RNF213 p.R4810K (c.14429G > A) Variant Determines Anatomical Variations of the Circle of Willis in Cerebrovascular Disease

RNF213 p.R4810K (c.14429G > A) Variant Determines Anatomical Variations of the Circle of Willis in Cerebrovascular Disease

IntroductionDysregulation of the RING finger protein 213 (RNF213) gene impairs vascular formation in experimental animal models. In addition, vascular abnormalities in the circle of Willis are associated with cerebrovascular disease. Here, we evaluated the relationship between the East Asian founder...

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Bibliographic Details
Main Authors: Futoshi Eto, Takeshi Yoshimoto, Shuhei Okazaki, Kunihiro Nishimura, Shiori Ogura, Eriko Yamaguchi, Kazuki Fukuma, Satoshi Saito, Kazuo Washida, Masatoshi Koga, Kazunori Toyoda, Takaaki Morimoto, Hirofumi Maruyama, Akio Koizumi, Masafumi Ihara
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
RNF213 p.R4810K
the circle of Willis
cerebral circulation
magnetic resonance angiography
single nucleotide polymorphism
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.681743/full

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