Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic‐Chemotherapy of Orthotopic Bladder Cancer
Abstract Photochemical internalization (PCI) is a promising intervention using photodynamic therapy (PDT) to enhance the activity of chemotherapeutic drugs. However, current bladder cancer treatments involve high‐dose chemotherapy and high‐irradiance PDT which cause debilitating side effects. Moreov...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202200731 |
| _version_ | 1828318312857075712 |
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| author | Bowen Sun Juwita Norasmara Bte Rahmat Han Joon Kim Ratha Mahendran Kesavan Esuvaranathan Edmund Chiong John S. Ho Koon Gee Neoh Yong Zhang |
| author_facet | Bowen Sun Juwita Norasmara Bte Rahmat Han Joon Kim Ratha Mahendran Kesavan Esuvaranathan Edmund Chiong John S. Ho Koon Gee Neoh Yong Zhang |
| author_sort | Bowen Sun |
| collection | DOAJ |
| description | Abstract Photochemical internalization (PCI) is a promising intervention using photodynamic therapy (PDT) to enhance the activity of chemotherapeutic drugs. However, current bladder cancer treatments involve high‐dose chemotherapy and high‐irradiance PDT which cause debilitating side effects. Moreover, low penetration of light and drugs in target tissues and cumbersome light delivery procedures hinder the clinical utility of PDT and chemotherapy combination for PCI. To circumvent these challenges, a photodynamic‐chemotherapy approach is developed comprising tumor‐targeting glycosylated nanocarriers, coloaded with chlorin e6 (Ce6) and gemcitabine elaidate (GemE), and a miniaturized implantable wirelessly powered light‐emitting diode (LED) as a light source. The device successfully delivers four weekly light doses to the bladder while the nanocarrier promoted the specific accumulation of drugs in tumors. This approach facilitates the combination of low‐irradiance PDT (1 mW cm−2) and low‐dose chemotherapy (≈1500× lower than clinical dose) which significantly cures and controls orthotopic disease burden (90% treated vs control, 35%) in mice, demonstrating a potential new bladder cancer treatment option. |
| first_indexed | 2024-04-13T17:40:11Z |
| format | Article |
| id | doaj.art-f61db4600e4545e49928e1e12f635616 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-13T17:40:11Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-f61db4600e4545e49928e1e12f6356162022-12-22T02:37:13ZengWileyAdvanced Science2198-38442022-05-01916n/an/a10.1002/advs.202200731Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic‐Chemotherapy of Orthotopic Bladder CancerBowen Sun0Juwita Norasmara Bte Rahmat1Han Joon Kim2Ratha Mahendran3Kesavan Esuvaranathan4Edmund Chiong5John S. Ho6Koon Gee Neoh7Yong Zhang8Department of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore Singapore 117585 SingaporeDepartment of Biomedical Engineering College of Design and Engineering National University of Singapore Singapore 117583 SingaporeDepartment of Electrical and Computer Engineering College of Design and Engineering National University of Singapore Singapore 117583 SingaporeDepartment of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore 119228 SingaporeDepartment of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore 119228 SingaporeDepartment of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore 119228 SingaporeDepartment of Electrical and Computer Engineering College of Design and Engineering National University of Singapore Singapore 117583 SingaporeDepartment of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore Singapore 117585 SingaporeDepartment of Biomedical Engineering College of Design and Engineering National University of Singapore Singapore 117583 SingaporeAbstract Photochemical internalization (PCI) is a promising intervention using photodynamic therapy (PDT) to enhance the activity of chemotherapeutic drugs. However, current bladder cancer treatments involve high‐dose chemotherapy and high‐irradiance PDT which cause debilitating side effects. Moreover, low penetration of light and drugs in target tissues and cumbersome light delivery procedures hinder the clinical utility of PDT and chemotherapy combination for PCI. To circumvent these challenges, a photodynamic‐chemotherapy approach is developed comprising tumor‐targeting glycosylated nanocarriers, coloaded with chlorin e6 (Ce6) and gemcitabine elaidate (GemE), and a miniaturized implantable wirelessly powered light‐emitting diode (LED) as a light source. The device successfully delivers four weekly light doses to the bladder while the nanocarrier promoted the specific accumulation of drugs in tumors. This approach facilitates the combination of low‐irradiance PDT (1 mW cm−2) and low‐dose chemotherapy (≈1500× lower than clinical dose) which significantly cures and controls orthotopic disease burden (90% treated vs control, 35%) in mice, demonstrating a potential new bladder cancer treatment option.https://doi.org/10.1002/advs.202200731bladder cancerphotodynamic therapytargeted drug deliverywireless photonics |
| spellingShingle | Bowen Sun Juwita Norasmara Bte Rahmat Han Joon Kim Ratha Mahendran Kesavan Esuvaranathan Edmund Chiong John S. Ho Koon Gee Neoh Yong Zhang Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic‐Chemotherapy of Orthotopic Bladder Cancer Advanced Science bladder cancer photodynamic therapy targeted drug delivery wireless photonics |
| title | Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic‐Chemotherapy of Orthotopic Bladder Cancer |
| title_full | Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic‐Chemotherapy of Orthotopic Bladder Cancer |
| title_fullStr | Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic‐Chemotherapy of Orthotopic Bladder Cancer |
| title_full_unstemmed | Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic‐Chemotherapy of Orthotopic Bladder Cancer |
| title_short | Wirelessly Activated Nanotherapeutics for In Vivo Programmable Photodynamic‐Chemotherapy of Orthotopic Bladder Cancer |
| title_sort | wirelessly activated nanotherapeutics for in vivo programmable photodynamic chemotherapy of orthotopic bladder cancer |
| topic | bladder cancer photodynamic therapy targeted drug delivery wireless photonics |
| url | https://doi.org/10.1002/advs.202200731 |
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