Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors
<i>Background:</i> Lymphocyte telomere length is strongly correlated with patient prognosis in several malignant tumor types and is thought to be related to tumor immunity. However, this correlation has not been studied in gynecological cancers. We determined the prognostic significance...
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MDPI AG
2020-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1469 |
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| author | Kamrunnahar Shanta Kentaro Nakayama Masako Ishikawa Tomoka Ishibashi Hitomi Yamashita Seiya Sato Hiroki Sasamori Kiyoka Sawada Sonomi Kurose Hossain Mohammad Mahmud Sultana Razia Kouji Iida Noriyoshi Ishikawa Satoru Kyo |
| author_facet | Kamrunnahar Shanta Kentaro Nakayama Masako Ishikawa Tomoka Ishibashi Hitomi Yamashita Seiya Sato Hiroki Sasamori Kiyoka Sawada Sonomi Kurose Hossain Mohammad Mahmud Sultana Razia Kouji Iida Noriyoshi Ishikawa Satoru Kyo |
| author_sort | Kamrunnahar Shanta |
| collection | DOAJ |
| description | <i>Background:</i> Lymphocyte telomere length is strongly correlated with patient prognosis in several malignant tumor types and is thought to be related to tumor immunity. However, this correlation has not been studied in gynecological cancers. We determined the prognostic significance of peripheral blood lymphocyte telomere length in gynecologic cancers. <i>Methods:</i> Telomere length of lymphocytes from patients with gynecological malignant tumors (ovarian cancer (OC), <i>N</i> = 72; cervical cancer (CC), <i>N</i> = 63; endometrial cancer (EC), <i>N</i> = 87) was examined by quantitative reverse-transcription PCR of isolated mononuclear cells. Kaplan–Meier and Cox proportional hazard analyses were used to determine the association between lymphocyte telomere length and clinicopathological factors. <i>Results:</i> The overall survival (OS) and progression-free survival (PFS) of patients were based on the dichotomized lymphocyte telomere length using the median as a threshold (OC: 0.75, CC: 1.94, and EC: 1.09). A short telomere length was significantly correlated with residual tumors (≥1 cm) in OC and with advanced stage (III and IV) of CC. In OC and CC, patients with shorter relative lymphocyte telomere length (RLT) had significantly poorer OS and PFS than patients with longer RLT (<i>p</i> = 0.002, <i>p</i> = 0.003, and <i>p</i> = 0.001, <i>p</i> = 0.001, respectively). However, in EC, RLT was not significantly associated with OS or PFS (<i>p</i> = 0.567 and <i>p</i> = 0.304, log-rank test). Multivariate analysis showed that shorter RLT was a significant independent prognostic factor of PFS and OS for OC (<i>p</i> = 0.03 and <i>p</i> = 0.04, respectively) and CC (<i>p</i> = 0.02 and <i>p</i> = 0.03, respectively). <i>Conclusions:</i> Patients with OC and CC with shorter lymphocyte telomeres have significantly reduced survival; therefore, the peripheral blood lymphocyte telomere length is a prognostic biomarker in OC and CC. |
| first_indexed | 2024-03-10T19:22:20Z |
| format | Article |
| id | doaj.art-f62299b2e9264958b3f140773defb80d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:22:20Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
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| series | Cancers |
| spelling | doaj.art-f62299b2e9264958b3f140773defb80d2023-11-20T02:53:35ZengMDPI AGCancers2072-66942020-06-01126146910.3390/cancers12061469Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant TumorsKamrunnahar Shanta0Kentaro Nakayama1Masako Ishikawa2Tomoka Ishibashi3Hitomi Yamashita4Seiya Sato5Hiroki Sasamori6Kiyoka Sawada7Sonomi Kurose8Hossain Mohammad Mahmud9Sultana Razia10Kouji Iida11Noriyoshi Ishikawa12Satoru Kyo13Department of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, JapanDepartment of Organ Pathology, Shimane University Faculty of Medicine, Izumo 693-8501, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan<i>Background:</i> Lymphocyte telomere length is strongly correlated with patient prognosis in several malignant tumor types and is thought to be related to tumor immunity. However, this correlation has not been studied in gynecological cancers. We determined the prognostic significance of peripheral blood lymphocyte telomere length in gynecologic cancers. <i>Methods:</i> Telomere length of lymphocytes from patients with gynecological malignant tumors (ovarian cancer (OC), <i>N</i> = 72; cervical cancer (CC), <i>N</i> = 63; endometrial cancer (EC), <i>N</i> = 87) was examined by quantitative reverse-transcription PCR of isolated mononuclear cells. Kaplan–Meier and Cox proportional hazard analyses were used to determine the association between lymphocyte telomere length and clinicopathological factors. <i>Results:</i> The overall survival (OS) and progression-free survival (PFS) of patients were based on the dichotomized lymphocyte telomere length using the median as a threshold (OC: 0.75, CC: 1.94, and EC: 1.09). A short telomere length was significantly correlated with residual tumors (≥1 cm) in OC and with advanced stage (III and IV) of CC. In OC and CC, patients with shorter relative lymphocyte telomere length (RLT) had significantly poorer OS and PFS than patients with longer RLT (<i>p</i> = 0.002, <i>p</i> = 0.003, and <i>p</i> = 0.001, <i>p</i> = 0.001, respectively). However, in EC, RLT was not significantly associated with OS or PFS (<i>p</i> = 0.567 and <i>p</i> = 0.304, log-rank test). Multivariate analysis showed that shorter RLT was a significant independent prognostic factor of PFS and OS for OC (<i>p</i> = 0.03 and <i>p</i> = 0.04, respectively) and CC (<i>p</i> = 0.02 and <i>p</i> = 0.03, respectively). <i>Conclusions:</i> Patients with OC and CC with shorter lymphocyte telomeres have significantly reduced survival; therefore, the peripheral blood lymphocyte telomere length is a prognostic biomarker in OC and CC.https://www.mdpi.com/2072-6694/12/6/1469relative lymphocyte telomere lengthovarian cancercervical cancerendometrial canceroverall survivalprogression-free survival |
| spellingShingle | Kamrunnahar Shanta Kentaro Nakayama Masako Ishikawa Tomoka Ishibashi Hitomi Yamashita Seiya Sato Hiroki Sasamori Kiyoka Sawada Sonomi Kurose Hossain Mohammad Mahmud Sultana Razia Kouji Iida Noriyoshi Ishikawa Satoru Kyo Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors Cancers relative lymphocyte telomere length ovarian cancer cervical cancer endometrial cancer overall survival progression-free survival |
| title | Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors |
| title_full | Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors |
| title_fullStr | Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors |
| title_full_unstemmed | Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors |
| title_short | Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors |
| title_sort | prognostic value of peripheral blood lymphocyte telomere length in gynecologic malignant tumors |
| topic | relative lymphocyte telomere length ovarian cancer cervical cancer endometrial cancer overall survival progression-free survival |
| url | https://www.mdpi.com/2072-6694/12/6/1469 |
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