Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic Mice
Diabetes is a serious disease that threatens human health worldwide. The study hypothesis is to investigate the novel trends that may aid in the prevention of diabetic complications. Camel milk was presented as traditional functional food, and Lactobacillus brevis KLDS1.0727 and KLDS1.0373 strains w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.943930/full |
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| author | Amro Abdelazez Amro Abdelazez Amro Abdelazez Garsa Alshehry Eman Algarni Huda Al Jumayi Heba Abdel-Motaal Heba Abdel-Motaal Xiang-Chen Meng |
| author_facet | Amro Abdelazez Amro Abdelazez Amro Abdelazez Garsa Alshehry Eman Algarni Huda Al Jumayi Heba Abdel-Motaal Heba Abdel-Motaal Xiang-Chen Meng |
| author_sort | Amro Abdelazez |
| collection | DOAJ |
| description | Diabetes is a serious disease that threatens human health worldwide. The study hypothesis is to investigate the novel trends that may aid in the prevention of diabetic complications. Camel milk was presented as traditional functional food, and Lactobacillus brevis KLDS1.0727 and KLDS1.0373 strains were shown to synthesize postbiotic Gamma-aminobutyric acid as a potential food additive, which can therapeutically intervene against hyperglycemia and hyperlipidemia in streptozotocin-induced C57BL/6J mice. During a four-week timeframe, body weight and postprandial blood glucose levels were monitored. Post-euthanasia, blood plasma was obtained to investigate hyperlipidemia, insulin concentrations, liver, and renal functions. The liver, pancreas, kidney, and spleen underwent histopathological examinations. The results demonstrated that KLDS1.0727 and KLDS1.0373 (LACS1, LACS2) and camel milk treatments all had a significant influence on hypoglycemic activity, as evidenced by reduced postprandial blood glucose levels. LACS1, LACS2, and camel milk therapy significantly reduced blood hypolipidemic, and some liver enzymes such as (alanine aminotransferase and aspartate transaminase) levels. Therefore, we recommend consuming camel milk regularly and expanding its use with fermented foods containing L. brevis, one of the probiotics capable of producing gamma-aminobutyric acid (GABA) as future food additives that can improve human health and reduce the prevalence of several diseases disorders. |
| first_indexed | 2024-04-13T13:53:54Z |
| format | Article |
| id | doaj.art-f60feb7f0b794529a14cb42f70006a13 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T13:53:54Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f60feb7f0b794529a14cb42f70006a132022-12-22T02:44:16ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-07-011310.3389/fmicb.2022.943930943930Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic MiceAmro Abdelazez0Amro Abdelazez1Amro Abdelazez2Garsa Alshehry3Eman Algarni4Huda Al Jumayi5Heba Abdel-Motaal6Heba Abdel-Motaal7Xiang-Chen Meng8Key Laboratory of Dairy Science, Ministry of Education, College of Food Sciences, Northeast Agricultural University, Harbin, ChinaFaculty of Agriculture and Forestry, Institute of Microbe and Host Health, Linyi University, Linyi, ChinaDepartment of Dairy Microbiology, Agriculture Research Centre, Animal Production Research Institute, Giza, EgyptDepartment of Food Science and Nutrition, College of Sciences, Taif University, Taif, Saudi ArabiaDepartment of Food Science and Nutrition, College of Sciences, Taif University, Taif, Saudi ArabiaDepartment of Food Science and Nutrition, College of Sciences, Taif University, Taif, Saudi ArabiaFaculty of Agriculture and Forestry, Institute of Microbe and Host Health, Linyi University, Linyi, ChinaDepartment of Microbiology, Agriculture Research Center, Soils, Water, Environment and Microbiology Research Institute, Giza, EgyptKey Laboratory of Dairy Science, Ministry of Education, College of Food Sciences, Northeast Agricultural University, Harbin, ChinaDiabetes is a serious disease that threatens human health worldwide. The study hypothesis is to investigate the novel trends that may aid in the prevention of diabetic complications. Camel milk was presented as traditional functional food, and Lactobacillus brevis KLDS1.0727 and KLDS1.0373 strains were shown to synthesize postbiotic Gamma-aminobutyric acid as a potential food additive, which can therapeutically intervene against hyperglycemia and hyperlipidemia in streptozotocin-induced C57BL/6J mice. During a four-week timeframe, body weight and postprandial blood glucose levels were monitored. Post-euthanasia, blood plasma was obtained to investigate hyperlipidemia, insulin concentrations, liver, and renal functions. The liver, pancreas, kidney, and spleen underwent histopathological examinations. The results demonstrated that KLDS1.0727 and KLDS1.0373 (LACS1, LACS2) and camel milk treatments all had a significant influence on hypoglycemic activity, as evidenced by reduced postprandial blood glucose levels. LACS1, LACS2, and camel milk therapy significantly reduced blood hypolipidemic, and some liver enzymes such as (alanine aminotransferase and aspartate transaminase) levels. Therefore, we recommend consuming camel milk regularly and expanding its use with fermented foods containing L. brevis, one of the probiotics capable of producing gamma-aminobutyric acid (GABA) as future food additives that can improve human health and reduce the prevalence of several diseases disorders.https://www.frontiersin.org/articles/10.3389/fmicb.2022.943930/fullpostbioticgamma-aminobutyric acidLactobacillus brevisdiabetes type 1camel milkC57BL/6 mice |
| spellingShingle | Amro Abdelazez Amro Abdelazez Amro Abdelazez Garsa Alshehry Eman Algarni Huda Al Jumayi Heba Abdel-Motaal Heba Abdel-Motaal Xiang-Chen Meng Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic Mice Frontiers in Microbiology postbiotic gamma-aminobutyric acid Lactobacillus brevis diabetes type 1 camel milk C57BL/6 mice |
| title | Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic Mice |
| title_full | Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic Mice |
| title_fullStr | Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic Mice |
| title_full_unstemmed | Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic Mice |
| title_short | Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced C57BL/6J Diabetic Mice |
| title_sort | postbiotic gamma aminobutyric acid and camel milk intervention as innovative trends against hyperglycemia and hyperlipidemia in streptozotocin induced c57bl 6j diabetic mice |
| topic | postbiotic gamma-aminobutyric acid Lactobacillus brevis diabetes type 1 camel milk C57BL/6 mice |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.943930/full |
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