Metal-Based Nanomaterials for the Sensing of NSAIDS
Cadmium sulfide and zinc oxide nanoparticles were prepared, characterized and used as electrode modifiers for the sensing of two non-steroidal anti-inflammatory drugs (NSAIDs): naproxen and mobic. The structural and morphological characterization of the synthesized nanoparticles was carried out by X...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/14/7/630 |
| _version_ | 1797212200178286592 |
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| author | Farah Quddus Afzal Shah Naimat Ullah Iltaf Shah |
| author_facet | Farah Quddus Afzal Shah Naimat Ullah Iltaf Shah |
| author_sort | Farah Quddus |
| collection | DOAJ |
| description | Cadmium sulfide and zinc oxide nanoparticles were prepared, characterized and used as electrode modifiers for the sensing of two non-steroidal anti-inflammatory drugs (NSAIDs): naproxen and mobic. The structural and morphological characterization of the synthesized nanoparticles was carried out by XRD, UV-Vis spectroscopy, FTIR and scanning electron microscopy. The electrode’s enhanced surface area facilitated the signal amplification of the selected NSAIDs. The CdS-modified glassy carbon electrode (GCE) enhanced the electro-oxidation signals of naproxen to four times that of the bare GCE, while the ZnO-modified GCE led to a two-fold enhancement in the electro-oxidation signals of mobic. The oxidation of both NSAIDs occurred in a pH-dependent manner, suggesting the involvement of protons in their electron transfer reactions. The experimental conditions for the sensing of naproxen and mobic were optimized and, under optimized conditions, the modified electrode surface demonstrated the qualities of sensitivity and selectivity, and a fast responsiveness to the target NSAIDs. |
| first_indexed | 2024-04-24T10:38:36Z |
| format | Article |
| id | doaj.art-f623757a0e2248e78fc5b555b1e70ec3 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-24T10:38:36Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-f623757a0e2248e78fc5b555b1e70ec32024-04-12T13:24:02ZengMDPI AGNanomaterials2079-49912024-04-0114763010.3390/nano14070630Metal-Based Nanomaterials for the Sensing of NSAIDSFarah Quddus0Afzal Shah1Naimat Ullah2Iltaf Shah3Department of Chemistry, Quaid-I-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesCadmium sulfide and zinc oxide nanoparticles were prepared, characterized and used as electrode modifiers for the sensing of two non-steroidal anti-inflammatory drugs (NSAIDs): naproxen and mobic. The structural and morphological characterization of the synthesized nanoparticles was carried out by XRD, UV-Vis spectroscopy, FTIR and scanning electron microscopy. The electrode’s enhanced surface area facilitated the signal amplification of the selected NSAIDs. The CdS-modified glassy carbon electrode (GCE) enhanced the electro-oxidation signals of naproxen to four times that of the bare GCE, while the ZnO-modified GCE led to a two-fold enhancement in the electro-oxidation signals of mobic. The oxidation of both NSAIDs occurred in a pH-dependent manner, suggesting the involvement of protons in their electron transfer reactions. The experimental conditions for the sensing of naproxen and mobic were optimized and, under optimized conditions, the modified electrode surface demonstrated the qualities of sensitivity and selectivity, and a fast responsiveness to the target NSAIDs.https://www.mdpi.com/2079-4991/14/7/630cadmium sulfidezinc oxideNSAIDsnaproxenmobic |
| spellingShingle | Farah Quddus Afzal Shah Naimat Ullah Iltaf Shah Metal-Based Nanomaterials for the Sensing of NSAIDS Nanomaterials cadmium sulfide zinc oxide NSAIDs naproxen mobic |
| title | Metal-Based Nanomaterials for the Sensing of NSAIDS |
| title_full | Metal-Based Nanomaterials for the Sensing of NSAIDS |
| title_fullStr | Metal-Based Nanomaterials for the Sensing of NSAIDS |
| title_full_unstemmed | Metal-Based Nanomaterials for the Sensing of NSAIDS |
| title_short | Metal-Based Nanomaterials for the Sensing of NSAIDS |
| title_sort | metal based nanomaterials for the sensing of nsaids |
| topic | cadmium sulfide zinc oxide NSAIDs naproxen mobic |
| url | https://www.mdpi.com/2079-4991/14/7/630 |
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