Evaluation of Toxicological Risks of Nail Coatings Containing Acrylate Monomer HEMA
Individuals working in nail salons are exposed to 2-hydroxyethyl methacrylate (HEMA). HEMA has been found to have several effects on the skin: skin itching, peeling, redness and allergic contact dermatitis. The purpose of the study was to compare the effects of nail coatings containing HEMA and 2-hy...
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| Format: | Article |
| Language: | English |
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Kaunas University of Technology
2022-09-01
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| Series: | Medžiagotyra |
| Subjects: | |
| Online Access: | https://matsc.ktu.lt/index.php/MatSc/article/view/30803 |
| _version_ | 1798002330190217216 |
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| author | Zane GRIGALE-SOROCINA Ingmars BIRKS Anna RAMATA-STUNDA Estefanija BOGDANOVA |
| author_facet | Zane GRIGALE-SOROCINA Ingmars BIRKS Anna RAMATA-STUNDA Estefanija BOGDANOVA |
| author_sort | Zane GRIGALE-SOROCINA |
| collection | DOAJ |
| description | Individuals working in nail salons are exposed to 2-hydroxyethyl methacrylate (HEMA). HEMA has been found to have several effects on the skin: skin itching, peeling, redness and allergic contact dermatitis. The purpose of the study was to compare the effects of nail coatings containing HEMA and 2-hydroxypropyl methacrylate (HPMA) on the skin. In this study we explored the irritation properties of HEMA and HPMA containing nail coatings in cell cultures in-vitro and in skin PATCH tests under dermatological control. The cytotoxicity of coatings was tested in BALB/c3T3 and HaCaT cell lines by a neutral red uptake assay. Cytotoxicity was expressed as a concentration-dependent reduction of the uptake of neutral red, compared to the untreated controls. Open patch tests were supervised by a certified dermatologist. Polymerized coating extracts have little effect on Balb/c 3T3 cell viability, while having mild cytotoxic effects on HaCaT keratinocytes. Among two tested samples, extracts of HEMA containing coating exhibited higher cytotoxicity – reduction of keratinocyte viability by 28.29 % in case of undiluted 24 h extract and even by 48.26 % in case of 50 % extract was observed. Coating cytotoxiaty observed on HaCaT showed that the keratinocyte cell line was more sensitive to HEMA than to HPMA containing coating. |
| first_indexed | 2024-04-11T11:50:25Z |
| format | Article |
| id | doaj.art-f6227dbda652416486c3b4a244fbc4f8 |
| institution | Directory Open Access Journal |
| issn | 1392-1320 2029-7289 |
| language | English |
| last_indexed | 2024-04-11T11:50:25Z |
| publishDate | 2022-09-01 |
| publisher | Kaunas University of Technology |
| record_format | Article |
| series | Medžiagotyra |
| spelling | doaj.art-f6227dbda652416486c3b4a244fbc4f82022-12-22T04:25:24ZengKaunas University of TechnologyMedžiagotyra1392-13202029-72892022-09-0110.5755/j02.ms.3080336057Evaluation of Toxicological Risks of Nail Coatings Containing Acrylate Monomer HEMAZane GRIGALE-SOROCINA0https://orcid.org/0000-0003-3092-7811Ingmars BIRKS1Anna RAMATA-STUNDA2Estefanija BOGDANOVA3Riga Technical UniversityR&D, Kinetics Nail SystemsUniversity of LatviaR&D, Kinetics Nail SystemsIndividuals working in nail salons are exposed to 2-hydroxyethyl methacrylate (HEMA). HEMA has been found to have several effects on the skin: skin itching, peeling, redness and allergic contact dermatitis. The purpose of the study was to compare the effects of nail coatings containing HEMA and 2-hydroxypropyl methacrylate (HPMA) on the skin. In this study we explored the irritation properties of HEMA and HPMA containing nail coatings in cell cultures in-vitro and in skin PATCH tests under dermatological control. The cytotoxicity of coatings was tested in BALB/c3T3 and HaCaT cell lines by a neutral red uptake assay. Cytotoxicity was expressed as a concentration-dependent reduction of the uptake of neutral red, compared to the untreated controls. Open patch tests were supervised by a certified dermatologist. Polymerized coating extracts have little effect on Balb/c 3T3 cell viability, while having mild cytotoxic effects on HaCaT keratinocytes. Among two tested samples, extracts of HEMA containing coating exhibited higher cytotoxicity – reduction of keratinocyte viability by 28.29 % in case of undiluted 24 h extract and even by 48.26 % in case of 50 % extract was observed. Coating cytotoxiaty observed on HaCaT showed that the keratinocyte cell line was more sensitive to HEMA than to HPMA containing coating.https://matsc.ktu.lt/index.php/MatSc/article/view/30803coatingsacrylate monomerscytotoxicitynail coatingshydroxyethyl methacrylate |
| spellingShingle | Zane GRIGALE-SOROCINA Ingmars BIRKS Anna RAMATA-STUNDA Estefanija BOGDANOVA Evaluation of Toxicological Risks of Nail Coatings Containing Acrylate Monomer HEMA Medžiagotyra coatings acrylate monomers cytotoxicity nail coatings hydroxyethyl methacrylate |
| title | Evaluation of Toxicological Risks of Nail Coatings Containing Acrylate Monomer HEMA |
| title_full | Evaluation of Toxicological Risks of Nail Coatings Containing Acrylate Monomer HEMA |
| title_fullStr | Evaluation of Toxicological Risks of Nail Coatings Containing Acrylate Monomer HEMA |
| title_full_unstemmed | Evaluation of Toxicological Risks of Nail Coatings Containing Acrylate Monomer HEMA |
| title_short | Evaluation of Toxicological Risks of Nail Coatings Containing Acrylate Monomer HEMA |
| title_sort | evaluation of toxicological risks of nail coatings containing acrylate monomer hema |
| topic | coatings acrylate monomers cytotoxicity nail coatings hydroxyethyl methacrylate |
| url | https://matsc.ktu.lt/index.php/MatSc/article/view/30803 |
| work_keys_str_mv | AT zanegrigalesorocina evaluationoftoxicologicalrisksofnailcoatingscontainingacrylatemonomerhema AT ingmarsbirks evaluationoftoxicologicalrisksofnailcoatingscontainingacrylatemonomerhema AT annaramatastunda evaluationoftoxicologicalrisksofnailcoatingscontainingacrylatemonomerhema AT estefanijabogdanova evaluationoftoxicologicalrisksofnailcoatingscontainingacrylatemonomerhema |