Long-Term Consequences of COVID-19 Lockdown in Neovascular AMD Patients in Spain: Structural and Functional Outcomes after 1 Year of Standard Follow-Up and Treatment
Consequences of the COVID-19 pandemic on medical care have been extensively analyzed. Specifically, in ophthalmology practice, patients suffering age-related macular degeneration (AMD) represent one of the most affected subgroups. After reporting the acute consequences of treatment suspension in neo...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/5063 |
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| author | Daniela Rego-Lorca Alicia Valverde-Megías José Ignacio Fernández-Vigo Carlos Oribio-Quinto Antonio Murciano-Cespedosa Julia Sánchez-Quirós Juan Donate-López Julián García-Feijóo |
| author_facet | Daniela Rego-Lorca Alicia Valverde-Megías José Ignacio Fernández-Vigo Carlos Oribio-Quinto Antonio Murciano-Cespedosa Julia Sánchez-Quirós Juan Donate-López Julián García-Feijóo |
| author_sort | Daniela Rego-Lorca |
| collection | DOAJ |
| description | Consequences of the COVID-19 pandemic on medical care have been extensively analyzed. Specifically, in ophthalmology practice, patients suffering age-related macular degeneration (AMD) represent one of the most affected subgroups. After reporting the acute consequences of treatment suspension in neovascular AMD, we have now evaluated these same 242 patients (270 eyes) to assess if prior functional and anatomical situations can be restored after twelve months of regular follow-up and treatment. We compared data from visits before COVID-19 outbreak and the first visit after lockdown with data obtained in subsequent visits, until one year of follow-up was achieved. For each patient, rate of visual loss per year before COVID-19 pandemic, considered “natural history of treated AMD”, was calculated. This rate of visual loss significantly increased during the lockdown period and now, after twelve months of regular follow-up, is still higher than before COVID outbreak (3.1 vs. 1.6 ETDRS letters/year, <i>p</i> < 0.01). Percentage of OCT images showing active disease is now lower than before the lockdown period (51% vs. 65.3%, <i>p</i> = 0.0017). Although anatomic deterioration, regarding signs of active disease, can be apparently fully restored, our results suggest that functional consequences of temporary anti-VEGF treatment suspension are not entirely reversible after 12 months of treatment, as BCVA remains lower and visual loss rate is still higher than before the COVID-19 pandemic. |
| first_indexed | 2024-03-10T01:39:55Z |
| format | Article |
| id | doaj.art-f610e74a98a840d181e9eb0ee0d9c102 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:39:55Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f610e74a98a840d181e9eb0ee0d9c1022023-11-23T13:27:01ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011117506310.3390/jcm11175063Long-Term Consequences of COVID-19 Lockdown in Neovascular AMD Patients in Spain: Structural and Functional Outcomes after 1 Year of Standard Follow-Up and TreatmentDaniela Rego-Lorca0Alicia Valverde-Megías1José Ignacio Fernández-Vigo2Carlos Oribio-Quinto3Antonio Murciano-Cespedosa4Julia Sánchez-Quirós5Juan Donate-López6Julián García-Feijóo7Department of Ophthalmology, San Carlos Clinical Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, SpainDepartment of Ophthalmology, San Carlos Clinical Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, SpainDepartment of Ophthalmology, San Carlos Clinical Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, SpainDepartment of Ophthalmology, San Carlos Clinical Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, SpainDepartment of Biodiversity, Ecology & Evolution, Faculty of Biology, Complutense University, 28040 Madrid, SpainDepartment of Ophthalmology, San Carlos Clinical Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, SpainDepartment of Ophthalmology, San Carlos Clinical Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, SpainDepartment of Ophthalmology, San Carlos Clinical Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, SpainConsequences of the COVID-19 pandemic on medical care have been extensively analyzed. Specifically, in ophthalmology practice, patients suffering age-related macular degeneration (AMD) represent one of the most affected subgroups. After reporting the acute consequences of treatment suspension in neovascular AMD, we have now evaluated these same 242 patients (270 eyes) to assess if prior functional and anatomical situations can be restored after twelve months of regular follow-up and treatment. We compared data from visits before COVID-19 outbreak and the first visit after lockdown with data obtained in subsequent visits, until one year of follow-up was achieved. For each patient, rate of visual loss per year before COVID-19 pandemic, considered “natural history of treated AMD”, was calculated. This rate of visual loss significantly increased during the lockdown period and now, after twelve months of regular follow-up, is still higher than before COVID outbreak (3.1 vs. 1.6 ETDRS letters/year, <i>p</i> < 0.01). Percentage of OCT images showing active disease is now lower than before the lockdown period (51% vs. 65.3%, <i>p</i> = 0.0017). Although anatomic deterioration, regarding signs of active disease, can be apparently fully restored, our results suggest that functional consequences of temporary anti-VEGF treatment suspension are not entirely reversible after 12 months of treatment, as BCVA remains lower and visual loss rate is still higher than before the COVID-19 pandemic.https://www.mdpi.com/2077-0383/11/17/5063COVID-19pandemiclockdown effectsnAMDanti-VEGF |
| spellingShingle | Daniela Rego-Lorca Alicia Valverde-Megías José Ignacio Fernández-Vigo Carlos Oribio-Quinto Antonio Murciano-Cespedosa Julia Sánchez-Quirós Juan Donate-López Julián García-Feijóo Long-Term Consequences of COVID-19 Lockdown in Neovascular AMD Patients in Spain: Structural and Functional Outcomes after 1 Year of Standard Follow-Up and Treatment Journal of Clinical Medicine COVID-19 pandemic lockdown effects nAMD anti-VEGF |
| title | Long-Term Consequences of COVID-19 Lockdown in Neovascular AMD Patients in Spain: Structural and Functional Outcomes after 1 Year of Standard Follow-Up and Treatment |
| title_full | Long-Term Consequences of COVID-19 Lockdown in Neovascular AMD Patients in Spain: Structural and Functional Outcomes after 1 Year of Standard Follow-Up and Treatment |
| title_fullStr | Long-Term Consequences of COVID-19 Lockdown in Neovascular AMD Patients in Spain: Structural and Functional Outcomes after 1 Year of Standard Follow-Up and Treatment |
| title_full_unstemmed | Long-Term Consequences of COVID-19 Lockdown in Neovascular AMD Patients in Spain: Structural and Functional Outcomes after 1 Year of Standard Follow-Up and Treatment |
| title_short | Long-Term Consequences of COVID-19 Lockdown in Neovascular AMD Patients in Spain: Structural and Functional Outcomes after 1 Year of Standard Follow-Up and Treatment |
| title_sort | long term consequences of covid 19 lockdown in neovascular amd patients in spain structural and functional outcomes after 1 year of standard follow up and treatment |
| topic | COVID-19 pandemic lockdown effects nAMD anti-VEGF |
| url | https://www.mdpi.com/2077-0383/11/17/5063 |
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