Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial
Background: Despite the crucial role of educators in encourage students' academic learning, addressing educator stress inside the classroom remains a significant challenge in the educational context. Mindfulness Meditation training (MM) has been recommended as an environmental enrichment strate...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354621001757 |
| _version_ | 1819174598602653696 |
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| author | Daniela Rodrigues de Oliveira David Wilson Fanny Palace-Berl Bárbara de Mello Ponteciano Luciana Fungaro Rissatti Flávia Sardela de Miranda Valéria Piassa Pollizi José Carlos Fuscella Alex Mourão Terzi Ana Paula Lepique Vânia D'Almeida Marcelo Demarzo |
| author_facet | Daniela Rodrigues de Oliveira David Wilson Fanny Palace-Berl Bárbara de Mello Ponteciano Luciana Fungaro Rissatti Flávia Sardela de Miranda Valéria Piassa Pollizi José Carlos Fuscella Alex Mourão Terzi Ana Paula Lepique Vânia D'Almeida Marcelo Demarzo |
| author_sort | Daniela Rodrigues de Oliveira |
| collection | DOAJ |
| description | Background: Despite the crucial role of educators in encourage students' academic learning, addressing educator stress inside the classroom remains a significant challenge in the educational context. Mindfulness Meditation training (MM) has been recommended as an environmental enrichment strategy in schools to help teachers cope with stress and cultivating a state of awareness in daily life. Although studies have shown that MM can improve immune system dynamics the biological mechanism underlying glutathione metabolism in a healthy human is unclear Objective: The purpose of this study was to determine whether MM training benefits psychological and behavioral response, immunological functions and glutathione metabolism in service healthy female teachers from public schools Methods: We randomly assigned 76 teachers to an 8-week Mindfulness-Based Health Program for Educators (MBHPEduca) or Neuroscience for Education program (Neuro-Educa; active control group). Using the quality of life as our primary outcome, perceived stress, negative affectivity, and resilience as our secondary outcome, and pro-inflammatory cytokines and glutathione levels as our third outcome at baseline and post-intervention that occurred in public schools. Blood samples were collected for the measurement of three proinflammatory markers, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-8 (IL-8) and three GSH metabolism, including Cysteine (Cys), Homocysteine (HCys) and GSH were conducted at pre-and post-intervention, with selfreported assessments over time. Treatment effects were analyzed using generalized estimating equations (GEE) with to intention to treat Results: We observed statistically significant improvements to the MBHP-Educa group compared to active control in perceived stress, resilience, positive and negative affect, and quality of life after 8-weeks MM (p < 0.0001). Further, the MBHP-Educa group exhibited lower circulating IL-6 production accompanied by high circulating GSH, and Cys (p < 0.0001). Additional analyses indicated that enhancing quality of life through mindfulness meditation training was mediated by reducing perceived stress and serum levels of IL- 6 and increasing resilience and teachers ‘plasma GSH levels Conclusions: The present study is a pilot trial with low-power and provides preliminary evidence that mindfulness meditation training help teachers to cope with stress in the school environment with an impact on the quality of life, immune function, and glutathione metabolism. |
| first_indexed | 2024-12-22T20:41:31Z |
| format | Article |
| id | doaj.art-f621f531c70b4b0d84ba8a15cab6eaeb |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-12-22T20:41:31Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-f621f531c70b4b0d84ba8a15cab6eaeb2022-12-21T18:13:19ZengElsevierBrain, Behavior, & Immunity - Health2666-35462021-12-0118100372Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trialDaniela Rodrigues de Oliveira0David Wilson1Fanny Palace-Berl2Bárbara de Mello Ponteciano3Luciana Fungaro Rissatti4Flávia Sardela de Miranda5Valéria Piassa Pollizi6José Carlos Fuscella7Alex Mourão Terzi8Ana Paula Lepique9Vânia D'Almeida10Marcelo Demarzo11Mente Aberta - Brazilian Center for Mindfulness and Health Promotion, Departamento de Medicina Preventiva, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Departamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Corresponding author. Departamento de Patologia, Universidade Federal de São Paulo, Departamento de Medicina Preventiva, Universidade Federal de São Paulo, Laboratório de Investigação Médica (LIM-26), Departamento de Cirurgia, Universidade de São Paulo, São Paulo, SP, Brazil.Mente Aberta - Brazilian Center for Mindfulness and Health Promotion, Departamento de Medicina Preventiva, Universidade Federal de São Paulo, São Paulo, SP, BrazilDepartamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, BrazilDepartamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Laboratório de Investigação Médica (LIM-26), Departamento de Cirurgia, Universidade de São Paulo, SP, BrazilDepartamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, BrazilLaboratório de Imunomodulação, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, BrazilMente Aberta - Brazilian Center for Mindfulness and Health Promotion, Departamento de Medicina Preventiva, Universidade Federal de São Paulo, São Paulo, SP, BrazilCentro Educacional Objetivo, São Paulo, SP, BrazilInstituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais, Campus, São João del-Rei, MG, BrazilLaboratório de Imunomodulação, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, BrazilDepartamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, BrazilMente Aberta - Brazilian Center for Mindfulness and Health Promotion, Departamento de Medicina Preventiva, Universidade Federal de São Paulo, São Paulo, SP, BrazilBackground: Despite the crucial role of educators in encourage students' academic learning, addressing educator stress inside the classroom remains a significant challenge in the educational context. Mindfulness Meditation training (MM) has been recommended as an environmental enrichment strategy in schools to help teachers cope with stress and cultivating a state of awareness in daily life. Although studies have shown that MM can improve immune system dynamics the biological mechanism underlying glutathione metabolism in a healthy human is unclear Objective: The purpose of this study was to determine whether MM training benefits psychological and behavioral response, immunological functions and glutathione metabolism in service healthy female teachers from public schools Methods: We randomly assigned 76 teachers to an 8-week Mindfulness-Based Health Program for Educators (MBHPEduca) or Neuroscience for Education program (Neuro-Educa; active control group). Using the quality of life as our primary outcome, perceived stress, negative affectivity, and resilience as our secondary outcome, and pro-inflammatory cytokines and glutathione levels as our third outcome at baseline and post-intervention that occurred in public schools. Blood samples were collected for the measurement of three proinflammatory markers, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-8 (IL-8) and three GSH metabolism, including Cysteine (Cys), Homocysteine (HCys) and GSH were conducted at pre-and post-intervention, with selfreported assessments over time. Treatment effects were analyzed using generalized estimating equations (GEE) with to intention to treat Results: We observed statistically significant improvements to the MBHP-Educa group compared to active control in perceived stress, resilience, positive and negative affect, and quality of life after 8-weeks MM (p < 0.0001). Further, the MBHP-Educa group exhibited lower circulating IL-6 production accompanied by high circulating GSH, and Cys (p < 0.0001). Additional analyses indicated that enhancing quality of life through mindfulness meditation training was mediated by reducing perceived stress and serum levels of IL- 6 and increasing resilience and teachers ‘plasma GSH levels Conclusions: The present study is a pilot trial with low-power and provides preliminary evidence that mindfulness meditation training help teachers to cope with stress in the school environment with an impact on the quality of life, immune function, and glutathione metabolism.http://www.sciencedirect.com/science/article/pii/S2666354621001757Mindfulness meditationTeachersGlutathione metabolismInflammatory cytokinesStressQuality of life |
| spellingShingle | Daniela Rodrigues de Oliveira David Wilson Fanny Palace-Berl Bárbara de Mello Ponteciano Luciana Fungaro Rissatti Flávia Sardela de Miranda Valéria Piassa Pollizi José Carlos Fuscella Alex Mourão Terzi Ana Paula Lepique Vânia D'Almeida Marcelo Demarzo Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial Brain, Behavior, & Immunity - Health Mindfulness meditation Teachers Glutathione metabolism Inflammatory cytokines Stress Quality of life |
| title | Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial |
| title_full | Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial |
| title_fullStr | Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial |
| title_full_unstemmed | Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial |
| title_short | Mindfulness meditation training effects on quality of life, immune function and glutathione metabolism in service healthy female teachers: A randomized pilot clinical trial |
| title_sort | mindfulness meditation training effects on quality of life immune function and glutathione metabolism in service healthy female teachers a randomized pilot clinical trial |
| topic | Mindfulness meditation Teachers Glutathione metabolism Inflammatory cytokines Stress Quality of life |
| url | http://www.sciencedirect.com/science/article/pii/S2666354621001757 |
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