LATE DYSFUNCTION OF THE GRAFTED KIDNEY: CAUSES, MORPHOLOGICAL STRUCTURE, PROPHYLAXIS AND TREATMENT
The most important causes of late renal graft dysfunction (late acute rejection, chronic rejection, chronic neph- rotoxicity induced by calcineurin inhibitors (CNI) and nonspecific nephrosclerosis), their morphological charac- teristics and the current approaches to their treatment are considered. O...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2009-05-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/254 |
| _version_ | 1797872110981349376 |
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| author | E. S. Stolyarevich N. A. Tomilina |
| author_facet | E. S. Stolyarevich N. A. Tomilina |
| author_sort | E. S. Stolyarevich |
| collection | DOAJ |
| description | The most important causes of late renal graft dysfunction (late acute rejection, chronic rejection, chronic neph- rotoxicity induced by calcineurin inhibitors (CNI) and nonspecific nephrosclerosis), their morphological charac- teristics and the current approaches to their treatment are considered. One of the ways to influence the prevention and the course of late acute rejection which is under discussion in literature is the conversion from cyclosporine A to tacrolimus. The switch from standart to low dosage cyclosporine in combination with proliferative signal in- hibitors (sirolimus, everolimus) is considered as a way to prevent the progression of nephrosclerosis due to CNI- nephrotoxicity. In cases where the main cause of the late kidney graft dysfunction is nonspecific nephrosclerosis the treatment with ACE-inhibitors and optimization with CNI-dosage may be recommended. |
| first_indexed | 2024-04-10T00:54:42Z |
| format | Article |
| id | doaj.art-f606beb1d0584cc99473f037794a5a76 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:54:42Z |
| publishDate | 2009-05-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-f606beb1d0584cc99473f037794a5a762023-03-13T10:37:19ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912009-05-0111311412210.15825/1995-1191-2009-3-114-122197LATE DYSFUNCTION OF THE GRAFTED KIDNEY: CAUSES, MORPHOLOGICAL STRUCTURE, PROPHYLAXIS AND TREATMENTE. S. Stolyarevich0N. A. Tomilina1Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowThe most important causes of late renal graft dysfunction (late acute rejection, chronic rejection, chronic neph- rotoxicity induced by calcineurin inhibitors (CNI) and nonspecific nephrosclerosis), their morphological charac- teristics and the current approaches to their treatment are considered. One of the ways to influence the prevention and the course of late acute rejection which is under discussion in literature is the conversion from cyclosporine A to tacrolimus. The switch from standart to low dosage cyclosporine in combination with proliferative signal in- hibitors (sirolimus, everolimus) is considered as a way to prevent the progression of nephrosclerosis due to CNI- nephrotoxicity. In cases where the main cause of the late kidney graft dysfunction is nonspecific nephrosclerosis the treatment with ACE-inhibitors and optimization with CNI-dosage may be recommended.https://journal.transpl.ru/vtio/article/view/254kidney transplantationlate graft dysfunctionimmunosupression |
| spellingShingle | E. S. Stolyarevich N. A. Tomilina LATE DYSFUNCTION OF THE GRAFTED KIDNEY: CAUSES, MORPHOLOGICAL STRUCTURE, PROPHYLAXIS AND TREATMENT Vestnik Transplantologii i Iskusstvennyh Organov kidney transplantation late graft dysfunction immunosupression |
| title | LATE DYSFUNCTION OF THE GRAFTED KIDNEY: CAUSES, MORPHOLOGICAL STRUCTURE, PROPHYLAXIS AND TREATMENT |
| title_full | LATE DYSFUNCTION OF THE GRAFTED KIDNEY: CAUSES, MORPHOLOGICAL STRUCTURE, PROPHYLAXIS AND TREATMENT |
| title_fullStr | LATE DYSFUNCTION OF THE GRAFTED KIDNEY: CAUSES, MORPHOLOGICAL STRUCTURE, PROPHYLAXIS AND TREATMENT |
| title_full_unstemmed | LATE DYSFUNCTION OF THE GRAFTED KIDNEY: CAUSES, MORPHOLOGICAL STRUCTURE, PROPHYLAXIS AND TREATMENT |
| title_short | LATE DYSFUNCTION OF THE GRAFTED KIDNEY: CAUSES, MORPHOLOGICAL STRUCTURE, PROPHYLAXIS AND TREATMENT |
| title_sort | late dysfunction of the grafted kidney causes morphological structure prophylaxis and treatment |
| topic | kidney transplantation late graft dysfunction immunosupression |
| url | https://journal.transpl.ru/vtio/article/view/254 |
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