Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study
Objective Infection is a major cause of death in patients with SLE. This study aimed to explore the infection rate in patients with SLE receiving a low dose of intravenous cyclophosphamide (IV-CYC).Methods Clinical parameters of 1022 patients with SLE from 24 hospitals in China were collected. Patie...
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BMJ Publishing Group
2022-12-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/9/1/e000779.full |
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| author | Lei Zhang Xia Zhang Hong Zhu Zhanguo Li Jing He Yan Du Xuewu Zhang Jian Xu Fei Wang Jie Wu Qing Zhao Shuang Liu Miao Shao Miao Miao Xiaoying Zhang Xiaoping Zhang Jin Lin Zhibin Chen Shengyun Liu Xiao Wu Ru Li Lianjie Shi Hongjiang Liu Yao Chen Feng Yu Qingwen Wang Liyun Zhang Li Long Honglian Yu Yuan An Huifang Guo Lingyan Lei Yanjie Ding Rui Wu Yucui Li Huali Miao Ruiying Jiao Lixia Pang Xueming Yao Xiaofei Shi Luping Cui Fuai Lu Kangkai Luo Simeng Zhao Yongfu Wang Shulin Song Xiaoyuan Zhou Shumei Shi Ruiyun Yu Wenqiang Fan |
| author_facet | Lei Zhang Xia Zhang Hong Zhu Zhanguo Li Jing He Yan Du Xuewu Zhang Jian Xu Fei Wang Jie Wu Qing Zhao Shuang Liu Miao Shao Miao Miao Xiaoying Zhang Xiaoping Zhang Jin Lin Zhibin Chen Shengyun Liu Xiao Wu Ru Li Lianjie Shi Hongjiang Liu Yao Chen Feng Yu Qingwen Wang Liyun Zhang Li Long Honglian Yu Yuan An Huifang Guo Lingyan Lei Yanjie Ding Rui Wu Yucui Li Huali Miao Ruiying Jiao Lixia Pang Xueming Yao Xiaofei Shi Luping Cui Fuai Lu Kangkai Luo Simeng Zhao Yongfu Wang Shulin Song Xiaoyuan Zhou Shumei Shi Ruiyun Yu Wenqiang Fan |
| author_sort | Lei Zhang |
| collection | DOAJ |
| description | Objective Infection is a major cause of death in patients with SLE. This study aimed to explore the infection rate in patients with SLE receiving a low dose of intravenous cyclophosphamide (IV-CYC).Methods Clinical parameters of 1022 patients with SLE from 24 hospitals in China were collected. Patients were divided into the short-interval and lower-dose (SILD, 400 mg every 2 weeks) IV-CYC group and the high-dose (HD, 500 mg/m2 of body surface area every month) IV-CYC group. The clinical data and infection rate between the two groups were compared.Results Compared with HD IV-CYC, the infection rate of the SILD IV-CYC group was significantly lower (13.04% vs 22.27%, p=0.001). Respiratory tract infection (10.28% vs 15.23%, p=0.046) and skin/soft tissue infection (1.78% vs 4.3%, p=0.040) were significantly decreased in the SILD IV-CYC group. Moreover, infections occurred most likely in patients with SLE with leucopenia (OR 2.266, 95% CI 1.322 to 3.887, p=0.003), pulmonary arterial hypertension (OR 2.756, 95% CI 1.249 to 6.080, p=0.012) and >15 mg/day of glucocorticoid (OR 2.220, 95% CI 1.097 to 4.489, p=0.027).Conclusions SILD IV-CYC showed a lower frequency of infection events than high-dose IV-CYC in patients with SLE. |
| first_indexed | 2024-03-13T01:48:06Z |
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| publishDate | 2022-12-01 |
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| spelling | doaj.art-f615c3388764433e9ae69f653a8937b12023-07-03T06:00:07ZengBMJ Publishing GroupLupus Science and Medicine2053-87902022-12-019110.1136/lupus-2022-000779Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world studyLei Zhang0Xia Zhang1Hong Zhu2Zhanguo Li3Jing He4Yan Du5Xuewu Zhang6Jian Xu7Fei Wang8Jie Wu9Qing Zhao10Shuang Liu11Miao Shao12Miao Miao13Xiaoying Zhang14Xiaoping Zhang15Jin Lin16Zhibin Chen17Shengyun Liu18Xiao Wu19Ru Li20Lianjie Shi21Hongjiang Liu22Yao Chen23Feng Yu24Qingwen Wang25Liyun Zhang26Li Long27Honglian Yu28Yuan An29Huifang Guo30Lingyan Lei31Yanjie Ding32Rui Wu33Yucui Li34Huali Miao35Ruiying Jiao36Lixia Pang37Xueming Yao38Xiaofei Shi39Luping Cui40Fuai Lu41Kangkai Luo42Simeng Zhao43Yongfu Wang44Shulin Song45Xiaoyuan Zhou46Shumei Shi47Ruiyun Yu48Wenqiang Fan49Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Rheumatology and Immunology, Peking University People`s Hospital, Beijing, ChinaWest China School of Nursing, Sichuan University/Nursing Department, Sichuan University West China Hospital, Chengdu, Sichuan, ChinaDepartment of Rheumatology and Immunology, Peking University People`s Hospital, Beijing, China1 Department of Rheumatology and Immunology, Peking University People`s Hospital, Beijing, ChinaDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Rheumatology, Peking University People’s Hospital, Beijing, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, ChinaDepartment of Anesthesiology, Xuanwu Hospital Capital Medical University, Beijing, ChinaDepartment of Cardiovascular Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Rheumatology and Immunology, Peking University People`s Hospital, Beijing, ChinaAffliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Rheumatology and Immunology, Peking University People`s Hospital, Beijing, ChinaDepartment of Nephrology and Rheumatology, The PLA 960 Hospital, Jinan, Shandong, ChinaDepartment of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, The Affiliated Yueqing Hospital of Wenzhou Medical University, Yueqing, Zhejiang, ChinaFirst Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Biostatistics, Harvard University T H Chan School of Public Health, Boston, MA, USADepartment of Rheumatology and Immunology, Peking University People`s Hospital, Beijing, ChinaDepartment of Rheumatology and Immunology, Peking University International Hospital, Beijing, ChinaDepartment of Rheumatology and Immunology, The First People`s Hospital of Yichang, Yichang, Hubei, ChinaDepartment of Hematology and Rheumatology, Wu zhong People`s Hospital, Wuzhong, Ningxia, ChinaRenal Division, Department of Medicine, Peking University First Hospital, Beijing, ChinaDepartment of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Rheumatology and Immunology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, ChinaDepartment of Rheumatology and Immunology, Sichuan Provincial People`s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Rheumatology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, ChinaDepartment of Rheumatology and Immunology, Peking University People`s Hospital, Beijing, ChinaDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, Henan, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Rheumatology and Immunology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, ChinaDepartment of Rheumatology and Immunology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, ChinaDepartment of Rheumatology and Immunology, Hulunbuir People`s Hospital, Hulunbuir, Inner Mongolia, ChinaDepartment of Rheumatology and Immunology, Hulunbuir People`s Hospital, Hulunbuir, Inner Mongolia, ChinaDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, ChinaDepartment of Rheumatology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, ChinaDepartment of Rheumatology and Immunology, The First People`s Hospital of Yichang, Yichang, Hubei, ChinaDepartment of Nephrology and Rheumatology, Zunyi Medical University Hospital, Zunyi, Guizhou, ChinaDepartment of Nephrology and Rheumatology, The PLA 960 Hospital, Jinan, Shandong, ChinaDepartment of Rheumatology and Immunology, Xinxiang Central Hospital, Xinxiang, Henan, ChinaDepartment of Rheumatology and Immunology, Xinxiang Central Hospital, Xinxiang, Henan, ChinaObjective Infection is a major cause of death in patients with SLE. This study aimed to explore the infection rate in patients with SLE receiving a low dose of intravenous cyclophosphamide (IV-CYC).Methods Clinical parameters of 1022 patients with SLE from 24 hospitals in China were collected. Patients were divided into the short-interval and lower-dose (SILD, 400 mg every 2 weeks) IV-CYC group and the high-dose (HD, 500 mg/m2 of body surface area every month) IV-CYC group. The clinical data and infection rate between the two groups were compared.Results Compared with HD IV-CYC, the infection rate of the SILD IV-CYC group was significantly lower (13.04% vs 22.27%, p=0.001). Respiratory tract infection (10.28% vs 15.23%, p=0.046) and skin/soft tissue infection (1.78% vs 4.3%, p=0.040) were significantly decreased in the SILD IV-CYC group. Moreover, infections occurred most likely in patients with SLE with leucopenia (OR 2.266, 95% CI 1.322 to 3.887, p=0.003), pulmonary arterial hypertension (OR 2.756, 95% CI 1.249 to 6.080, p=0.012) and >15 mg/day of glucocorticoid (OR 2.220, 95% CI 1.097 to 4.489, p=0.027).Conclusions SILD IV-CYC showed a lower frequency of infection events than high-dose IV-CYC in patients with SLE.https://lupus.bmj.com/content/9/1/e000779.full |
| spellingShingle | Lei Zhang Xia Zhang Hong Zhu Zhanguo Li Jing He Yan Du Xuewu Zhang Jian Xu Fei Wang Jie Wu Qing Zhao Shuang Liu Miao Shao Miao Miao Xiaoying Zhang Xiaoping Zhang Jin Lin Zhibin Chen Shengyun Liu Xiao Wu Ru Li Lianjie Shi Hongjiang Liu Yao Chen Feng Yu Qingwen Wang Liyun Zhang Li Long Honglian Yu Yuan An Huifang Guo Lingyan Lei Yanjie Ding Rui Wu Yucui Li Huali Miao Ruiying Jiao Lixia Pang Xueming Yao Xiaofei Shi Luping Cui Fuai Lu Kangkai Luo Simeng Zhao Yongfu Wang Shulin Song Xiaoyuan Zhou Shumei Shi Ruiyun Yu Wenqiang Fan Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study Lupus Science and Medicine |
| title | Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study |
| title_full | Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study |
| title_fullStr | Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study |
| title_full_unstemmed | Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study |
| title_short | Comparison of short interval and low dose (SILD) with high dose of cyclophosphamide in the susceptibility to infection in SLE: a multicentrereal-world study |
| title_sort | comparison of short interval and low dose sild with high dose of cyclophosphamide in the susceptibility to infection in sle a multicentrereal world study |
| url | https://lupus.bmj.com/content/9/1/e000779.full |
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