Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis
Background: Chest computed tomography (CT) is the gold standard for the evaluation of systemic sclerosis-related interstitial lung disease (SSc-ILD). Lung ultrasound (LUS) is a radiation-free tool that identifies the B-lines as a main feature of ILD. We aimed to investigate the role of LUS in the ev...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/7/1696 |
| _version_ | 1797406811922366464 |
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| author | Cosimo Bruni Lavinia Mattolini Lorenzo Tofani Luna Gargani Nicholas Landini Nicola Roma Gemma Lepri Martina Orlandi Serena Guiducci Silvia Bellando-Randone Chiara Romei Yukai Wang Marco Matucci-Cerinic |
| author_facet | Cosimo Bruni Lavinia Mattolini Lorenzo Tofani Luna Gargani Nicholas Landini Nicola Roma Gemma Lepri Martina Orlandi Serena Guiducci Silvia Bellando-Randone Chiara Romei Yukai Wang Marco Matucci-Cerinic |
| author_sort | Cosimo Bruni |
| collection | DOAJ |
| description | Background: Chest computed tomography (CT) is the gold standard for the evaluation of systemic sclerosis-related interstitial lung disease (SSc-ILD). Lung ultrasound (LUS) is a radiation-free tool that identifies the B-lines as a main feature of ILD. We aimed to investigate the role of LUS in the evaluation of the extent of SSc-ILD. Methods: Adult SSc patients underwent pulmonary function tests (PFTs), LUS and CT. The CT images were qualitatively, semi-quantitatively (the Wells score on five levels and the categorical Goh et al. staging) and quantitatively (histogram-based densitometry) analysed for ILD. LUS quantified B-lines in 21 intercostal spaces on both the anterior and posterior chest wall. Results: Out of the 77 SSc patients eligible for the study, 35 presented with ILD on CT (21 limited, 14 extensive). Total B-lines significantly differentiated ILD vs. no ILD (median 24 vs. 8, <i>p</i> < 0.001). Posterior and total B-lines significantly differentiated limited from absent ILD, while anterior B-lines distinguished extensive from limited ILD. Total B-lines correlated with the Wells score (r = 0.446, <i>p</i> < 0.001) and MLA (r = −0.571, <i>p</i> < 0.001); similar results were confirmed when anterior and posterior B-lines were analysed separately. Conclusions: LUS is a useful tool to identify SSc-ILD and to correlate with different evaluations of ILD extent and severity. |
| first_indexed | 2024-03-09T03:32:00Z |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T03:32:00Z |
| publishDate | 2022-07-01 |
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| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f628ba6a74344bffacf5a9806b4596bb2023-12-03T14:55:04ZengMDPI AGDiagnostics2075-44182022-07-01127169610.3390/diagnostics12071696Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic SclerosisCosimo Bruni0Lavinia Mattolini1Lorenzo Tofani2Luna Gargani3Nicholas Landini4Nicola Roma5Gemma Lepri6Martina Orlandi7Serena Guiducci8Silvia Bellando-Randone9Chiara Romei10Yukai Wang11Marco Matucci-Cerinic12Department Experimental and Clinical Medicine, Division of Rheumatology, Careggi University Hospital, University of Florence, 50141 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2, Careggi University Hospital, University of Florence, 50141 Florence, ItalyDepartment Experimental and Clinical Medicine, Division of Rheumatology, Careggi University Hospital, University of Florence, 50141 Florence, ItalyDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2, Careggi University Hospital, University of Florence, 50141 Florence, ItalyDepartment of Radiology, Ca’ Foncello General Hospital, 31100 Treviso, ItalyDepartment Experimental and Clinical Medicine, Division of Rheumatology, Careggi University Hospital, University of Florence, 50141 Florence, ItalyDepartment Experimental and Clinical Medicine, Division of Rheumatology, Careggi University Hospital, University of Florence, 50141 Florence, ItalyDepartment Experimental and Clinical Medicine, Division of Rheumatology, Careggi University Hospital, University of Florence, 50141 Florence, ItalyDepartment Experimental and Clinical Medicine, Division of Rheumatology, Careggi University Hospital, University of Florence, 50141 Florence, ItalyDepartment of Radiology, Pisa University Hospital, 56124 Pisa, ItalyRheumatology and Immunology Department, Shantou Central Hospital, Shantou 515031, ChinaDepartment Experimental and Clinical Medicine, Division of Rheumatology, Careggi University Hospital, University of Florence, 50141 Florence, ItalyBackground: Chest computed tomography (CT) is the gold standard for the evaluation of systemic sclerosis-related interstitial lung disease (SSc-ILD). Lung ultrasound (LUS) is a radiation-free tool that identifies the B-lines as a main feature of ILD. We aimed to investigate the role of LUS in the evaluation of the extent of SSc-ILD. Methods: Adult SSc patients underwent pulmonary function tests (PFTs), LUS and CT. The CT images were qualitatively, semi-quantitatively (the Wells score on five levels and the categorical Goh et al. staging) and quantitatively (histogram-based densitometry) analysed for ILD. LUS quantified B-lines in 21 intercostal spaces on both the anterior and posterior chest wall. Results: Out of the 77 SSc patients eligible for the study, 35 presented with ILD on CT (21 limited, 14 extensive). Total B-lines significantly differentiated ILD vs. no ILD (median 24 vs. 8, <i>p</i> < 0.001). Posterior and total B-lines significantly differentiated limited from absent ILD, while anterior B-lines distinguished extensive from limited ILD. Total B-lines correlated with the Wells score (r = 0.446, <i>p</i> < 0.001) and MLA (r = −0.571, <i>p</i> < 0.001); similar results were confirmed when anterior and posterior B-lines were analysed separately. Conclusions: LUS is a useful tool to identify SSc-ILD and to correlate with different evaluations of ILD extent and severity.https://www.mdpi.com/2075-4418/12/7/1696systemic sclerosisinterstitial lung diseasecomputed tomographyultrasoundradiomics |
| spellingShingle | Cosimo Bruni Lavinia Mattolini Lorenzo Tofani Luna Gargani Nicholas Landini Nicola Roma Gemma Lepri Martina Orlandi Serena Guiducci Silvia Bellando-Randone Chiara Romei Yukai Wang Marco Matucci-Cerinic Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis Diagnostics systemic sclerosis interstitial lung disease computed tomography ultrasound radiomics |
| title | Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis |
| title_full | Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis |
| title_fullStr | Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis |
| title_full_unstemmed | Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis |
| title_short | Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis |
| title_sort | lung ultrasound b lines in the evaluation of the extent of interstitial lung disease in systemic sclerosis |
| topic | systemic sclerosis interstitial lung disease computed tomography ultrasound radiomics |
| url | https://www.mdpi.com/2075-4418/12/7/1696 |
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