Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer
Nanomedicines receive great attention in cancer treatment. Nevertheless, nonbiodegradable and long-term retention still limit their clinical translation. Herein, we successfully synthesize a hypoxia-triggered degradable porphyrinic covalent organic framework (HPCOF) for antitumor therapy in vivo. HP...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424000401 |
| _version_ | 1797258694778421248 |
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| author | Yulong Liu Kang Yang Jun Wang Yanzhang Tian Bin Song Ruiping Zhang |
| author_facet | Yulong Liu Kang Yang Jun Wang Yanzhang Tian Bin Song Ruiping Zhang |
| author_sort | Yulong Liu |
| collection | DOAJ |
| description | Nanomedicines receive great attention in cancer treatment. Nevertheless, nonbiodegradable and long-term retention still limit their clinical translation. Herein, we successfully synthesize a hypoxia-triggered degradable porphyrinic covalent organic framework (HPCOF) for antitumor therapy in vivo. HPCOF possesses wide absorption in near infrared region (NIR) which endows HPCOF excellent photothermal conversion efficiency and photoacoustic (PA) imaging ability. Moreover, HPCOF exhibits excellent photodynamic and photothermal effect under special-wavelength laser irradiation. For the first time, the in vitro and in vivo tests demonstrate that HPCOF shows effective therapeutic effect for the combination of PDT and PTT under the monitoring of PA imaging. Importantly, in tumor region, HPCOF could be triggered by hypoxia microenvironment and collapsed gradually, then cleared from the body after treatment. This work fabricates a novel COF for cancer treatment and testifies great potential of HPCOF in clinical application with reducing long-term toxicity. |
| first_indexed | 2024-03-08T04:51:11Z |
| format | Article |
| id | doaj.art-f606281bc0ff4d96b9d01c949c6db69f |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-24T22:57:37Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-f606281bc0ff4d96b9d01c949c6db69f2024-03-18T04:34:21ZengElsevierMaterials Today Bio2590-00642024-04-0125100981Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancerYulong Liu0Kang Yang1Jun Wang2Yanzhang Tian3Bin Song4Ruiping Zhang5General Surgery Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China; Shanxi Medical University, Taiyuan, 030001, ChinaShanxi Medical University, Taiyuan, 030001, ChinaGeneral Surgery Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, ChinaGeneral Surgery Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, ChinaGeneral Surgery Department, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, ChinaThe Radiology Department of Shanxi Provincial People’ Hospital, Five Hospital of Shanxi Medical University, Taiyuan, 030001, China; Corresponding author. The Radiology Department of Shanxi Provincial People’ Hospital, Five Hospital of Shanxi Medical University, Taiyuan, 030001, China.Nanomedicines receive great attention in cancer treatment. Nevertheless, nonbiodegradable and long-term retention still limit their clinical translation. Herein, we successfully synthesize a hypoxia-triggered degradable porphyrinic covalent organic framework (HPCOF) for antitumor therapy in vivo. HPCOF possesses wide absorption in near infrared region (NIR) which endows HPCOF excellent photothermal conversion efficiency and photoacoustic (PA) imaging ability. Moreover, HPCOF exhibits excellent photodynamic and photothermal effect under special-wavelength laser irradiation. For the first time, the in vitro and in vivo tests demonstrate that HPCOF shows effective therapeutic effect for the combination of PDT and PTT under the monitoring of PA imaging. Importantly, in tumor region, HPCOF could be triggered by hypoxia microenvironment and collapsed gradually, then cleared from the body after treatment. This work fabricates a novel COF for cancer treatment and testifies great potential of HPCOF in clinical application with reducing long-term toxicity.http://www.sciencedirect.com/science/article/pii/S2590006424000401Covalent organic frameworkHypoxia triggeredDegradablePhotoacoustic imagingPhotodynamic/photothermal synergistic therapy |
| spellingShingle | Yulong Liu Kang Yang Jun Wang Yanzhang Tian Bin Song Ruiping Zhang Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer Materials Today Bio Covalent organic framework Hypoxia triggered Degradable Photoacoustic imaging Photodynamic/photothermal synergistic therapy |
| title | Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer |
| title_full | Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer |
| title_fullStr | Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer |
| title_full_unstemmed | Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer |
| title_short | Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer |
| title_sort | hypoxia triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer |
| topic | Covalent organic framework Hypoxia triggered Degradable Photoacoustic imaging Photodynamic/photothermal synergistic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424000401 |
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