Cancer Treatment; New Strategies/New Hopes

Beginning in the early 2000s and based on the better understanding of the biology of cancer, new drugs have been developed that target specific molecular pathway in malignant cells. There has been a significant shift from the development of classic cytotoxic agents toward targeted therapies. Dose li...

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Bibliographic Details
Main Authors: Ebrahim Salehifar, Maria Tavakkoli-Ardakani
Format: Article
Language:English
Published: Research Center for Rational Use of Drugs (RCRUD) 2020-03-01
Series:Journal of Pharmaceutical Care
Subjects:
Online Access:https://jpc.tums.ac.ir/index.php/jpc/article/view/332
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author Ebrahim Salehifar
Maria Tavakkoli-Ardakani
author_facet Ebrahim Salehifar
Maria Tavakkoli-Ardakani
author_sort Ebrahim Salehifar
collection DOAJ
description Beginning in the early 2000s and based on the better understanding of the biology of cancer, new drugs have been developed that target specific molecular pathway in malignant cells. There has been a significant shift from the development of classic cytotoxic agents toward targeted therapies. Dose limiting toxicities of target therapies are often different. These agents have unique mechanism of action and are very specific for one or several key cellular biologic pathways. Introduction of these agents was associated with a significant progress in the management of some cancers. A good example is use of tyrosine kinase inhibitor (TKIs) for the treatment of chronic myeloid leukemia. Imatinib was the first one and several other TKIs such as dasatinib, nilotinib, bosutinib and ponatinib have been developed.
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spelling doaj.art-f618137b6a1447dcb79b7f8ef1b78b532022-12-21T19:14:06ZengResearch Center for Rational Use of Drugs (RCRUD)Journal of Pharmaceutical Care2322-46302322-45092020-03-018110.18502/jpc.v8i1.2739332Cancer Treatment; New Strategies/New HopesEbrahim Salehifar0Maria Tavakkoli-Ardakani1Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranBeginning in the early 2000s and based on the better understanding of the biology of cancer, new drugs have been developed that target specific molecular pathway in malignant cells. There has been a significant shift from the development of classic cytotoxic agents toward targeted therapies. Dose limiting toxicities of target therapies are often different. These agents have unique mechanism of action and are very specific for one or several key cellular biologic pathways. Introduction of these agents was associated with a significant progress in the management of some cancers. A good example is use of tyrosine kinase inhibitor (TKIs) for the treatment of chronic myeloid leukemia. Imatinib was the first one and several other TKIs such as dasatinib, nilotinib, bosutinib and ponatinib have been developed.https://jpc.tums.ac.ir/index.php/jpc/article/view/332NoKeywords
spellingShingle Ebrahim Salehifar
Maria Tavakkoli-Ardakani
Cancer Treatment; New Strategies/New Hopes
Journal of Pharmaceutical Care
No
Keywords
title Cancer Treatment; New Strategies/New Hopes
title_full Cancer Treatment; New Strategies/New Hopes
title_fullStr Cancer Treatment; New Strategies/New Hopes
title_full_unstemmed Cancer Treatment; New Strategies/New Hopes
title_short Cancer Treatment; New Strategies/New Hopes
title_sort cancer treatment new strategies new hopes
topic No
Keywords
url https://jpc.tums.ac.ir/index.php/jpc/article/view/332
work_keys_str_mv AT ebrahimsalehifar cancertreatmentnewstrategiesnewhopes
AT mariatavakkoliardakani cancertreatmentnewstrategiesnewhopes