Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved]
In selecting drug target candidates for pharmaceutical research, the linkage to disease and the tractability of the target are two important factors that can ultimately determine the drug efficacy. Several existing resources can provide gene-disease associations, but determining whether such a list...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2019-05-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-233/v2 |
| _version_ | 1818039462815334400 |
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| author | Yi-An Chen Erika Yogo Naoko Kurihara Tomoshige Ohno Chihiro Higuchi Masatomo Rokushima Kenji Mizuguchi |
| author_facet | Yi-An Chen Erika Yogo Naoko Kurihara Tomoshige Ohno Chihiro Higuchi Masatomo Rokushima Kenji Mizuguchi |
| author_sort | Yi-An Chen |
| collection | DOAJ |
| description | In selecting drug target candidates for pharmaceutical research, the linkage to disease and the tractability of the target are two important factors that can ultimately determine the drug efficacy. Several existing resources can provide gene-disease associations, but determining whether such a list of genes are attractive drug targets often requires further information gathering and analysis. In addition, few resources provide the information required to evaluate the tractability of a target. To address these issues, we have updated TargetMine, a data warehouse for assisting target prioritization, by integrating new data sources for gene-disease associations and enhancing functionalities for target assessment. As a data mining platform that integrates a variety of data sources, including protein structures and chemical compounds, TargetMine now offers a powerful and flexible interface for constructing queries to check genetic evidence, tractability and other relevant features for the candidate genes. We demonstrate these features by using several specific examples. |
| first_indexed | 2024-12-10T07:59:01Z |
| format | Article |
| id | doaj.art-f618b3fab7cc47e3b9e32110116856e6 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-10T07:59:01Z |
| publishDate | 2019-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-f618b3fab7cc47e3b9e32110116856e62022-12-22T01:56:49ZengF1000 Research LtdF1000Research2046-14022019-05-01810.12688/f1000research.18214.221287Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved]Yi-An Chen0Erika Yogo1Naoko Kurihara2Tomoshige Ohno3Chihiro Higuchi4Masatomo Rokushima5Kenji Mizuguchi6National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, 5670085, JapanShionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., Toyonaka, Osaka, 5610825, JapanShionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., Toyonaka, Osaka, 5610825, JapanShionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., Toyonaka, Osaka, 5610825, JapanNational Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, 5670085, JapanShionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., Toyonaka, Osaka, 5610825, JapanNational Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, 5670085, JapanIn selecting drug target candidates for pharmaceutical research, the linkage to disease and the tractability of the target are two important factors that can ultimately determine the drug efficacy. Several existing resources can provide gene-disease associations, but determining whether such a list of genes are attractive drug targets often requires further information gathering and analysis. In addition, few resources provide the information required to evaluate the tractability of a target. To address these issues, we have updated TargetMine, a data warehouse for assisting target prioritization, by integrating new data sources for gene-disease associations and enhancing functionalities for target assessment. As a data mining platform that integrates a variety of data sources, including protein structures and chemical compounds, TargetMine now offers a powerful and flexible interface for constructing queries to check genetic evidence, tractability and other relevant features for the candidate genes. We demonstrate these features by using several specific examples.https://f1000research.com/articles/8-233/v2 |
| spellingShingle | Yi-An Chen Erika Yogo Naoko Kurihara Tomoshige Ohno Chihiro Higuchi Masatomo Rokushima Kenji Mizuguchi Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved] F1000Research |
| title | Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved] |
| title_full | Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved] |
| title_fullStr | Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved] |
| title_full_unstemmed | Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved] |
| title_short | Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved] |
| title_sort | assessing drug target suitability using targetmine version 2 peer review 2 approved |
| url | https://f1000research.com/articles/8-233/v2 |
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