Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1
VSA-1 is a semisynthetic saponin adjuvant prepared from naturally occurring Momordica saponin and capable of stimulating antigen-specific humoral and cellular immune responses. Its immunostimulating activity in enhancing the immune responses induced by the clinical glycoconjugate pneumococcal vaccin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1079047/full |
| _version_ | 1811188184368807936 |
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| author | Hyunjung Kim Jigui Yu Di Bai Moon H. Nahm Moon H. Nahm Pengfei Wang |
| author_facet | Hyunjung Kim Jigui Yu Di Bai Moon H. Nahm Moon H. Nahm Pengfei Wang |
| author_sort | Hyunjung Kim |
| collection | DOAJ |
| description | VSA-1 is a semisynthetic saponin adjuvant prepared from naturally occurring Momordica saponin and capable of stimulating antigen-specific humoral and cellular immune responses. Its immunostimulating activity in enhancing the immune responses induced by the clinical glycoconjugate pneumococcal vaccine PCV13 is compared with QS-21 in female BALB/c mice. Both VSA-1 and QS-21 boosted IgG and opsonic antibodies titers against seven selected serotypes, including serotypes 3, 14, and 19A that are involved in most PCV13 breakthroughs. Since VSA-1 is much more accessible and of lower toxicity than QS-21, it can be a practical saponin immunostimulant to be included in a new glycoconjugate pneumococcal vaccine formulation. |
| first_indexed | 2024-04-11T14:16:19Z |
| format | Article |
| id | doaj.art-f61a608f3df548149073c2bf8fb60b95 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T14:16:19Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f61a608f3df548149073c2bf8fb60b952022-12-22T04:19:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10790471079047Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1Hyunjung Kim0Jigui Yu1Di Bai2Moon H. Nahm3Moon H. Nahm4Pengfei Wang5Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesWorld Health Organization (WHO) Pneumococcal Serology Reference Laboratory, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL, United StatesVSA-1 is a semisynthetic saponin adjuvant prepared from naturally occurring Momordica saponin and capable of stimulating antigen-specific humoral and cellular immune responses. Its immunostimulating activity in enhancing the immune responses induced by the clinical glycoconjugate pneumococcal vaccine PCV13 is compared with QS-21 in female BALB/c mice. Both VSA-1 and QS-21 boosted IgG and opsonic antibodies titers against seven selected serotypes, including serotypes 3, 14, and 19A that are involved in most PCV13 breakthroughs. Since VSA-1 is much more accessible and of lower toxicity than QS-21, it can be a practical saponin immunostimulant to be included in a new glycoconjugate pneumococcal vaccine formulation.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1079047/fullMomordica saponinadjuvantimmunostimulantpneumococcal vaccineVSA-1 |
| spellingShingle | Hyunjung Kim Jigui Yu Di Bai Moon H. Nahm Moon H. Nahm Pengfei Wang Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1 Frontiers in Immunology Momordica saponin adjuvant immunostimulant pneumococcal vaccine VSA-1 |
| title | Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1 |
| title_full | Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1 |
| title_fullStr | Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1 |
| title_full_unstemmed | Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1 |
| title_short | Potentiating pneumococcal glycoconjugate vaccine PCV13 with saponin adjuvant VSA-1 |
| title_sort | potentiating pneumococcal glycoconjugate vaccine pcv13 with saponin adjuvant vsa 1 |
| topic | Momordica saponin adjuvant immunostimulant pneumococcal vaccine VSA-1 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1079047/full |
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