Possible functional scaffolds for periodontal regeneration
Periodontal diseases are the most prevalent infectious diseases with the irreversible loss of tooth supporting apparatus. To reestablish the stable health of periodontal tissues after healing, the concept of regenerative surgical procedures has been developed over the past three decades, including v...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-11-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761613000446 |
| _version_ | 1811237971259555840 |
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| author | Hidetoshi Shimauchi Eiji Nemoto Hiroshi Ishihata Masatsugu Shimomura |
| author_facet | Hidetoshi Shimauchi Eiji Nemoto Hiroshi Ishihata Masatsugu Shimomura |
| author_sort | Hidetoshi Shimauchi |
| collection | DOAJ |
| description | Periodontal diseases are the most prevalent infectious diseases with the irreversible loss of tooth supporting apparatus. To reestablish the stable health of periodontal tissues after healing, the concept of regenerative surgical procedures has been developed over the past three decades, including various grafting materials, guided tissue regeneration (GTR), and the use of enamel matrix derivatives (EMD) in a clinical setting. More recently, tissue engineering strategies have also been applied and developed for periodontal regeneration: (1) stem cell therapies; (2) recombinant human growth factor therapies; (3) combined use of cell and growth factors with matrix-based scaffolds. However, the complete and predictable reconstruction of healthy periodontal tissues still remains a challenging field. To overcome therapeutic limitations and develop stem cell-based strategies, it is necessary to optimize cell–scaffold combinations by understanding the cellular events during periodontal wound healing and regeneration. We reviewed: (1) the current status and strategies for periodontal regeneration; (2) a possible biomaterial design for the scaffold used in periodontal tissue engineering; (3) a possible interaction between scaffold materials and periodontal tissue cells. |
| first_indexed | 2024-04-12T12:33:38Z |
| format | Article |
| id | doaj.art-f620aadfa9ca45e6b9786cd851b765b7 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-04-12T12:33:38Z |
| publishDate | 2013-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-f620aadfa9ca45e6b9786cd851b765b72022-12-22T03:32:58ZengElsevierJapanese Dental Science Review1882-76162013-11-0149411813010.1016/j.jdsr.2013.05.001Possible functional scaffolds for periodontal regenerationHidetoshi Shimauchi0Eiji Nemoto1Hiroshi Ishihata2Masatsugu Shimomura3Division of Periodontology and Endodontology, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JapanDivision of Periodontology and Endodontology, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JapanDivision of Periodontology and Endodontology, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JapanOrganized Polymer Material, Institute of Multidisciplinary Research for Advanced Materials Laboratory (IMRAM), Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, JapanPeriodontal diseases are the most prevalent infectious diseases with the irreversible loss of tooth supporting apparatus. To reestablish the stable health of periodontal tissues after healing, the concept of regenerative surgical procedures has been developed over the past three decades, including various grafting materials, guided tissue regeneration (GTR), and the use of enamel matrix derivatives (EMD) in a clinical setting. More recently, tissue engineering strategies have also been applied and developed for periodontal regeneration: (1) stem cell therapies; (2) recombinant human growth factor therapies; (3) combined use of cell and growth factors with matrix-based scaffolds. However, the complete and predictable reconstruction of healthy periodontal tissues still remains a challenging field. To overcome therapeutic limitations and develop stem cell-based strategies, it is necessary to optimize cell–scaffold combinations by understanding the cellular events during periodontal wound healing and regeneration. We reviewed: (1) the current status and strategies for periodontal regeneration; (2) a possible biomaterial design for the scaffold used in periodontal tissue engineering; (3) a possible interaction between scaffold materials and periodontal tissue cells.http://www.sciencedirect.com/science/article/pii/S1882761613000446Periodontal regenerationScaffoldTissue engineeringCell–scaffold interaction |
| spellingShingle | Hidetoshi Shimauchi Eiji Nemoto Hiroshi Ishihata Masatsugu Shimomura Possible functional scaffolds for periodontal regeneration Japanese Dental Science Review Periodontal regeneration Scaffold Tissue engineering Cell–scaffold interaction |
| title | Possible functional scaffolds for periodontal regeneration |
| title_full | Possible functional scaffolds for periodontal regeneration |
| title_fullStr | Possible functional scaffolds for periodontal regeneration |
| title_full_unstemmed | Possible functional scaffolds for periodontal regeneration |
| title_short | Possible functional scaffolds for periodontal regeneration |
| title_sort | possible functional scaffolds for periodontal regeneration |
| topic | Periodontal regeneration Scaffold Tissue engineering Cell–scaffold interaction |
| url | http://www.sciencedirect.com/science/article/pii/S1882761613000446 |
| work_keys_str_mv | AT hidetoshishimauchi possiblefunctionalscaffoldsforperiodontalregeneration AT eijinemoto possiblefunctionalscaffoldsforperiodontalregeneration AT hiroshiishihata possiblefunctionalscaffoldsforperiodontalregeneration AT masatsugushimomura possiblefunctionalscaffoldsforperiodontalregeneration |