Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022
Since May 2022, mpox has been identified in 108 countries without endemic disease; most cases have been in gay, bisexual, or other men who have sex with men. To determine number of missed cases, we conducted 2 studies during June–September 2022: a prospective serologic survey detecting orthopoxviru...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2023-11-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/29/11/23-0940_article |
| _version_ | 1827785930699702272 |
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| author | Faisal S. Minhaj Vijay Singh Stephanie E. Cohen Michael Townsend Hyman Scott John Szumowski C. Bradley Hare Pallavi Upadhyay Jairus Reddy Barbara Alexander Nicolle Baird Terese Navarra Lalita Priyamvada Nhien Wynn William C. Carson Solomon Odafe Sarah Anne J. Guagliardo Emily Sims Agam K. Rao Panayampalli S. Satheshkumar Paul J. Weidle Christina L. Hutson |
| author_facet | Faisal S. Minhaj Vijay Singh Stephanie E. Cohen Michael Townsend Hyman Scott John Szumowski C. Bradley Hare Pallavi Upadhyay Jairus Reddy Barbara Alexander Nicolle Baird Terese Navarra Lalita Priyamvada Nhien Wynn William C. Carson Solomon Odafe Sarah Anne J. Guagliardo Emily Sims Agam K. Rao Panayampalli S. Satheshkumar Paul J. Weidle Christina L. Hutson |
| author_sort | Faisal S. Minhaj |
| collection | DOAJ |
| description |
Since May 2022, mpox has been identified in 108 countries without endemic disease; most cases have been in gay, bisexual, or other men who have sex with men. To determine number of missed cases, we conducted 2 studies during June–September 2022: a prospective serologic survey detecting orthopoxvirus antibodies among men who have sex with men in San Francisco, California, and a retrospective monkeypox virus PCR testing of swab specimens submitted for other infectious disease testing among all patients across the United States. The serosurvey of 225 participants (median age 34 years) detected 18 (8.0%) who were orthopoxvirus IgG positive and 3 (1.3%) who were also orthopoxvirus IgM positive. The retrospective PCR study of 1,196 patients (median age 30 years; 54.8% male) detected 67 (5.6%) specimens positive for monkeypox virus. There are likely few undiagnosed cases of mpox in regions where sexual healthcare is accessible and patient and clinician awareness about mpox is increased.
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| first_indexed | 2024-03-11T16:25:39Z |
| format | Article |
| id | doaj.art-f61855961cfc4df0adcffba27044933e |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-03-11T16:25:39Z |
| publishDate | 2023-11-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-f61855961cfc4df0adcffba27044933e2023-10-24T12:17:43ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-11-0129112307231410.3201/eid2911.230940Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022Faisal S. MinhajVijay SinghStephanie E. CohenMichael TownsendHyman ScottJohn SzumowskiC. Bradley HarePallavi UpadhyayJairus ReddyBarbara AlexanderNicolle BairdTerese NavarraLalita PriyamvadaNhien WynnWilliam C. CarsonSolomon OdafeSarah Anne J. GuagliardoEmily SimsAgam K. RaoPanayampalli S. SatheshkumarPaul J. WeidleChristina L. Hutson Since May 2022, mpox has been identified in 108 countries without endemic disease; most cases have been in gay, bisexual, or other men who have sex with men. To determine number of missed cases, we conducted 2 studies during June–September 2022: a prospective serologic survey detecting orthopoxvirus antibodies among men who have sex with men in San Francisco, California, and a retrospective monkeypox virus PCR testing of swab specimens submitted for other infectious disease testing among all patients across the United States. The serosurvey of 225 participants (median age 34 years) detected 18 (8.0%) who were orthopoxvirus IgG positive and 3 (1.3%) who were also orthopoxvirus IgM positive. The retrospective PCR study of 1,196 patients (median age 30 years; 54.8% male) detected 67 (5.6%) specimens positive for monkeypox virus. There are likely few undiagnosed cases of mpox in regions where sexual healthcare is accessible and patient and clinician awareness about mpox is increased. https://wwwnc.cdc.gov/eid/article/29/11/23-0940_articleMonkeypox virusMpoxorthopoxvirusIgMPCRundiagnosed |
| spellingShingle | Faisal S. Minhaj Vijay Singh Stephanie E. Cohen Michael Townsend Hyman Scott John Szumowski C. Bradley Hare Pallavi Upadhyay Jairus Reddy Barbara Alexander Nicolle Baird Terese Navarra Lalita Priyamvada Nhien Wynn William C. Carson Solomon Odafe Sarah Anne J. Guagliardo Emily Sims Agam K. Rao Panayampalli S. Satheshkumar Paul J. Weidle Christina L. Hutson Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022 Emerging Infectious Diseases Monkeypox virus Mpox orthopoxvirus IgM PCR undiagnosed |
| title | Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022 |
| title_full | Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022 |
| title_fullStr | Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022 |
| title_full_unstemmed | Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022 |
| title_short | Prevalence of Undiagnosed Monkeypox Virus Infections during Global Mpox Outbreak, United States, June–September 2022 |
| title_sort | prevalence of undiagnosed monkeypox virus infections during global mpox outbreak united states june september 2022 |
| topic | Monkeypox virus Mpox orthopoxvirus IgM PCR undiagnosed |
| url | https://wwwnc.cdc.gov/eid/article/29/11/23-0940_article |
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