Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up
Breastfeeding (BF) is the gold standard in infant nutrition; knowing how it influences brain connectivity would help understand the mechanisms involved, which would help close the nutritional gap between infant formulas and breast milk. We analyzed potential long-term differences depending on the di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.935740/full |
| _version_ | 1811239184914972672 |
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| author | Estefanía Diéguez Estefanía Diéguez Estefanía Diéguez Ana Nieto-Ruiz Ana Nieto-Ruiz Ana Nieto-Ruiz Cristina Martín-Pérez Natalia Sepúlveda-Valbuena Florian Herrmann Florian Herrmann Jesús Jiménez Roser De-Castellar Andrés Catena José Antonio García-Santos José Antonio García-Santos José Antonio García-Santos Mercedes G. Bermúdez Mercedes G. Bermúdez Mercedes G. Bermúdez Cristina Campoy Cristina Campoy Cristina Campoy Cristina Campoy |
| author_facet | Estefanía Diéguez Estefanía Diéguez Estefanía Diéguez Ana Nieto-Ruiz Ana Nieto-Ruiz Ana Nieto-Ruiz Cristina Martín-Pérez Natalia Sepúlveda-Valbuena Florian Herrmann Florian Herrmann Jesús Jiménez Roser De-Castellar Andrés Catena José Antonio García-Santos José Antonio García-Santos José Antonio García-Santos Mercedes G. Bermúdez Mercedes G. Bermúdez Mercedes G. Bermúdez Cristina Campoy Cristina Campoy Cristina Campoy Cristina Campoy |
| author_sort | Estefanía Diéguez |
| collection | DOAJ |
| description | Breastfeeding (BF) is the gold standard in infant nutrition; knowing how it influences brain connectivity would help understand the mechanisms involved, which would help close the nutritional gap between infant formulas and breast milk. We analyzed potential long-term differences depending on the diet with an experimental infant formula (EF), compared to a standard infant formula (SF) or breastfeeding (BF) during the first 18 months of life on children's hypothalamic functional connectivity (FC) assessed at 6 years old. A total of 62 children participating in the COGNIS randomized clinical trial (Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT02094547) were included in this study. They were randomized to receive an SF (n = 22) or a bioactive nutrient-enriched EF (n = 20). BF children were also included as a control study group (BF: n = 20). Brain function was evaluated using functional magnetic resonance imaging (fMRI) and mean glucose levels were collected through a 24-h continuous glucose monitoring (CGM) device at 6 years old. Furthermore, nutrient intake was also analyzed during the first 18 months of life and at 6 years old through 3-day dietary intake records. Groups fed with EF and BF showed lower FC between the medial hypothalamus (MH) and the anterior cingulate cortex (ACC) in comparison with SF-fed children. Moreover, the BF children group showed lower FC between the MH and the left putamen extending to the middle insula, and higher FC between the MH and the inferior frontal gyrus (IFG) compared to the EF-fed children group. These areas are key regions within the salience network, which is involved in processing salience stimuli, eating motivation, and hedonic-driven desire to consume food. Indeed, current higher connectivity found on the MH-IFG network in the BF group was associated with lower simple sugars acceptable macronutrient distribution ranges (AMDRs) at 6 months of age. Regarding linoleic acid intake at 12 months old, a negative association with this network (MH-IFG) only in the BF group was found. In addition, BF children showed lower mean glucose levels compared to SF-fed children at 6 years old. Our results may point out a possible relationship between diet during the first 18 months of life and inclined proclivity for hedonic eating later in life.Clinical trial registrationhttps://www.clinicaltrials.gov/, identifier NCT02094547. |
| first_indexed | 2024-04-12T12:55:23Z |
| format | Article |
| id | doaj.art-f60a94a605d944c499e82a9b2d4e841e |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T12:55:23Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-f60a94a605d944c499e82a9b2d4e841e2022-12-22T03:32:21ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-10-01910.3389/fnut.2022.935740935740Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-upEstefanía Diéguez0Estefanía Diéguez1Estefanía Diéguez2Ana Nieto-Ruiz3Ana Nieto-Ruiz4Ana Nieto-Ruiz5Cristina Martín-Pérez6Natalia Sepúlveda-Valbuena7Florian Herrmann8Florian Herrmann9Jesús Jiménez10Roser De-Castellar11Andrés Catena12José Antonio García-Santos13José Antonio García-Santos14José Antonio García-Santos15Mercedes G. Bermúdez16Mercedes G. Bermúdez17Mercedes G. Bermúdez18Cristina Campoy19Cristina Campoy20Cristina Campoy21Cristina Campoy22Department of Paediatrics, School of Medicine, University of Granada, Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, SpainPsychology Department, Faculty of Education, University of Valladolid, Segovia, SpainNutrition and Biochemistry Department, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá, ColombiaDepartment of Paediatrics, School of Medicine, University of Granada, Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, SpainOrdesa Laboratories, S.L., Sant Boi de Llobregat, SpainOrdesa Laboratories, S.L., Sant Boi de Llobregat, SpainDepartment of Experimental Psychology, School of Psychology, University of Granada, Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Granada, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, SpainEURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, SpainNational Network of Research in Epidemiology and Public Health (CIBERESP), Institute of Health Carlos III (Granada's Node), Madrid, SpainBreastfeeding (BF) is the gold standard in infant nutrition; knowing how it influences brain connectivity would help understand the mechanisms involved, which would help close the nutritional gap between infant formulas and breast milk. We analyzed potential long-term differences depending on the diet with an experimental infant formula (EF), compared to a standard infant formula (SF) or breastfeeding (BF) during the first 18 months of life on children's hypothalamic functional connectivity (FC) assessed at 6 years old. A total of 62 children participating in the COGNIS randomized clinical trial (Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT02094547) were included in this study. They were randomized to receive an SF (n = 22) or a bioactive nutrient-enriched EF (n = 20). BF children were also included as a control study group (BF: n = 20). Brain function was evaluated using functional magnetic resonance imaging (fMRI) and mean glucose levels were collected through a 24-h continuous glucose monitoring (CGM) device at 6 years old. Furthermore, nutrient intake was also analyzed during the first 18 months of life and at 6 years old through 3-day dietary intake records. Groups fed with EF and BF showed lower FC between the medial hypothalamus (MH) and the anterior cingulate cortex (ACC) in comparison with SF-fed children. Moreover, the BF children group showed lower FC between the MH and the left putamen extending to the middle insula, and higher FC between the MH and the inferior frontal gyrus (IFG) compared to the EF-fed children group. These areas are key regions within the salience network, which is involved in processing salience stimuli, eating motivation, and hedonic-driven desire to consume food. Indeed, current higher connectivity found on the MH-IFG network in the BF group was associated with lower simple sugars acceptable macronutrient distribution ranges (AMDRs) at 6 months of age. Regarding linoleic acid intake at 12 months old, a negative association with this network (MH-IFG) only in the BF group was found. In addition, BF children showed lower mean glucose levels compared to SF-fed children at 6 years old. Our results may point out a possible relationship between diet during the first 18 months of life and inclined proclivity for hedonic eating later in life.Clinical trial registrationhttps://www.clinicaltrials.gov/, identifier NCT02094547.https://www.frontiersin.org/articles/10.3389/fnut.2022.935740/fullneuroimaginghypothalamusmean glucose levelsmilk fat globule membrane (MFGM)long chain polyunsaturated fatty acids (LC-PUFAs)synbiotics |
| spellingShingle | Estefanía Diéguez Estefanía Diéguez Estefanía Diéguez Ana Nieto-Ruiz Ana Nieto-Ruiz Ana Nieto-Ruiz Cristina Martín-Pérez Natalia Sepúlveda-Valbuena Florian Herrmann Florian Herrmann Jesús Jiménez Roser De-Castellar Andrés Catena José Antonio García-Santos José Antonio García-Santos José Antonio García-Santos Mercedes G. Bermúdez Mercedes G. Bermúdez Mercedes G. Bermúdez Cristina Campoy Cristina Campoy Cristina Campoy Cristina Campoy Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up Frontiers in Nutrition neuroimaging hypothalamus mean glucose levels milk fat globule membrane (MFGM) long chain polyunsaturated fatty acids (LC-PUFAs) synbiotics |
| title | Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up |
| title_full | Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up |
| title_fullStr | Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up |
| title_full_unstemmed | Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up |
| title_short | Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up |
| title_sort | association study between hypothalamic functional connectivity early nutrition and glucose levels in healthy children aged 6 years the cognis study follow up |
| topic | neuroimaging hypothalamus mean glucose levels milk fat globule membrane (MFGM) long chain polyunsaturated fatty acids (LC-PUFAs) synbiotics |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.935740/full |
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