Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

Abstract We previously identified a TCR Vβ21 T cell clone which was specific to CML patients, and demonstrated that TCR Vα13/β21 gene-modified CD3+ T cells had specific cytotoxicity for HLA-A11+ K562 cells. However, it remains unclear which antigen is specifically recognized by the TCR Vβ21 T cell c...

Full description

Bibliographic Details
Main Authors: Yikai Zhang, Ling Xu, Shaohua Chen, Xianfeng Zha, Wei Wei, Yangqiu Li
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Biomarker Research
Subjects:
Chronic myelogenous leukemia
Wilms tumor 1
BCR-ABL
T cell repertoire
T-cell receptor beta-chain sequencing
Online Access:http://link.springer.com/article/10.1186/s40364-019-0163-1

Similar Items

Similar Items