Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model
Mutations that enhance the activity of protein kinase C alpha (PKCα) are associated with Alzheimer’s Disease. Here, the authors report that the enhanced activity of one variant, PKCα M489V, is sufficient to rewire the brain phosphoproteome, drive synaptic degeneration, and impair cognition in a mous...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34679-7 |
| _version_ | 1811211938893398016 |
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| author | Gema Lordén Jacob M. Wozniak Kim Doré Lara E. Dozier Chelsea Cates-Gatto Gentry N. Patrick David J. Gonzalez Amanda J. Roberts Rudolph E. Tanzi Alexandra C. Newton |
| author_facet | Gema Lordén Jacob M. Wozniak Kim Doré Lara E. Dozier Chelsea Cates-Gatto Gentry N. Patrick David J. Gonzalez Amanda J. Roberts Rudolph E. Tanzi Alexandra C. Newton |
| author_sort | Gema Lordén |
| collection | DOAJ |
| description | Mutations that enhance the activity of protein kinase C alpha (PKCα) are associated with Alzheimer’s Disease. Here, the authors report that the enhanced activity of one variant, PKCα M489V, is sufficient to rewire the brain phosphoproteome, drive synaptic degeneration, and impair cognition in a mouse model. |
| first_indexed | 2024-04-12T05:20:48Z |
| format | Article |
| id | doaj.art-f626c5ecba534cfcaa1608a36cecb5d0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T05:20:48Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f626c5ecba534cfcaa1608a36cecb5d02022-12-22T03:46:28ZengNature PortfolioNature Communications2041-17232022-11-0113111610.1038/s41467-022-34679-7Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse modelGema Lordén0Jacob M. Wozniak1Kim Doré2Lara E. Dozier3Chelsea Cates-Gatto4Gentry N. Patrick5David J. Gonzalez6Amanda J. Roberts7Rudolph E. Tanzi8Alexandra C. Newton9Department of Pharmacology, University of California San DiegoDepartment of Pharmacology, University of California San DiegoCenter for Neural Circuits and Behavior, Department of Neurosciences, University of California San DiegoSection of Neurobiology. Division of Biological sciences, University of California San DiegoAnimal Models Core Facility, The Scripps Research InstituteSection of Neurobiology. Division of Biological sciences, University of California San DiegoDepartment of Pharmacology, University of California San DiegoAnimal Models Core Facility, The Scripps Research InstituteGenetics and Aging Research Unit, McCance Center for Brain Health, Department of Neurology, Department of Neurology, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Pharmacology, University of California San DiegoMutations that enhance the activity of protein kinase C alpha (PKCα) are associated with Alzheimer’s Disease. Here, the authors report that the enhanced activity of one variant, PKCα M489V, is sufficient to rewire the brain phosphoproteome, drive synaptic degeneration, and impair cognition in a mouse model.https://doi.org/10.1038/s41467-022-34679-7 |
| spellingShingle | Gema Lordén Jacob M. Wozniak Kim Doré Lara E. Dozier Chelsea Cates-Gatto Gentry N. Patrick David J. Gonzalez Amanda J. Roberts Rudolph E. Tanzi Alexandra C. Newton Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model Nature Communications |
| title | Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model |
| title_full | Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model |
| title_fullStr | Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model |
| title_full_unstemmed | Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model |
| title_short | Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model |
| title_sort | enhanced activity of alzheimer disease associated variant of protein kinase cα drives cognitive decline in a mouse model |
| url | https://doi.org/10.1038/s41467-022-34679-7 |
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