The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy

The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy

Mefenamic acid has been used as a non-steroidal anti-inflammatory drug for a long time. However, its practical use is quite limited due to a number of side effects on the intestinal organs. Conformational polymorphism provides mefenamic acid with unique properties regarding possible modifications ob...

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Bibliographic Details
Main Authors: Konstantin V. Belov, Luís A. E. Batista de Carvalho, Alexey A. Dyshin, Sergey V. Efimov, Ilya A. Khodov
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
supercritical fluid
fenamates
spatial structure
high-pressure NMR
Online Access:https://www.mdpi.com/1999-4923/14/11/2276

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