HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV)
Introduction. Surface immunoglobulin expression is a main immunophenotypic criteria of mature subtype of B-lineage acute lymphoblastic leukemia. Although the majority of such cases represents Burkitt leukemia/lymphoma, it was shown for several times that membrane IgM could be detected in the absence...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2018-02-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/265 |
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| author | I. A. Demina Т. Yu. Verzhbitskaya S. A. Kashpor L. V. Baidun T. V. Koniuhova S. A. Plyasunova G. А. Tsaur E. B. Rusanova M. V. Gorchakova E. E. Zueva A. N. Kazakova E. A. Zerkalenkova Yu. V. Olshanskaya Yu. G. Abugova L. G. Fechina N. V. Miakova E. V. Samochatova А. А. Maschan А. M. Popov |
| author_facet | I. A. Demina Т. Yu. Verzhbitskaya S. A. Kashpor L. V. Baidun T. V. Koniuhova S. A. Plyasunova G. А. Tsaur E. B. Rusanova M. V. Gorchakova E. E. Zueva A. N. Kazakova E. A. Zerkalenkova Yu. V. Olshanskaya Yu. G. Abugova L. G. Fechina N. V. Miakova E. V. Samochatova А. А. Maschan А. M. Popov |
| author_sort | I. A. Demina |
| collection | DOAJ |
| description | Introduction. Surface immunoglobulin expression is a main immunophenotypic criteria of mature subtype of B-lineage acute lymphoblastic leukemia. Although the majority of such cases represents Burkitt leukemia/lymphoma, it was shown for several times that membrane IgM could be detected in the absence of other mature lymphomas signs.The aim of the study was to evaluate heterogeneity of childhood acute lymphoblastic leukemia (ALL) with surface IgM expression and to assess correspondence of BIV EGIL ALL subtype with Burkitt lymphoma (BL) bone marrow dissemination.Materials and methods. Immunophenotypic, cytomorfologic and genetic data of 54 BIV-ALL cases were analyzed.Results. Among the studied patients 39 had BL, while others belonged to B-cell precursor ALL (BCP-ALL). All BL patients and none of BCP-ALL patients carried C-MYC rearrangement while in BCP-ALL group in 8 cases and in any BL cases KMT2A rearrangements were found. None of BCP-ALL children had L3 morphology according to FAB classification.Conclusions. B-lineage ALL with surface IgM expression is rather heterogeneous group of cases including typical BL and rare cases of BCP-ALL even with KMT2A-rearrangements. Combination of all available diagnostic technologies will allow precise split of these two different disease and select the appropriate treatment scheme. |
| first_indexed | 2024-04-09T20:26:05Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:26:05Z |
| publishDate | 2018-02-01 |
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| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-f627e049edb64d5ea4bf26c1dff209da2023-03-30T20:15:11ZrusABV-pressОнкогематология1818-83462413-40232018-02-01124344010.17650/1818-8346-2017-12-4-34-40252HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV)I. A. Demina0Т. Yu. Verzhbitskaya1S. A. Kashpor2L. V. Baidun3T. V. Koniuhova4S. A. Plyasunova5G. А. Tsaur6E. B. Rusanova7M. V. Gorchakova8E. E. Zueva9A. N. Kazakova10E. A. Zerkalenkova11Yu. V. Olshanskaya12Yu. G. Abugova13L. G. Fechina14N. V. Miakova15E. V. Samochatova16А. А. Maschan17А. M. Popov18Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologySverdlovsk Regional Clinical Children’s Hospital No 1; Research Institute of Medical Cell TechnologiesDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyRussian Children Clinical Hospital, Ministry of Health of RussiaDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologySverdlovsk Regional Clinical Children’s Hospital No 1; Research Institute of Medical Cell TechnologiesI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia; Ariel UniversityDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologySverdlovsk Regional Clinical Children’s Hospital No 1; Research Institute of Medical Cell TechnologiesDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyIntroduction. Surface immunoglobulin expression is a main immunophenotypic criteria of mature subtype of B-lineage acute lymphoblastic leukemia. Although the majority of such cases represents Burkitt leukemia/lymphoma, it was shown for several times that membrane IgM could be detected in the absence of other mature lymphomas signs.The aim of the study was to evaluate heterogeneity of childhood acute lymphoblastic leukemia (ALL) with surface IgM expression and to assess correspondence of BIV EGIL ALL subtype with Burkitt lymphoma (BL) bone marrow dissemination.Materials and methods. Immunophenotypic, cytomorfologic and genetic data of 54 BIV-ALL cases were analyzed.Results. Among the studied patients 39 had BL, while others belonged to B-cell precursor ALL (BCP-ALL). All BL patients and none of BCP-ALL patients carried C-MYC rearrangement while in BCP-ALL group in 8 cases and in any BL cases KMT2A rearrangements were found. None of BCP-ALL children had L3 morphology according to FAB classification.Conclusions. B-lineage ALL with surface IgM expression is rather heterogeneous group of cases including typical BL and rare cases of BCP-ALL even with KMT2A-rearrangements. Combination of all available diagnostic technologies will allow precise split of these two different disease and select the appropriate treatment scheme.https://oncohematology.abvpress.ru/ongm/article/view/265burkitt lymphoma/leukemiaacute lymphoblastic leukemiaflow cytometry |
| spellingShingle | I. A. Demina Т. Yu. Verzhbitskaya S. A. Kashpor L. V. Baidun T. V. Koniuhova S. A. Plyasunova G. А. Tsaur E. B. Rusanova M. V. Gorchakova E. E. Zueva A. N. Kazakova E. A. Zerkalenkova Yu. V. Olshanskaya Yu. G. Abugova L. G. Fechina N. V. Miakova E. V. Samochatova А. А. Maschan А. M. Popov HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV) Онкогематология burkitt lymphoma/leukemia acute lymphoblastic leukemia flow cytometry |
| title | HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV) |
| title_full | HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV) |
| title_fullStr | HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV) |
| title_full_unstemmed | HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV) |
| title_short | HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV) |
| title_sort | heterogeneity of childhood b cell acute lymphoblastic leukemia egil subtype biv |
| topic | burkitt lymphoma/leukemia acute lymphoblastic leukemia flow cytometry |
| url | https://oncohematology.abvpress.ru/ongm/article/view/265 |
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