Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive debilitating neurodegenerative disease and the most common form of dementia in the older population. At present, there is no definitive effective treatment for AD. Therefore, researchers are now looking at stem cell therapy as a possible treatment for AD, bu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/18/10151 |
| _version_ | 1797518863893528576 |
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| author | Hau Jun Chan Yanshree Jaydeep Roy George Lim Tipoe Man-Lung Fung Lee Wei Lim |
| author_facet | Hau Jun Chan Yanshree Jaydeep Roy George Lim Tipoe Man-Lung Fung Lee Wei Lim |
| author_sort | Hau Jun Chan |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive debilitating neurodegenerative disease and the most common form of dementia in the older population. At present, there is no definitive effective treatment for AD. Therefore, researchers are now looking at stem cell therapy as a possible treatment for AD, but whether stem cells are safe and effective in humans is still not clear. In this narrative review, we discuss both preclinical studies and clinical trials on the therapeutic potential of human stem cells in AD. Preclinical studies have successfully differentiated stem cells into neurons in vitro, indicating the potential viability of stem cell therapy in neurodegenerative diseases. Preclinical studies have also shown that stem cell therapy is safe and effective in improving cognitive performance in animal models, as demonstrated in the Morris water maze test and novel object recognition test. Although few clinical trials have been completed and many trials are still in phase I and II, the initial results confirm the outcomes of the preclinical studies. However, limitations like rejection, tumorigenicity, and ethical issues are still barriers to the advancement of stem cell therapy. In conclusion, the use of stem cells in the treatment of AD shows promise in terms of effectiveness and safety. |
| first_indexed | 2024-03-10T07:35:21Z |
| format | Article |
| id | doaj.art-f6291780e52649a9bf80dd5c06e62381 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:35:21Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f6291780e52649a9bf80dd5c06e623812023-11-22T13:33:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122181015110.3390/ijms221810151Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s DiseaseHau Jun Chan0Yanshree1Jaydeep Roy2George Lim Tipoe3Man-Lung Fung4Lee Wei Lim5School of Biomedical, Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical, Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical, Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical, Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical, Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Biomedical, Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaAlzheimer’s disease (AD) is a progressive debilitating neurodegenerative disease and the most common form of dementia in the older population. At present, there is no definitive effective treatment for AD. Therefore, researchers are now looking at stem cell therapy as a possible treatment for AD, but whether stem cells are safe and effective in humans is still not clear. In this narrative review, we discuss both preclinical studies and clinical trials on the therapeutic potential of human stem cells in AD. Preclinical studies have successfully differentiated stem cells into neurons in vitro, indicating the potential viability of stem cell therapy in neurodegenerative diseases. Preclinical studies have also shown that stem cell therapy is safe and effective in improving cognitive performance in animal models, as demonstrated in the Morris water maze test and novel object recognition test. Although few clinical trials have been completed and many trials are still in phase I and II, the initial results confirm the outcomes of the preclinical studies. However, limitations like rejection, tumorigenicity, and ethical issues are still barriers to the advancement of stem cell therapy. In conclusion, the use of stem cells in the treatment of AD shows promise in terms of effectiveness and safety.https://www.mdpi.com/1422-0067/22/18/10151stem cellsneurogenesisAlzheimer’s diseasestem cell therapyneural stem cellsneurodegenerative disease |
| spellingShingle | Hau Jun Chan Yanshree Jaydeep Roy George Lim Tipoe Man-Lung Fung Lee Wei Lim Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease International Journal of Molecular Sciences stem cells neurogenesis Alzheimer’s disease stem cell therapy neural stem cells neurodegenerative disease |
| title | Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease |
| title_full | Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease |
| title_fullStr | Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease |
| title_full_unstemmed | Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease |
| title_short | Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease |
| title_sort | therapeutic potential of human stem cell implantation in alzheimer s disease |
| topic | stem cells neurogenesis Alzheimer’s disease stem cell therapy neural stem cells neurodegenerative disease |
| url | https://www.mdpi.com/1422-0067/22/18/10151 |
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