Efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia: A meta-analysis of randomized controlled trials
It is still controversial whether glue can be used for mesh fixation in laparoscopic inguinal hernia repair. The aim of this meta-analysis was used to systematically evaluate the effectiveness and safety of glue mesh fixation in laparoscopic tension-free inguinal hernia repair. The PubMed database,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958423004530 |
| _version_ | 1827855747432579072 |
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| author | Nan Hu Hong Xie Deng-Chao Wang Yue-Hua Lei Jian Wei Miao Yu Yue-Juan Li |
| author_facet | Nan Hu Hong Xie Deng-Chao Wang Yue-Hua Lei Jian Wei Miao Yu Yue-Juan Li |
| author_sort | Nan Hu |
| collection | DOAJ |
| description | It is still controversial whether glue can be used for mesh fixation in laparoscopic inguinal hernia repair. The aim of this meta-analysis was used to systematically evaluate the effectiveness and safety of glue mesh fixation in laparoscopic tension-free inguinal hernia repair. The PubMed database, EMBASE database and Cochrane Library were searched to collect published randomized controlled trials (RCTs) on laparoscopic tension-free inguinal hernia repair with glue mesh fixation. Sixteen RCTs and 2409 patients with inguinal hernia were included. The meta-analysis showed that compared with the mechanical mesh fixation group(MMFG), the glue mesh fixation group(GMFG) had significantly reduced incidences of chronic pain[relative risk (RR) = 0.40, 95% confidence interval (CI) (0.28,0.57), P < 0.00001], urinary retention[RR = 0.53, 95% CI(0.29,0.97), P = 0.04], haematoma[RR = 0.23, 95% CI(0.09,0.58), P = 0.002] and total complications[RR = 0.28, 95% CI(0.18,0.44), P < 0.00001]; there were no significant differences in pain score on postoperative day 1[MD = −1.33, 95% CI(-2.93,0.26), P = 0.10], operation time[MD = 1.46, 95% CI(-3.97,6.88), P = 0.60] and recurrence rate[RR = 0.72, 95% CI(0.35,1.47), P = 0.37] between the two groups. In conclusion, the application of glue mesh fixation in laparoscopic inguinal hernia repair is safe and reliable with fewer complications. Moreover, it can reduce the incidence of chronic pain without increasing the recurrence rate. However, due to the small number of cases in this analysis and limitations in the quality of the included studies, the findings need to be further verified by multicentre, large-sample and high-quality RCTs in the future. |
| first_indexed | 2024-03-12T11:54:47Z |
| format | Article |
| id | doaj.art-f609cb14ea8b4744a6ea12cbad8387e9 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-03-12T11:54:47Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-f609cb14ea8b4744a6ea12cbad8387e92023-08-31T05:00:50ZengElsevierAsian Journal of Surgery1015-95842023-09-0146934173425Efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia: A meta-analysis of randomized controlled trialsNan Hu0Hong Xie1Deng-Chao Wang2Yue-Hua Lei3Jian Wei4Miao Yu5Yue-Juan Li6Department of General Surgery, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan, ChinaDepartment of General Medicine, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan, ChinaDepartment of General Surgery, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan, China; Corresponding author. Department of General Surgery, Zigong Fourth People's Hospital, 19 Tanmulin Road, Zigong, Sichuan, 643000, PR China.Department of General Surgery, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan, ChinaDepartment of General Surgery, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan, ChinaDepartment of Basic Medicine, Sichuan Vocational College of Health and Rehabilitation, Zigong, 643000, Sichuan, ChinaDepartment of General Surgery, Zigong Fourth People's Hospital, Zigong, 643000, Sichuan, ChinaIt is still controversial whether glue can be used for mesh fixation in laparoscopic inguinal hernia repair. The aim of this meta-analysis was used to systematically evaluate the effectiveness and safety of glue mesh fixation in laparoscopic tension-free inguinal hernia repair. The PubMed database, EMBASE database and Cochrane Library were searched to collect published randomized controlled trials (RCTs) on laparoscopic tension-free inguinal hernia repair with glue mesh fixation. Sixteen RCTs and 2409 patients with inguinal hernia were included. The meta-analysis showed that compared with the mechanical mesh fixation group(MMFG), the glue mesh fixation group(GMFG) had significantly reduced incidences of chronic pain[relative risk (RR) = 0.40, 95% confidence interval (CI) (0.28,0.57), P < 0.00001], urinary retention[RR = 0.53, 95% CI(0.29,0.97), P = 0.04], haematoma[RR = 0.23, 95% CI(0.09,0.58), P = 0.002] and total complications[RR = 0.28, 95% CI(0.18,0.44), P < 0.00001]; there were no significant differences in pain score on postoperative day 1[MD = −1.33, 95% CI(-2.93,0.26), P = 0.10], operation time[MD = 1.46, 95% CI(-3.97,6.88), P = 0.60] and recurrence rate[RR = 0.72, 95% CI(0.35,1.47), P = 0.37] between the two groups. In conclusion, the application of glue mesh fixation in laparoscopic inguinal hernia repair is safe and reliable with fewer complications. Moreover, it can reduce the incidence of chronic pain without increasing the recurrence rate. However, due to the small number of cases in this analysis and limitations in the quality of the included studies, the findings need to be further verified by multicentre, large-sample and high-quality RCTs in the future.http://www.sciencedirect.com/science/article/pii/S1015958423004530GlueInguinal herniaLaparoscopicMesh fixationMeta-analysis |
| spellingShingle | Nan Hu Hong Xie Deng-Chao Wang Yue-Hua Lei Jian Wei Miao Yu Yue-Juan Li Efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia: A meta-analysis of randomized controlled trials Asian Journal of Surgery Glue Inguinal hernia Laparoscopic Mesh fixation Meta-analysis |
| title | Efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia: A meta-analysis of randomized controlled trials |
| title_full | Efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia: A meta-analysis of randomized controlled trials |
| title_fullStr | Efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia: A meta-analysis of randomized controlled trials |
| title_full_unstemmed | Efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia: A meta-analysis of randomized controlled trials |
| title_short | Efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia: A meta-analysis of randomized controlled trials |
| title_sort | efficacy and safety of glue mesh fixation for laparoscopic inguinal hernia a meta analysis of randomized controlled trials |
| topic | Glue Inguinal hernia Laparoscopic Mesh fixation Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1015958423004530 |
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