27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons

27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons

Abstract Background Accumulation of the α-synuclein (α-syn) protein is a hallmark of a group of brain disorders collectively known as synucleinopathies. The mechanisms responsible for α-syn accumulation are not well understood. Several studies suggest a link between synucleinopathies and the cholest...

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Bibliographic Details
Main Authors: Jared Schommer, Gurdeep Marwarha, Trevor Schommer, Travis Flick, Jonah Lund, Othman Ghribi
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Neuroscience
Subjects:
27-Hydroxycholesterol
Αlpha-synuclein
Liver X receptor
Parkinson’s disease
Dopaminergic neurons
Proteasomal dysfunction
Online Access:http://link.springer.com/article/10.1186/s12868-018-0420-5

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