Total Synthesis of the Four Stereoisomers of Cyclo(<span style="font-variant: small-caps">l</span>-Trp-<span style="font-variant: small-caps">l</span>-Arg) Raises Uncertainty of the Structures of the Natural Products and Invalidates Their Promising Antimicrobial Activities

Total Synthesis of the Four Stereoisomers of Cyclo(<span style="font-variant: small-caps">l</span>-Trp-<span style="font-variant: small-caps">l</span>-Arg) Raises Uncertainty of the Structures of the Natural Products and Invalidates Their Promising Antimicrobial Activities

New therapeutic options to combat the growing incidence of antimicrobial resistance are urgently needed. A 2015 publication reported the isolation and biological evaluation of two diketopiperazine natural products, cyclo(<span style="font-variant: small-caps;">l</span>-Trp-<...

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Bibliographic Details
Main Authors: Dan Chen, Daniel J. Park, Melissa M. Cadelis, Hana Douafer, Marie Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R. Copp
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
diketopiperazine
cyclo(Trp-Arg)
natural product
synthesis
structure revision
antimicrobial
Online Access:https://www.mdpi.com/1420-3049/27/18/5913

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