results: A total of nine RCTs met the eligibility criteria and were included in this narrative review. Four articles reported that probiotic supplementation significantly affected inflammatory parameters, respectively, by reducing TGF-β1 concentrations, IL-8, increasing IL-5 and Il-10, and IFN-γ and IL-12. Conclusions: Based on this narrative review, probiotic supplementation showed a limited effect on inflammatory markers in healthy individuals older than 65 years. Besides being few, the studies analyzed have methodological limitations, are heterogeneous, and provide results which are incomparable.https://www.mdpi.com/2072-6643/13/9/2919inflammagingprobioticsaginghealthy older subjects |
| spellingShingle | Nikolina Jukic Peladic Giuseppina Dell’Aquila Barbara Carrieri Marcello Maggio Antonio Cherubini Paolo Orlandoni Potential Role of Probiotics for Inflammaging: A Narrative Review Nutrients inflammaging probiotics aging healthy older subjects |
| title | Potential Role of Probiotics for Inflammaging: A Narrative Review |
| title_full | Potential Role of Probiotics for Inflammaging: A Narrative Review |
| title_fullStr | Potential Role of Probiotics for Inflammaging: A Narrative Review |
| title_full_unstemmed | Potential Role of Probiotics for Inflammaging: A Narrative Review |
| title_short | Potential Role of Probiotics for Inflammaging: A Narrative Review |
| title_sort | potential role of probiotics for inflammaging a narrative review |
| topic | inflammaging probiotics aging healthy older subjects |
| url | https://www.mdpi.com/2072-6643/13/9/2919 |
| work_keys_str_mv | AT nikolinajukicpeladic potentialroleofprobioticsforinflammaginganarrativereview AT giuseppinadellaquila potentialroleofprobioticsforinflammaginganarrativereview AT barbaracarrieri potentialroleofprobioticsforinflammaginganarrativereview AT marcellomaggio potentialroleofprobioticsforinflammaginganarrativereview AT antoniocherubini potentialroleofprobioticsforinflammaginganarrativereview AT paoloorlandoni potentialroleofprobioticsforinflammaginganarrativereview |