Improvement of solubility and pharmacokinetic profile of hepatoprotector icariin through complexation with HP-γ-cyclodextrin

Improvement of solubility and pharmacokinetic profile of hepatoprotector icariin through complexation with HP-γ-cyclodextrin

Icariin as a hepatoprotector from Herba epimedii can expand the cardiovascular and cerebral blood vessels, promote hematopoietic functions, enhance the immune system and show anti-liver tumor activities. However, its low solubility (0.02 mg/mL) limits its clinical applications as food and medical su...

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Bibliographic Details
Main Authors: Yili Ding, Bo Yu, Shuzhen Zhou, Charles Ding, Zhiyuan Zhang, Shufeng Xu, Zhe Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
icariin
inclusion complex
water solubility
in vitro and in vivo PK study
cyclodextrin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1138686/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1138686/full

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