EFFICACY AND SAFETY OF PIDOTIMOD IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN
<em>The immunomodulating activity of pidotimod (imunorix) was evaluated in a doublebblind, placebobcontrolled, randomized, multicentre trial, on 120 pediatric patients affected by recurrent respiratory infections. Antibiotic therapy and time of hospitalization were shorter in the patients taki...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2008-01-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | http://vsp.spr-journal.ru:80/jour/article/view/1371 |
| _version_ | 1797724880192405504 |
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| author | G. Caramia E. Clemente R. Solli V. Mei R. Cera V. Carnelli V. Venturoli A. Corsini |
| author_facet | G. Caramia E. Clemente R. Solli V. Mei R. Cera V. Carnelli V. Venturoli A. Corsini |
| author_sort | G. Caramia |
| collection | DOAJ |
| description | <em>The immunomodulating activity of pidotimod (imunorix) was evaluated in a doublebblind, placebobcontrolled, randomized, multicentre trial, on 120 pediatric patients affected by recurrent respiratory infections. Antibiotic therapy and time of hospitalization were shorter in the patients taking pidotimod, and clinical recovery began more rapidly. A significant trend to normalization of the immune response, evidenced by chemotaxis and leukocyte phagocytosis index, was found only in patients treated with pidotimod. A significant decrease in the risk of relapses was observed in patients treated with pidotimod (35%), as well as a reduction of hospitalization (86%) and a decreased antibiotic therapy (47%). If a relapse occurred, the response of treated patients was quicker (fever, antibiotic therapy, hospitalization). No side effects, including significant alterations in main laboratory parameters were observed. The management of children with recurrent respiratory infections with pidotimod reduces the duration and severity of acute condition of infections and risk of relapse. pidotimod is well tolerated and maintains beneficial effect of treatment.</em><br /><strong><em>Key words: children, pidotimod, recurrent respiratory infections, management.</em></strong> |
| first_indexed | 2024-03-12T10:23:12Z |
| format | Article |
| id | doaj.art-f60834655b9e4d0a885873c77efbfe1d |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T10:23:12Z |
| publishDate | 2008-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-f60834655b9e4d0a885873c77efbfe1d2023-09-02T09:57:22Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352008-01-017272761371EFFICACY AND SAFETY OF PIDOTIMOD IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTIONS IN CHILDRENG. Caramia0E. Clemente1R. Solli2V. Mei3R. Cera4V. Carnelli5V. Venturoli6A. Corsini7Pediatric Department, Ospedale dei Bambini G. Galilei, MilanPediatric Department, Ospedale dei Bambini G. Galilei, MilanPediatric Department, Ospedale dei Bambini G. Galilei, MilanPediatric Department, Ospedale dei Bambini G. Galilei, MilanPediatric Department, Ospedale dei Bambini G. Galilei, MilanPediatric Department, Ospedale dei Bambini G. Galilei, MilanPediatric Department, Ospedale dei Bambini G. Galilei, MilanPediatric Department, Ospedale dei Bambini G. Galilei, Milan<em>The immunomodulating activity of pidotimod (imunorix) was evaluated in a doublebblind, placebobcontrolled, randomized, multicentre trial, on 120 pediatric patients affected by recurrent respiratory infections. Antibiotic therapy and time of hospitalization were shorter in the patients taking pidotimod, and clinical recovery began more rapidly. A significant trend to normalization of the immune response, evidenced by chemotaxis and leukocyte phagocytosis index, was found only in patients treated with pidotimod. A significant decrease in the risk of relapses was observed in patients treated with pidotimod (35%), as well as a reduction of hospitalization (86%) and a decreased antibiotic therapy (47%). If a relapse occurred, the response of treated patients was quicker (fever, antibiotic therapy, hospitalization). No side effects, including significant alterations in main laboratory parameters were observed. The management of children with recurrent respiratory infections with pidotimod reduces the duration and severity of acute condition of infections and risk of relapse. pidotimod is well tolerated and maintains beneficial effect of treatment.</em><br /><strong><em>Key words: children, pidotimod, recurrent respiratory infections, management.</em></strong>http://vsp.spr-journal.ru:80/jour/article/view/1371childrenpidotimodrecurrent respiratory infectionsmanagement |
| spellingShingle | G. Caramia E. Clemente R. Solli V. Mei R. Cera V. Carnelli V. Venturoli A. Corsini EFFICACY AND SAFETY OF PIDOTIMOD IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN Вопросы современной педиатрии children pidotimod recurrent respiratory infections management |
| title | EFFICACY AND SAFETY OF PIDOTIMOD IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN |
| title_full | EFFICACY AND SAFETY OF PIDOTIMOD IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN |
| title_fullStr | EFFICACY AND SAFETY OF PIDOTIMOD IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN |
| title_full_unstemmed | EFFICACY AND SAFETY OF PIDOTIMOD IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN |
| title_short | EFFICACY AND SAFETY OF PIDOTIMOD IN THE TREATMENT OF RECURRENT RESPIRATORY INFECTIONS IN CHILDREN |
| title_sort | efficacy and safety of pidotimod in the treatment of recurrent respiratory infections in children |
| topic | children pidotimod recurrent respiratory infections management |
| url | http://vsp.spr-journal.ru:80/jour/article/view/1371 |
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