Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study
Abstract Childhood adversity may act as a stressor to produce a cascade of neurobiological effects that irreversibly alter neural development, setting the stage for developing psychopathology in adulthood. The catechol‐O‐methyltransferase (COMT) Val158Met polymorphism has received much attention as...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-12-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1858 |
| _version_ | 1818848173525827584 |
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| author | Tian Tian Jia Li Guiling Zhang Jian Wang Dong Liu Changhua Wan Jicheng Fang Di Wu Yiran Zhou Wenzhen Zhu |
| author_facet | Tian Tian Jia Li Guiling Zhang Jian Wang Dong Liu Changhua Wan Jicheng Fang Di Wu Yiran Zhou Wenzhen Zhu |
| author_sort | Tian Tian |
| collection | DOAJ |
| description | Abstract Childhood adversity may act as a stressor to produce a cascade of neurobiological effects that irreversibly alter neural development, setting the stage for developing psychopathology in adulthood. The catechol‐O‐methyltransferase (COMT) Val158Met polymorphism has received much attention as a candidate gene associated with environmental adversity, modifying risk for psychopathology. In this study, we aim to see how gene × brain × environment models give a more integrative understanding of brain modifications that contribute to predicting psychopathology related to childhood adversity. A large nonclinical sample of young adults completed Childhood Trauma Questionnaire (CTQ), behavioral scores, multimodal magnetic resonance imaging (MRI) scans, and genotyping. We utilized graph‐based connectivity analysis in morphometric similarity mapping and resting‐state functional MRI to investigate brain alterations. Relationships among COMT genotypes, CTQ score, imaging phenotypes, and behavioral scores were identified by multiple regression and mediation effect analysis. Significant main effect of CTQ score was found in anatomic connectivity of orbitofrontal cortex that was an outstanding mediator supporting the relationship between CTQ score and anxiety/harm‐avoiding personality. We also noted the main effect of childhood trauma on reorganization of functional connectivity within the language network. Additionally, we found genotype × CTQ score interactions on functional connectivity of the right frontoparietal network as well as anatomic connectivity of motor and limbic regions. Our data demonstrate childhood adversity and COMT genotypes are associated with abnormal brain connectivity, structurally and functionally. Early identification of individuals at risk, assessment of brain abnormality, and cognitive interventions may help to prevent or limit negative outcomes. |
| first_indexed | 2024-12-19T06:13:08Z |
| format | Article |
| id | doaj.art-f60ab17cdc434daba94471f89ace7d1a |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-19T06:13:08Z |
| publishDate | 2020-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-f60ab17cdc434daba94471f89ace7d1a2022-12-21T20:32:58ZengWileyBrain and Behavior2162-32792020-12-011012n/an/a10.1002/brb3.1858Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI studyTian Tian0Jia Li1Guiling Zhang2Jian Wang3Dong Liu4Changhua Wan5Jicheng Fang6Di Wu7Yiran Zhou8Wenzhen Zhu9Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaTongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaTongji Medical College Huazhong University of Science and Technology Wuhan ChinaTongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaAbstract Childhood adversity may act as a stressor to produce a cascade of neurobiological effects that irreversibly alter neural development, setting the stage for developing psychopathology in adulthood. The catechol‐O‐methyltransferase (COMT) Val158Met polymorphism has received much attention as a candidate gene associated with environmental adversity, modifying risk for psychopathology. In this study, we aim to see how gene × brain × environment models give a more integrative understanding of brain modifications that contribute to predicting psychopathology related to childhood adversity. A large nonclinical sample of young adults completed Childhood Trauma Questionnaire (CTQ), behavioral scores, multimodal magnetic resonance imaging (MRI) scans, and genotyping. We utilized graph‐based connectivity analysis in morphometric similarity mapping and resting‐state functional MRI to investigate brain alterations. Relationships among COMT genotypes, CTQ score, imaging phenotypes, and behavioral scores were identified by multiple regression and mediation effect analysis. Significant main effect of CTQ score was found in anatomic connectivity of orbitofrontal cortex that was an outstanding mediator supporting the relationship between CTQ score and anxiety/harm‐avoiding personality. We also noted the main effect of childhood trauma on reorganization of functional connectivity within the language network. Additionally, we found genotype × CTQ score interactions on functional connectivity of the right frontoparietal network as well as anatomic connectivity of motor and limbic regions. Our data demonstrate childhood adversity and COMT genotypes are associated with abnormal brain connectivity, structurally and functionally. Early identification of individuals at risk, assessment of brain abnormality, and cognitive interventions may help to prevent or limit negative outcomes.https://doi.org/10.1002/brb3.1858catechol‐O‐methyltransferasechildhood adversityfunctional connectivitygraph theorymorphometric similarity networkRRID: SCR_001847 |
| spellingShingle | Tian Tian Jia Li Guiling Zhang Jian Wang Dong Liu Changhua Wan Jicheng Fang Di Wu Yiran Zhou Wenzhen Zhu Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study Brain and Behavior catechol‐O‐methyltransferase childhood adversity functional connectivity graph theory morphometric similarity network RRID: SCR_001847 |
| title | Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study |
| title_full | Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study |
| title_fullStr | Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study |
| title_full_unstemmed | Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study |
| title_short | Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study |
| title_sort | effects of childhood trauma experience and comt val158met polymorphism on brain connectivity in a multimodal mri study |
| topic | catechol‐O‐methyltransferase childhood adversity functional connectivity graph theory morphometric similarity network RRID: SCR_001847 |
| url | https://doi.org/10.1002/brb3.1858 |
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