Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies
Abstract Background Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-03-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-019-3892-8 |
| _version_ | 1818319718884311040 |
|---|---|
| author | Animut Alebel Amsalu Taye Wondemagegn Cheru Tesema Getiye Dejenu Kibret Fasil Wagnew Pammla Petrucka Amit Arora Amare Demsie Ayele Mulunesh Alemayehu Setegn Eshetie |
| author_facet | Animut Alebel Amsalu Taye Wondemagegn Cheru Tesema Getiye Dejenu Kibret Fasil Wagnew Pammla Petrucka Amit Arora Amare Demsie Ayele Mulunesh Alemayehu Setegn Eshetie |
| author_sort | Animut Alebel |
| collection | DOAJ |
| description | Abstract Background Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta-analysis estimates the overall prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa. Methods Four international databases (PubMed, Google Scholar, Science Direct and Cochrane Library) were systematically searched. We included all observational studies reporting the prevalence of DM among TB patients in Sub-Saharan Africa. All necessary data for this review were extracted using a standardized data extraction format by two authors (CT and AA1). STATA Version 14 statistical software was employed to conduct meta-analysis. The Cochrane Q test statistics and I 2 test were used to assess the heterogeneity of the studies. Finally, a random effects meta-analysis model was computed to estimate the pooled prevalence of diabetes mellitus in TB patients. Besides, subgroup analysis was done based on different factors. Results In the meta-analysis, sixteen studies fulfilled the inclusion criteria and were included. The findings of these 16 studies revealed that the pooled prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was 9.0% (95% CI: 6.0, 12.0%). The highest prevalence of diabetes mellitus among tuberculosis patients was found in Nigeria (15%), followed by Tanzania (11%), and then Ethiopia (10%). Besides, the prevalence of diabetes mellitus among HIV infected TB patients was (8.9%) which is slightly higher than HIV uninfected (7.7%) TB patients. Conclusion Diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was significantly high. Moreover, this study found that there was a high prevalence of DM among HIV infected than uninfected TB patients. It is strongly recommended to screen for DM among TB patients and special emphasis should be given for early screening of DM among TB/HIV co-infected patients. |
| first_indexed | 2024-12-13T10:13:34Z |
| format | Article |
| id | doaj.art-f6168602a92b4b77b9a1a26fb94c2d9a |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T10:13:34Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-f6168602a92b4b77b9a1a26fb94c2d9a2022-12-21T23:51:23ZengBMCBMC Infectious Diseases1471-23342019-03-0119111010.1186/s12879-019-3892-8Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studiesAnimut Alebel0Amsalu Taye Wondemagegn1Cheru Tesema2Getiye Dejenu Kibret3Fasil Wagnew4Pammla Petrucka5Amit Arora6Amare Demsie Ayele7Mulunesh Alemayehu8Setegn Eshetie9College of Health Sciences, Debre Markos UniversityCollege of Health Sciences, Debre Markos UniversityCollege of Health Sciences, Debre Markos UniversityCollege of Health Sciences, Debre Markos UniversityCollege of Health Sciences, Debre Markos UniversityCollege of Nursing, University of SaskatchewanSchool of Science and Health, Western Sydney UniversityCollege of Medicine and Health Sciences, University of GondarCollege of Health Sciences, Debre Markos UniversityCollege of Medicine and Health Sciences, University of GondarAbstract Background Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta-analysis estimates the overall prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa. Methods Four international databases (PubMed, Google Scholar, Science Direct and Cochrane Library) were systematically searched. We included all observational studies reporting the prevalence of DM among TB patients in Sub-Saharan Africa. All necessary data for this review were extracted using a standardized data extraction format by two authors (CT and AA1). STATA Version 14 statistical software was employed to conduct meta-analysis. The Cochrane Q test statistics and I 2 test were used to assess the heterogeneity of the studies. Finally, a random effects meta-analysis model was computed to estimate the pooled prevalence of diabetes mellitus in TB patients. Besides, subgroup analysis was done based on different factors. Results In the meta-analysis, sixteen studies fulfilled the inclusion criteria and were included. The findings of these 16 studies revealed that the pooled prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was 9.0% (95% CI: 6.0, 12.0%). The highest prevalence of diabetes mellitus among tuberculosis patients was found in Nigeria (15%), followed by Tanzania (11%), and then Ethiopia (10%). Besides, the prevalence of diabetes mellitus among HIV infected TB patients was (8.9%) which is slightly higher than HIV uninfected (7.7%) TB patients. Conclusion Diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was significantly high. Moreover, this study found that there was a high prevalence of DM among HIV infected than uninfected TB patients. It is strongly recommended to screen for DM among TB patients and special emphasis should be given for early screening of DM among TB/HIV co-infected patients.http://link.springer.com/article/10.1186/s12879-019-3892-8Type1/type 2 diabetes mellitusTuberculosisSub-Saharan Africa |
| spellingShingle | Animut Alebel Amsalu Taye Wondemagegn Cheru Tesema Getiye Dejenu Kibret Fasil Wagnew Pammla Petrucka Amit Arora Amare Demsie Ayele Mulunesh Alemayehu Setegn Eshetie Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies BMC Infectious Diseases Type1/type 2 diabetes mellitus Tuberculosis Sub-Saharan Africa |
| title | Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies |
| title_full | Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies |
| title_fullStr | Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies |
| title_short | Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies |
| title_sort | prevalence of diabetes mellitus among tuberculosis patients in sub saharan africa a systematic review and meta analysis of observational studies |
| topic | Type1/type 2 diabetes mellitus Tuberculosis Sub-Saharan Africa |
| url | http://link.springer.com/article/10.1186/s12879-019-3892-8 |
| work_keys_str_mv | AT animutalebel prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT amsalutayewondemagegn prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT cherutesema prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT getiyedejenukibret prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT fasilwagnew prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT pammlapetrucka prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT amitarora prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT amaredemsieayele prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT muluneshalemayehu prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies AT setegneshetie prevalenceofdiabetesmellitusamongtuberculosispatientsinsubsaharanafricaasystematicreviewandmetaanalysisofobservationalstudies |