Reproductive risk factors associated with breast cancer in young women by molecular subtype
Background: Few studies have examined detailed features of pregnancy and the postpartum period as potential risk factors for early onset breast cancer (BC) by molecular subtype. These data may have value for improving risk assessment and prevention. Methods: We surveyed parous enrollees in the prosp...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977622001874 |
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| author | Kathryn J. Ruddy Robert A. Vierkant Nusrat Jahan Alexandra Higgins Ann Partridge Nicole Larson Derek C. Radisky Fergus Couch Janet Olson Mark E. Sherman |
| author_facet | Kathryn J. Ruddy Robert A. Vierkant Nusrat Jahan Alexandra Higgins Ann Partridge Nicole Larson Derek C. Radisky Fergus Couch Janet Olson Mark E. Sherman |
| author_sort | Kathryn J. Ruddy |
| collection | DOAJ |
| description | Background: Few studies have examined detailed features of pregnancy and the postpartum period as potential risk factors for early onset breast cancer (BC) by molecular subtype. These data may have value for improving risk assessment and prevention. Methods: We surveyed parous enrollees in the prospective Mayo Clinic Breast Disease Registry (MCBDR) who had been diagnosed with BC at age <55 years between 2015 and 2020. Summary statistics were used to describe survey responses and reproductive risk factors by BC subtype (defined by estrogen/progesterone receptors and human epidermal growth factor receptor expression, nurse-abstracted from the medical record). Associations were assessed with Kruskal-Wallis and Chi-Square tests, followed by age-adjusted linear and logistic regression models. We compared results from this parous cohort to those from a separate cohort of nulliparous MCBDR participants with BC diagnosed at age <55 years. Results: In 436 parous respondents with subtype data abstracted, we identified a higher frequency of BRCA1 mutation, earlier age at diagnosis, and lower BI in patients with triple negative BC. Comparing parous to nulliparous young women with breast cancer, the proportion with TNBC was larger in the latter (12.2% vs. 15.1%, p = 0.03). Conclusions: Early age at diagnosis and deleterious BRCA1 mutation were more frequent among TNBC patients. In addition, parous young women with TNBC had a lower BI than those with other BC subtypes, a hypothesis-generating finding that supports the need for additional research on the cycle of pregnancy-lactation-postpartum involution and BC etiology. |
| first_indexed | 2024-04-12T00:49:53Z |
| format | Article |
| id | doaj.art-f621dcb84ec84cd3bda0e1b3f420eb74 |
| institution | Directory Open Access Journal |
| issn | 1532-3080 |
| language | English |
| last_indexed | 2024-04-12T00:49:53Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj.art-f621dcb84ec84cd3bda0e1b3f420eb742022-12-22T03:54:46ZengElsevierBreast1532-30802022-12-0166272277Reproductive risk factors associated with breast cancer in young women by molecular subtypeKathryn J. Ruddy0Robert A. Vierkant1Nusrat Jahan2Alexandra Higgins3Ann Partridge4Nicole Larson5Derek C. Radisky6Fergus Couch7Janet Olson8Mark E. Sherman9Department of Oncology, Mayo Clinic, Rochester, MN, USA; Corresponding author. 200 First St. SW, Rochester, MN, 55905, USA.Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USADepartment of Oncology, Mayo Clinic, Rochester, MN, USADepartment of Oncology, Mayo Clinic, Rochester, MN, USADivision of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USADepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USADepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USADepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USADepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USABackground: Few studies have examined detailed features of pregnancy and the postpartum period as potential risk factors for early onset breast cancer (BC) by molecular subtype. These data may have value for improving risk assessment and prevention. Methods: We surveyed parous enrollees in the prospective Mayo Clinic Breast Disease Registry (MCBDR) who had been diagnosed with BC at age <55 years between 2015 and 2020. Summary statistics were used to describe survey responses and reproductive risk factors by BC subtype (defined by estrogen/progesterone receptors and human epidermal growth factor receptor expression, nurse-abstracted from the medical record). Associations were assessed with Kruskal-Wallis and Chi-Square tests, followed by age-adjusted linear and logistic regression models. We compared results from this parous cohort to those from a separate cohort of nulliparous MCBDR participants with BC diagnosed at age <55 years. Results: In 436 parous respondents with subtype data abstracted, we identified a higher frequency of BRCA1 mutation, earlier age at diagnosis, and lower BI in patients with triple negative BC. Comparing parous to nulliparous young women with breast cancer, the proportion with TNBC was larger in the latter (12.2% vs. 15.1%, p = 0.03). Conclusions: Early age at diagnosis and deleterious BRCA1 mutation were more frequent among TNBC patients. In addition, parous young women with TNBC had a lower BI than those with other BC subtypes, a hypothesis-generating finding that supports the need for additional research on the cycle of pregnancy-lactation-postpartum involution and BC etiology.http://www.sciencedirect.com/science/article/pii/S0960977622001874Breast neoplasmsPregnancyLactationPremenopausal |
| spellingShingle | Kathryn J. Ruddy Robert A. Vierkant Nusrat Jahan Alexandra Higgins Ann Partridge Nicole Larson Derek C. Radisky Fergus Couch Janet Olson Mark E. Sherman Reproductive risk factors associated with breast cancer in young women by molecular subtype Breast Breast neoplasms Pregnancy Lactation Premenopausal |
| title | Reproductive risk factors associated with breast cancer in young women by molecular subtype |
| title_full | Reproductive risk factors associated with breast cancer in young women by molecular subtype |
| title_fullStr | Reproductive risk factors associated with breast cancer in young women by molecular subtype |
| title_full_unstemmed | Reproductive risk factors associated with breast cancer in young women by molecular subtype |
| title_short | Reproductive risk factors associated with breast cancer in young women by molecular subtype |
| title_sort | reproductive risk factors associated with breast cancer in young women by molecular subtype |
| topic | Breast neoplasms Pregnancy Lactation Premenopausal |
| url | http://www.sciencedirect.com/science/article/pii/S0960977622001874 |
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