A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer
A high-fat diet (HFD) and obesity are risk factors for many diseases including breast cancer. This is particularly important with close to 40% of the current adult population being overweight or obese. Previous studies have implicated that Mediterranean diets (MDs) partially protect against breast c...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/13/7/2431 |
_version_ | 1797526424764022784 |
---|---|
author | Fabiola N. Velazquez Valentina Viscardi Julia Montemage Leiqing Zhang Carolena Trocchia Megan M. Delamont Rasheed Ahmad Yusuf A. Hannun Lina M. Obeid Ashley J. Snider |
author_facet | Fabiola N. Velazquez Valentina Viscardi Julia Montemage Leiqing Zhang Carolena Trocchia Megan M. Delamont Rasheed Ahmad Yusuf A. Hannun Lina M. Obeid Ashley J. Snider |
author_sort | Fabiola N. Velazquez |
collection | DOAJ |
description | A high-fat diet (HFD) and obesity are risk factors for many diseases including breast cancer. This is particularly important with close to 40% of the current adult population being overweight or obese. Previous studies have implicated that Mediterranean diets (MDs) partially protect against breast cancer. However, to date, the links between diet and breast cancer progression are not well defined. Therefore, to begin to define and assess this, we used an isocaloric control diet (CD) and two HFDs enriched with either olive oil (OOBD, high in oleate, and unsaturated fatty acid in MDs) or a milk fat-based diet (MFBD, high in palmitate and myristate, saturated fatty acids in Western diets) in a mammary polyomavirus middle T antigen mouse model (MMTV-PyMT) of breast cancer. Our data demonstrate that neither MFBD or OOBD altered the growth of primary tumors in the MMTV-PyMT mice. The examination of lung metastases revealed that OOBD mice exhibited fewer surface nodules and smaller metastases when compared to MFBD and CD mice. These data suggest that different fatty acids found in different sources of HFDs may alter breast cancer metastasis. |
first_indexed | 2024-03-10T09:30:03Z |
format | Article |
id | doaj.art-f61e1750c363434cbc596c4d3884c44c |
institution | Directory Open Access Journal |
issn | 2072-6643 |
language | English |
last_indexed | 2024-03-10T09:30:03Z |
publishDate | 2021-07-01 |
publisher | MDPI AG |
record_format | Article |
series | Nutrients |
spelling | doaj.art-f61e1750c363434cbc596c4d3884c44c2023-11-22T04:37:21ZengMDPI AGNutrients2072-66432021-07-01137243110.3390/nu13072431A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast CancerFabiola N. Velazquez0Valentina Viscardi1Julia Montemage2Leiqing Zhang3Carolena Trocchia4Megan M. Delamont5Rasheed Ahmad6Yusuf A. Hannun7Lina M. Obeid8Ashley J. Snider9Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USADepartment of Medicine, Stony Brook University, Stony Brook, NY 11794, USADepartment of Medicine, Stony Brook University, Stony Brook, NY 11794, USADepartment of Medicine, Stony Brook University, Stony Brook, NY 11794, USADepartment of Medicine, Stony Brook University, Stony Brook, NY 11794, USADepartment of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USAImmunology & Microbiology Department, Dasman Diabetes Institute, Kuwait City 15462, KuwaitDepartment of Medicine, Stony Brook University, Stony Brook, NY 11794, USADepartment of Medicine, Stony Brook University, Stony Brook, NY 11794, USADepartment of Medicine, Stony Brook University, Stony Brook, NY 11794, USAA high-fat diet (HFD) and obesity are risk factors for many diseases including breast cancer. This is particularly important with close to 40% of the current adult population being overweight or obese. Previous studies have implicated that Mediterranean diets (MDs) partially protect against breast cancer. However, to date, the links between diet and breast cancer progression are not well defined. Therefore, to begin to define and assess this, we used an isocaloric control diet (CD) and two HFDs enriched with either olive oil (OOBD, high in oleate, and unsaturated fatty acid in MDs) or a milk fat-based diet (MFBD, high in palmitate and myristate, saturated fatty acids in Western diets) in a mammary polyomavirus middle T antigen mouse model (MMTV-PyMT) of breast cancer. Our data demonstrate that neither MFBD or OOBD altered the growth of primary tumors in the MMTV-PyMT mice. The examination of lung metastases revealed that OOBD mice exhibited fewer surface nodules and smaller metastases when compared to MFBD and CD mice. These data suggest that different fatty acids found in different sources of HFDs may alter breast cancer metastasis.https://www.mdpi.com/2072-6643/13/7/2431dietfatty acidbreast cancerlung metastasis |
spellingShingle | Fabiola N. Velazquez Valentina Viscardi Julia Montemage Leiqing Zhang Carolena Trocchia Megan M. Delamont Rasheed Ahmad Yusuf A. Hannun Lina M. Obeid Ashley J. Snider A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer Nutrients diet fatty acid breast cancer lung metastasis |
title | A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer |
title_full | A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer |
title_fullStr | A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer |
title_full_unstemmed | A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer |
title_short | A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer |
title_sort | milk fat based diet increases metastasis in the mmtv pymt mouse model of breast cancer |
topic | diet fatty acid breast cancer lung metastasis |
url | https://www.mdpi.com/2072-6643/13/7/2431 |
work_keys_str_mv | AT fabiolanvelazquez amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT valentinaviscardi amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT juliamontemage amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT leiqingzhang amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT carolenatrocchia amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT meganmdelamont amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT rasheedahmad amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT yusufahannun amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT linamobeid amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT ashleyjsnider amilkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT fabiolanvelazquez milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT valentinaviscardi milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT juliamontemage milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT leiqingzhang milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT carolenatrocchia milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT meganmdelamont milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT rasheedahmad milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT yusufahannun milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT linamobeid milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer AT ashleyjsnider milkfatbaseddietincreasesmetastasisinthemmtvpymtmousemodelofbreastcancer |